ethyl pyridine-4-carboxylate 1-oxide

Ethylpyridine-4-carboxylate 1-oxide, an organic compound, has important uses in many fields.
First, in the field of medicinal chemistry, it can be used as a key intermediate. The structure of Geinpyridine and carboxylate is widely present in many drug molecules, endowing the molecule with specific pharmacological activities and pharmacokinetic properties. By modifying the structure of ethylpyridine-4-carboxylate 1-oxide, various drugs with different curative effects can be synthesized, such as antibacterial, anti-inflammatory, and anti-tumor genera. Its oxide form may enhance molecular polarity, improve drug solubility and bioavailability, and is of great significance in the process of drug development.
Second, in the field of materials science, there are also applications. Pyridine compounds can participate in the construction of functional materials due to their unique electronic structure and coordination ability. Ethylpyridine-4-carboxylate 1-oxide may be used as a building block to prepare materials with specific photoelectric properties and adsorption properties through polymerization or self-assembly processes. For example, in organic optoelectronic materials, or the energy level structure of materials can be adjusted to improve luminous efficiency and stability, laying the foundation for the development of new optoelectronic devices.
Third, in the field of organic synthetic chemistry, it is an important reaction substrate. With its ester group and pyridine ring, it can participate in various reactions such as hydrolysis, alcoholysis, aminolysis, etc., providing an effective way for the construction of complex organic molecules. And the pyridine-N-oxide structure can activate the pyridine ring, making it more prone to nucleophilic substitution, expanding the organic synthesis strategy, and assisting the synthesis of organic compounds with specific structures and functions.

The synthesis method of 1-oxide of pyridine-4-carboxylic acid ester is often involved in the field of organic synthesis. There are many methods, and the following are the common methods.
First, pyridine-4-carboxylic acid is used as the initial raw material. First, pyridine-4-carboxylic acid and ethanol are esterified under the condition of acid catalysis. Acids, such as concentrated sulfuric acid or p-toluenesulfonic acid. At an appropriate temperature, such as heating and refluxing state, the carboxylic acid and ethanol can react to form ethyl pyridine-4-carboxylic acid. Then, the obtained ethyl pyridine-4-carboxylic acid is treated with an appropriate oxidizing agent. Commonly used oxidizing agents are hydrogen peroxide, m-chloroperoxybenzoic acid, etc. In a suitable reaction environment, such as a suitable solvent, through this oxidation step, the nitrogen atom on the pyridine ring can be oxidized to nitrogen oxide, and the final product is ethylpyridine-4-carboxylate 1-oxide.
Second, 4-cyanopyridine can also be used as a starting material. First, 4-cyanopyridine is reacted with ethanol in the presence of a base catalyst and a nucleophilic reagent. In this step, the ethanolysis of the cyanyl group can be achieved to generate an analogue of pyridine-4-carboxylate ethyl ester. Sodium alcohol and the like can be selected for the base. Subsequently, as in the previous method, the nitrogen atom of the pyridine ring is oxidized with an oxidizing agent such as hydrogen peroxide, and the target product can also be obtained through this series of reactions.
Third, the desired structure can also be constructed from the pyridine derivative through a multi-step reaction. If a specific substitution reaction is carried out on the pyridine ring first, a suitable substituent is introduced to facilitate the subsequent construction of ethyl ester groups and oxidation to nitrogen oxides. This process requires careful design of the reaction sequence and conditions according to the reactivity and localization effect of the pyridine ring. For example, the halogen atom is first introduced at a specific position in the pyridine ring, and then the ethyl ester-containing fragment is connected through the nucleophilic substitution reaction, and finally the oxidation of the nitrogen atom is completed, so as to achieve the synthesis of ethyl pyridine-4-carboxylate 1-oxide. These methods have their own advantages and disadvantages, and the practical application needs to be weighed according to the availability of raw materials, the difficulty of controlling the reaction conditions, and the yield.

Ethylpyridine-4-carboxylate 1-oxide is a kind of organic compound. Looking at its physical properties, it can be either solid or liquid at room temperature, but the exact state depends on its specific structure and the conditions of the surrounding environment.
In terms of its melting point, this compound may have a relatively high melting point. Due to strong interactions between molecules, such as hydrogen bonds, van der Waals forces, etc., higher temperatures are required to break its lattice structure and make it melt.
As for the boiling point, the boiling point of ethylpyridine-4-carboxylate 1-oxide is also quite high. In its molecular structure, the polar part interacts with the non-polar part to form a certain intermolecular force, which makes the binding between molecules stronger. To make it boil and vaporize, more energy is required, so the boiling point is not low.
In terms of solubility, it may exhibit a certain solubility in organic solvents. The polarity and molecular structure of organic solvents match each other with the compound, and they can be dissolved by the principle of similar compatibility. However, the solubility in water may vary depending on the degree of polarity of the compound and the interaction between water molecules. If the polar part accounts for a large proportion and can form hydrogen bonds with water molecules, it may have a certain solubility in water; conversely, if the non-polar part dominates, it may have a certain solubility in water.
In addition, the density of the compound may be similar to that of common organic compounds. The density is also determined by the mass of its molecules and the degree of close arrangement between molecules. Its appearance, either colorless and transparent, or a certain color, is related to its purity and molecular structure on light absorption and scattering characteristics.
From the above, the physical properties of ethylpyridine-4-carboxylate 1-oxide are affected by its molecular structure, intermolecular forces and many other factors, showing diverse characteristics.

Ethylpyridine-4-carboxylate-1-oxide, this is one of the organic compounds. Its chemical properties are unique and of great research value.
First of all, its physical properties, at room temperature, or in a solid state, may have certain solubility due to the substituent and molecular structure. In organic solvents, such as common ethanol, ether, etc., may exhibit different solubility characteristics, which are caused by differences in intermolecular forces.
On chemical properties, because it contains ester groups, it has the typical reaction of esters. Hydrolysis can occur under the catalytic conditions of acids or bases. In an acidic environment, the hydrolysis reaction may be relatively mild, and after a gradual hydrolysis process, the corresponding carboxylic acids and alcohols are generated. Under alkaline conditions, the hydrolysis reaction is often more rapid and thorough, resulting in carboxylic salts and alcohols. This hydrolysis reaction has a wide range of uses in the field of organic synthesis, and can be used to prepare specific carboxylic acids.
Furthermore, the pyridine ring in the molecule also gives it unique chemical activity. Pyridine ring has a certain alkalinity and can react with acids to form pyridine salts. At the same time, the electron cloud distribution on the pyridine ring is special, which makes it able to participate in various electrophilic and nucleophilic substitution reactions. In electrophilic substitution reactions, the reaction check point is mostly affected by the electronic and spatial effects of substituents on the pyridine ring. In nucleophilic substitution reactions, the pyridine ring can act as a check point for nucleophilic reagents, or react with other electrophilic reagents to construct more complex organic molecular structures.
In addition, the nitrogen oxide fraction of the compound adds additional electronic and spatial effects to the molecule, affecting the reactivity and stability of the molecule as a whole. This nitrogen oxide fraction can participate in redox reactions. Under specific conditions, either a reduction reaction occurs, changing back to the pyridine structure, or participating in further oxidation reactions to generate more complex nitrogen-containing oxygen compounds. < Br >
The chemical properties of this compound are rich and diverse, and it has potential application value in many fields such as organic synthesis and medicinal chemistry, or can become an important intermediate for the preparation of new drugs and functional materials.

I don't know what the price range of "ethyl+pyridine+-+4+-+carboxylate+1+-+oxide" is in the market. This is a fine chemical product, and its price often varies depending on the quality, purity, supplier, quantity, and supply and demand of the market.
In the world of "Tiangong Kaiwu", there were no such fine chemicals. At that time, the chemical industry was not as developed as it is today, and it was mostly created by natural things and simple methods. However, today is different from the past. Chemical synthesis is advanced, and the use of such compounds is becoming more and more widespread.
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