methyl 1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Methyl-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid ester has a wide range of uses. In the field of medicinal chemistry, it is a key intermediate for the preparation of a variety of drugs. For example, many biologically active heterocyclic compounds are often synthesized by relying on them as starting materials. Through specific chemical reactions and delicate steps, drug molecules with unique pharmacological properties can be obtained, making outstanding contributions to the treatment and prevention of diseases.
In the field of materials science, or can participate in the creation of functional materials. Due to its special molecular structure, or the unique properties that can endow materials with specific properties, such as optics, electricity, etc., the resulting materials find a place in the fields of optoelectronic devices, sensors, etc., and contribute to the development of related technologies.
In the field of organic synthetic chemistry, as an important building block, it can react with a variety of reagents to build complex organic molecular structures. Chemists can skillfully design synthetic routes according to their reaction characteristics, prepare organic compounds with novel structures and unique functions, promote the progress of organic synthetic chemistry, and expand the variety and application of compounds.

The physical properties of methyl 1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid esters are as follows.
Looking at its morphology, it is often in a solid state. Due to the intermolecular forces, it has a relatively regular arrangement. As for the color, it is mostly white or almost white, just like the purity of the first snow, without the disturbance of variegation. This is the characterization of its relatively regular and pure structure.
When it comes to solubility, it is quite soluble in organic solvents such as ethanol and acetone. Due to the fact that appropriate intermolecular forces, such as hydrogen bonds and van der Waals forces, can be formed between the molecules of caustic ethanol and acetone and the compound, they are soluble. However, in water, its solubility is not good. Due to the large proportion of hydrophobic parts in its molecular structure, it is difficult to form an effective interaction with water molecules. The polarity of water and the polarity of the compound are quite different, making it difficult for the two to dissolve.
Its melting point is also one of the important physical properties. After experimental determination, a specific melting point value can be obtained, which reflects the strength of the intermolecular force. The melting point is established, which can be used as an important basis for identifying the substance and is also a key parameter for its state transition under specific conditions.
In addition, density is also a consideration factor. Density reflects the mass per unit volume of a substance and is related to the degree of accumulation of molecules. Knowing its density is of great significance in practical applications, such as material ratio, separation and purification. All these physical properties are related to each other, and together they describe the physical properties of methyl 1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate.

Methyl-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid ester, this is an organic compound. It has many unique chemical properties, which are described in detail today.
From the structural point of view, the compound contains a pyridine ring, and the pyridine ring is at the 6-position aerobic group, and the 1-position and 3-position are connected with methyl and carboxylic acid methyl ester groups, respectively. This specific structure makes it stable, but due to the substituents on the ring, it also has unique reactivity. < Br >
When it comes to acidity and alkalinity, its atypical acid or base, the basicity is weakened due to the influence of the lone pair electron of the pyridine cyclic nitrogen atom by the adjacent substituents. And there is no obvious acidic hydrogen atom in the molecule, so the overall acidity and alkalinity are not significant.
In terms of solubility, considering that the molecule contains hydrophobic groups such as ester groups and methyl groups, the solubility in polar solvents such as water is poor, and it has good solubility in organic solvents such as chloroform and dichloromethane, this property is of great significance for the extraction and separation steps of organic synthesis.
In terms of reactivity, the ester group can undergo hydrolysis reaction. Under acidic or alkaline conditions, the ester bond is broken, and the corresponding carboxylic acid and alcohol The nitrogen atom of the pyridine ring can participate in nucleophilic substitution reactions, such as reacting with halogenated hydrocarbons to form quaternary ammonium salts. At the same time, under the influence of the 6-position oxygen group, the electron cloud density of the pyridine ring changes, making the specific position on the ring prone to electrophilic substitution reactions.
And because it contains multiple unsaturated bonds, it can participate in addition reactions, such as hydrogenation with hydrogen under the action of a suitable catalyst, and the pyridine ring is partially or fully hydrogenated. These many chemical properties make it widely used in organic synthesis and pharmaceutical chemistry, and can be used as a key intermediate in the synthesis of complex compounds.

There are currently compounds of methyl 1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid esters. The synthesis method is as follows.
First, a suitable starting material is taken, usually a compound containing a pyridine ring structure. Pyridine derivatives with suitable substituents can be selected, and they can be reacted in multiple steps to form the target product.
The first step may require modification of a specific position of the pyridine ring. Under appropriate reaction conditions, such as in the presence of suitable solvents and catalysts, a nucleophilic substitution reaction is used to introduce methyl groups into the 1-position of the pyridine ring. This reaction requires precise control of the reaction temperature, time and ratio of reactants to make the reaction proceed smoothly and with high selectivity.
Then, the 6-position of the pyridine ring is oxidized to construct the 6-oxo structure. This oxidation step requires the selection of suitable oxidizing agents, such as specific metal oxides or organic peroxides, to ensure that only the 6-position is oxidized without affecting the substituents at other positions.
Furthermore, the carboxylic acid ester group is introduced at the 3-position of the pyridine ring. It can be reacted with reagents containing carboxylic acid ester functional groups, such as esterification or similar nucleophilic addition-elimination reactions. This process also requires careful selection of reaction conditions so that the carboxylic acid ester group is accurately connected to the 3-position.
After each step of the reaction is completed, it needs to be separated and purified to obtain pure methyl 1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate. Commonly used purification methods include column chromatography, recrystallization, etc. to remove impurities generated in the reaction and obtain a high-purity target product. In this way, this compound can be synthesized.

The price range of methyl-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate in the market is difficult to determine. The price of this substance often changes for various reasons. First, the price of raw materials fluctuates. If the production of this compound requires specific raw materials, if the production of raw materials changes, or the supply and demand are unbalanced, the price will vary. Second, the difference in craftsmanship also affects. Sophisticated craftsmanship can reduce costs, but complicated methods may cause costs to rise, and the price will follow. Furthermore, the supply and demand relationship of the market is the main reason. If there are many applicants and the supply is limited, the price will rise; if the supply exceeds the demand, the price will fall. In addition, the origin, purity and other factors are also related to its price. In different land systems, due to differences in manpower, taxes, etc., the price varies. Those with high purity have high regular prices. Therefore, in order to know the exact price, you must consider the situation in detail and consult the chemical raw material supplier or relevant market analysis institutions to obtain a near-real price.