Methyl 2 Bromopyridine 4 Carboxylate
pyridine pyrrole pyrazine piperidine piperazine

Methyl 2-Bromopyridine-4-Carboxylate

    Specifications

    HS Code

    197096

    Chemical Formula C7H6BrNO2
    Molar Mass 216.03 g/mol
    Appearance Solid (usually white or off - white)
    Solubility In Water Low solubility
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Melting Point Typically in the range of 80 - 85°C
    Purity Can be available in high purity grades (e.g., 95%+)
    Stability Stable under normal conditions, but sensitive to strong bases and reducing agents

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    General Information
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    Frequently Asked Questions

    As a leading Methyl 2-Bromopyridine-4-Carboxylate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of Methyl 2-Bromopyridine-4-Carboxylate?
    Methyl-2-bromopyridine-4-carboxylic acid ester, this is an organic compound. It has unique chemical properties and is related to many chemical properties and reactions.
    In terms of its physical properties, it is mostly solid or liquid at room temperature, depending on specific conditions. In terms of solubility, it is usually insoluble in water, but soluble in common organic solvents such as ethanol, ether, chloroform, etc. This property makes it well dispersed and reactive in organic synthesis reaction systems.
    From the perspective of chemical properties, the functional groups contained in the molecule dominate its reactivity. Bromine atoms are highly active and can initiate nucleophilic substitution reactions. Under appropriate conditions, nucleophiles can attack the carbon atoms attached to bromine atoms, causing bromine ions to leave and form new compounds. For example, in an alkaline environment with alcohols, nucleophilic substitution can occur, and bromine is replaced by alkoxy groups to obtain corresponding ester derivatives.
    The carboxymethyl ester moiety also has significant chemical activity. It can participate in hydrolysis reactions. Under acidic or alkaline conditions, ester bonds are broken to form 2-bromopyridine-4-carboxylic acids and methanol. In alkaline hydrolysis, the reaction is more complete because the resulting carboxylate is more stable. In addition, carboxymethyl esters can also react with ammonia or amines to form amide derivatives, which are often used in organic synthesis to construct nitrogen-containing compounds.
    The pyridine ring endows the compound with unique electronic properties and aromaticity. The nitrogen atom of the pyridine ring has a lone pair of electrons, which can be used as an electron donor to participate in the coordination reaction and form complexes with metal ions, which has potential applications in the field of catalysis. At the same time, the aromaticity of the pyridine ring makes the molecule relatively stable and can withstand chemical reactions under certain conditions without serious damage to the pyridine ring structure.
    These chemical properties of methyl-2-bromopyridine-4-carboxylic acid esters make them play an important role in organic synthesis, medicinal chemistry and other fields, providing key starting materials and intermediates for the preparation of various functional compounds.
    What are the common synthesis methods of Methyl 2-Bromopyridine-4-Carboxylate?
    The common synthesis methods of fugmethyl-2-bromopyridine-4-carboxylic acid esters generally have the following numbers.
    One is to use 2-pyridinecarboxylic acid as the starting material, first esterification reaction with methanol under the action of concentrated sulfuric acid and other catalysts to obtain methyl pyridine-4-carboxylate. During the reaction, it is necessary to control the temperature and time to make the two fully react. Then, in a suitable solvent, such as dichloromethane, under appropriate conditions, bromination is carried out with a brominating agent such as N-bromosuccinimide (NBS), and bromine atoms are introduced at the 2-position of the pyridine ring to obtain methyl-2-bromopyridine-4-carboxylate. During this process, factors such as the amount of brominating agent, reaction temperature and time have a significant impact on the yield and purity of the product.
    The second is to use 2-bromopyridine as the starting material, and first introduce the carboxyl group at its 4-position through a suitable method. For example, through the reaction of Grignard's reagent, magnesium and 2-bromopyridine are prepared into Grignard's reagent, and then the carboxyl group is introduced by the reaction with carbon dioxide, and then the esterification reaction with methanol can also obtain the target product. In this path, the preparation of Grignard's reagent requires an anhydrous and oxygen-free environment, and the conditions of each step of the reaction need to be precisely controlled in order to obtain ideal results.
    There are other compounds containing pyridine structures as starting materials, and the structure of the target molecule is gradually constructed through multi-step transformation, such as modification and substitution of functional groups. However, such methods are more complicated and require high reaction conditions and operation skills.
    All synthesis methods need to consider the availability of raw materials, the difficulty of reaction conditions, the separation and purification of products, and many other factors. Only by selecting the best one can the methyl-2-bromopyridine-4-carboxylic acid ester be efficiently prepared.
    Where is Methyl 2-Bromopyridine-4-Carboxylate used?
    Methyl-2-bromopyridine-4-carboxylic acid ester, which is used in various fields. In the field of medicinal chemistry, it is often a key raw material for the creation of drugs. Due to the structural properties of pyridine and carboxylic acid esters, it can participate in a variety of chemical reactions to construct molecular structures with specific biological activities. For example, through nucleophilic substitution reactions, bromine atoms can be replaced with different functional groups, thereby modifying the activity and properties of compounds, which is very helpful for the development of antibacterial and anti-inflammatory drugs.
    In the field of materials science, it can also be seen. It may be used to prepare organic materials with special properties. The pyridine ring imparts certain electronic properties and stability to the material, while the carboxylic acid ester group can participate in the polymerization reaction to form a polymer material. The resulting material may have unique optical and electrical properties, and may have potential applications in the field of optoelectronic materials such as organic Light Emitting Diodes (OLEDs) and solar cells.
    In the field of organic synthesis chemistry, methyl-2-bromopyridine-4-carboxylate is an extremely important synthesis intermediate. Chemists can use it to conduct multi-step reactions by ingeniously designing reaction routes to synthesize complex and novel organic compounds. Due to the differences in reactivity at different check points in the structure, it provides rich possibilities for the design of synthesis strategies, which greatly promotes the development of organic synthetic chemistry and helps to create more organic molecules with unique structures and functions.
    What is the market price of Methyl 2-Bromopyridine-4-Carboxylate?
    I don't know the price of "Methyl 2 - Bromopyridine - 4 - Carboxylate". This is a fine chemical, and its price often changes due to multiple reasons.
    First, the quality is related to the price. If the purity is very high and the impurities are rare, it is suitable for high-end scientific research or pharmaceutical fields with strict quality requirements, and the price will be high. On the contrary, if the purity is slightly lower, it is only used for general industrial use, and the price may be slightly lower.
    Second, the supply and demand trend has a great impact. If the market demand for it is strong and the supply is limited, if the demand for products containing this ingredient in a certain industry increases sharply during a specific period, and the manufacturer fails to expand production capacity in time, the price will rise. If there is an oversupply, the manufacturer may reduce the price in order to promote sales.
    Third, the difficulty of production also affects the price. If the synthesis of this compound requires complex processes, expensive raw materials and harsh reaction conditions, the cost will also be high. If the process is relatively simple, the cost is controllable, and the price may be more accessible to the people.
    Fourth, factors such as the manufacturer's brand and after-sales also play a role. Well-known large factories are famous for their quality and reputation, and the product price may be higher than that of ordinary manufacturers. And if the manufacturer can provide high-quality after-sales, such as technical support, return and exchange services, etc., it will also be reflected in the price.
    Due to the above factors changing from time to time, it is difficult to determine the exact market price of "Methyl 2 - Bromopyridine - 4 - Carboxylate". To know the price, you need to consult chemical product suppliers, check chemical market information platforms, or learn about the market at relevant industry exhibitions to obtain more accurate price information.
    What are the storage conditions for Methyl 2-Bromopyridine-4-Carboxylate?
    Methyl-2-bromopyridine-4-carboxylic acid ester is also an organic chemical substance. Its storage conditions are crucial, which is related to the stability and quality of this substance.
    This substance should be stored in a cool and dry place. If it is cool, it should be protected from heat. It is easy to accelerate chemical reactions due to heat, or to cause decomposition and deterioration. Under high temperature, the molecular activity is enhanced, and chemical bonds are easily broken, which will damage the structure and properties of this substance.
    A dry environment is also indispensable. Water vapor in the air may react with methyl-2-bromopyridine-4-carboxylic acid ester, or hydrolyze, or affect its purity. If moisture enters, it will interact with the active parts in it, causing the composition to change and reducing its effect.
    Furthermore, it needs to be placed in a well-ventilated place. If the ventilation is smooth, the accumulation of harmful gases can be avoided. If this substance volatilizes harmful vapor, it can be dispersed by ventilation, keeping the storage environment safe, and preventing the vapor from mixing with air into an explosive mixture.
    At the same time, it should be kept away from fire sources and oxidants. Methyl-2-bromopyridine-4-carboxylate has a certain chemical activity, which is flammable in case of fire, and is prone to violent reactions when encountering oxidants, and there is a danger of explosion. Therefore, when storing, it must be separated from fire sources and oxidants to ensure the safety of the storage process.
    In addition, storage containers should also be selected carefully. When using corrosion-resistant and well-sealed containers. Corrosion resistance can prevent the container from reacting with the object and damaging the substance; if the seal is good, it can block the intrusion of air and water vapor, and ensure the stability of the substance. All these are essential for the storage of methyl-2-bromopyridine-4-carboxylate.