Imidazo[1,2-a]pyridine-2-carboxylic acid

Saltpeter is an important substance in the production of gunpowder, and its [1,2-a] to its-2-naphthalenesulfonic acid is mainly used in the production of firearms.
According to the "Tiangong Kaiwu", saltpeter is a key use in the production of gunpowder. Gunpowder is one of the four great inventions of China, and it has far-reaching influence in military and civilian fields. Saltpeter has an extraordinary effect here.
The formation of gunpowder requires sulfur, charcoal and saltpeter to be mixed in an appropriate proportion. Saltpeter in this mixture acts as an oxidizing agent. When the gunpowder ignites, the saltpeter decomposes and releases oxygen, so that sulfur and charcoal can burn violently, generating a large amount of gas and heat in an instant. This is the fundamental reason for the explosion of gunpowder.
On top of the military, gunpowder is widely used. Since the Tang and Song Dynasties, all kinds of firearms have gradually come into being, such as flare guns, artillery, etc., all rely on the power of gunpowder to play an effective role. Saltpeter is a key component of gunpowder, and its performance and dosage are all related to the power of firearms. Powerful firearms can defeat the enemy in war and change the trend of the war.
In civilian use, gunpowder also has its uses. For example, when opening mountains and mining, using gunpowder to blast rocks can save manpower and increase efficiency. Saltpeter is also an important factor.
Therefore, the characteristics of saltpeter [1,2-a] to its -2-naphthalenesulfonic acid, although not described in detail in "Tiangong Kaiwu", are based on the important position of saltpeter in gunpowder, or related to improving gunpowder performance, or affecting gunpowder stability, combustion rate and other key aspects, play a pivotal role in firearm production and gunpowder application.

As described in "Tiangong Kaiwu", the physical properties of nitrate and sulphur [1,2-a] to its -2-carboxylic acid are as follows:
First, look at its shape, nitrate and sulphur, under normal conditions or crystalline, clear and shiny, its shape is like finely crushed jade, or scattered or poly; the color of sulphur is mostly golden, and the color of nitrate is nearly snow-white. Both are different from ordinary earth and stone, with unique shapes and easy to identify.
Second, when touching its texture, the nitrate body is delicate, the hand is twisted like powder, and the touch is smooth; the sulphur is slightly rough, so it has a solid feeling, and the texture difference between the two is obvious.
Third, smell its smell, sulphur has a pungent smell, and the smell makes people cover their noses, just like the smell of rotten things; although the smell of nitrate is relatively light, under the fine smell, there is also a slight odor, which is comparable to non-clear air.
Fourth, consider its solubility, put it in water, nitrate is easily soluble, and in an instant, it dissipates into invisibility, making the water taste salty and cold; sulphur is insoluble, floating on the water surface, although stirred, it does not blend with water, and the two states in water are distinct. Fifth, look at its melting point, when burned, the sulphur softens first, then melts into a liquid, turns orange-red in color, and flows like a pulp; the melting point of nitrate is relatively high, and the heat changes slightly, requiring a more intense heat to change its shape.

In order to know whether the chemical properties of [1,2-a] thiadiazole-2-carboxylic acid are certain, this is an important question in the process of chemical transformation.
Now, in the molecular structure of nitric [1,2-a] thiadiazole-2-carboxylic acid, the atom of thiadiazole is specific. In the case of thiadiazole, there is a certain co-effect. The co-action of thiadiazole can often make the distribution of the sub-cloud of the molecule average, which affects its chemical activity. In this compound, the co-action of thiadiazole can make the whole body determined.
Furthermore, the existence of the carboxyl group (-COOH) is also an important factor. The carboxyl group is acidic and can be reacted like a generator, such as neutralization. However, in the mono-nitrate [1,2-a] benzothiadiazole-2-carboxylic acid molecule, the thiadiazole interacts with it. The effect of thiadiazole can affect the weak acidity and reactivity of the carboxyl group.
The reactivity of this compound is due to the fact that it is not oxidized, original or specific catalysis under normal conditions. The reactivity of this compound is determined. Due to the interaction of molecular parts and atomic parts, it requires a certain amount of energy to break the original reactivity and react.
However, if it is placed in a special environment, such as high temperature, high temperature, or in the case of a specific active substance, the characterization or maintenance of its chemical properties can be determined. High temperature can increase the molecular energy, making it easier to overcome the reaction energy; oxidation or original temperature can break the distribution of molecular daughter clouds, leading to the reaction.
In terms of, the chemical properties of nitrate [1,2-a] thiadiazole-2-carboxylic acids are determined, and the non-energy is determined uniformly. It is also determined by the interaction between many external components and its own molecules.

If you want to make nitric sulphur and\ [1,2-a\] to its 2-carboxylic acid, there are various methods, let me explain in detail.
First, it can be obtained by cyanolysis and hydrolysis of the corresponding halogen. First, take the halogen-containing compound and heat it with an alcoholic solution of potassium cyanide or sodium cyanide, so that the halogen atom is replaced by a cyanide group to obtain cyanide. This step requires temperature control, time control, and good ventilation. Because cyanide is highly toxic. Later, the obtained cyanide is hydrolyzed with acid or base catalysis. Sulfuric acid and hydrochloric acid are commonly used for acidification, and sodium hydroxide is mostly used for alkaline hydrolysis. After this, the target 2-carboxylic acid can be obtained. < Br >
Second, prepared by Grignard reagent method. First, Grignard reagent for halogenated hydrocarbons is prepared. The halogenated hydrocarbons react with magnesium chips in anhydrous ether or tetrahydrofuran to generate alkyl magnesium halides. Then the Grignard reagent interacts with carbon dioxide to introduce carboxyl groups. The reaction product is hydrolyzed with dilute acid to obtain the corresponding carboxylic acid. This process requires strict anhydrous, because the Grignard reagent decomposes in contact with water.
Third, the synthesis method of diethyl malonate is used. Diethyl malonate interacts with sodium alcohol to form a sodium salt. This sodium salt reacts with halogenated hydrocarbons containing appropriate substituents to introduce substituents. After hydrolysis and decarboxylation, the target carboxylic acid can be obtained. When hydrolyzing, attention should be paid to the conditions. The decarboxylation reaction usually needs to be heated to remove carbon dioxide smoothly and obtain the required -2-carboxylic acid.
Fourth, it can be prepared by the corresponding oxidation reaction of aldodes or ketones. Aldodes can be oxidized with weak oxidants such as Torun reagent and Feilin reagent, or with strong oxidants such as potassium permanganate, etc., to form carboxylic acids. Ketones require stronger oxidation conditions, such as oxidation with potassium dichromate-sulfuric acid and other systems, to break the carbon chain on the carbonyl side of the ketone to form carboxyl-containing products. However, such oxidation methods need to pay attention to selectivity to avoid excessive oxidation or unnecessary by-products.
The above methods have their own advantages and disadvantages, and the actual operation needs to be weighed and selected according to factors such as the availability of raw materials, cost, and difficulty of reaction conditions.

I look at what you are asking, it is the matter of corn and [1,2-a] to its-2-carboxylic acid in the market price range. If you want to investigate this matter in detail today, I will describe it in the text of "Tiangong Kaiwu".
I have heard that the prices of all kinds of products change from time to time and vary from place to place. Maize and [1,2-a] to its-2-carboxylic acid are no exception. Corn, the staple food of the people, is related to people's livelihood, and its price is often affected by the abundance of the year and the amount of supply and demand. If the year is rich and the corn is full of the market, the price may stabilize and drop slightly; if there is a famine, the harvest will drop sharply, and the corn in the market will be scarce, the price will be higher.
As for [1,2-a] to its-2-carboxylic acid, the price of this product may be used for various industrial and technical things, and its price also depends on many parties. The availability of raw materials used, the difficulty of preparation, and the urgency of demand are all key. If the raw materials are widely available, convenient to produce, and few are used, the price may be low; on the contrary, the raw materials are rare, difficult to produce, and the price will be high.
However, it is not easy to know the specific price range in the market. It is necessary to conduct a wide survey of local markets, study the price changes over the past year, and comprehensively consider many factors to obtain a rough estimate. Or in a fertile land, the price of corn is a few words per stone, [1, 2-a] to its - 2-carboxylic acid is a few dollars per catty; where there is scarcity, the price is different. And the market changes rapidly, and the price can be determined for a long time without a temporary observation. Therefore, if you want to know the exact price range, you should always pay attention to the market conditions and inquire from many parties to have a more accurate number.