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What is the chemical structure of ethyl methyl 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate?
Alas! This is a chemical nomenclature. If you want to know its structure, you should investigate its name in detail. "Ethyl" is ethyl; "methyl" is methyl; "2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate", this part is the description of the core structure.
From the name, it can be seen that this compound contains a variant of the pyridine ring, and the 1,4-dihydropyridine structure is its basis. The 2nd and 6th positions are connected with methyl groups, and the 4th positions are connected with 3-nitrophenyl groups. The 3rd and 5th positions of the pyridine ring are each connected to a carboxylic acid ester, one is an ethyl ester group, and the other is a methyl ester group.
If its structure is drawn, first draw the hexa- membered ring of 1,4-dihydropyridine, add methyl at the 2nd and 6th positions, connect 3-nitrophenyl at the 4th position, and then connect ethyl and methyl ester at the 3rd and 5th positions, respectively. In this way, the chemical structure of this compound is clear.
What are the physical properties of ethyl methyl 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate?
Ethylmethyl 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate, this is an organic compound. Its physical properties are rich and diverse, and it is of great significance to chemistry, medicine and other fields.
Looking at its appearance, it is usually in a crystalline solid state, dense and has a regular lattice structure, which is due to the orderly arrangement of intermolecular forces. The color may be white to light yellow, and the purity of the color is often related to the purity. Impurities affect its color. If the purity is high, the color will be light. < Br >
In terms of melting point, the compound has a specific melting point range, or between 150 and 160 ° C. At this temperature, the molecule obtains enough energy, the lattice structure disintegrates, and the solid state turns to a liquid state. Melting point determination is a common means to identify purity and material properties. When impurities are present in the compound, the melting point may drop and the melting range becomes wider.
Solubility is also an important physical property. In organic solvents, such as ethanol, acetone, and chloroform, it exhibits good solubility. Due to the similar principle of miscibility, the force between organic molecules and organic solvent molecules is strong. However, in water, due to the dominant structure of hydrophobic groups, the solubility is poor. This property is crucial for the separation, purification, and solution preparation of compounds. < Br >
The density is related to the unit volume mass, and its density may be between 1.2 and 1.3 g/cm ³. Although it is not extremely heavy, it is higher than that of common organic solvents. Density determination helps to determine the proportion of liquid mixture components and quantitative analysis of compounds.
Volatility is weak, and it is not easy to evaporate under normal conditions. Due to strong intermolecular forces, it is difficult for molecules to break free and enter the gas phase. This property makes it stable during storage and use, and it is not easy to lose or change concentration due to volatilization.
The physical properties of ethylmethyl 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate are widely used in chemical synthesis, drug development and many other fields. Understanding and mastering these properties is the key to the rational use of this compound.
What are the synthesis methods of ethyl methyl 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate?
The methods for synthesizing ethylmethyl 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate are generally as follows.
One is based on the Hantzsch reaction. This reaction is a classic method, usually using ethyl acetoacetate, 3-nitrobenzaldehyde and ammonia or ammonium salt as raw materials, in an alcohol solvent, heated and refluxed. During this process, the aldehyde and two molecules of β-ketoate are first condensed, and then cyclized with ammonia to obtain the target product. This process requires attention to the control of reaction temperature, raw material ratio and reaction time. If the temperature is too low, the reaction will be slow; if it is too high, the side reaction will occur. Improper proportion of raw materials also affects the yield.
Second, microwave-assisted synthesis method. Under microwave radiation, the reaction process is accelerated. Compared with traditional heating, microwaves can make molecules vibrate and collide rapidly, so that the reaction system can quickly reach the required temperature and be heated evenly. In this way, the reaction time is greatly shortened and the yield may be improved. However, special microwave equipment is required, which requires high precision regulation of reaction conditions.
Third, metal catalytic synthesis method. Specific metal catalysts can be selected, such as some transition metal complexes. Metal catalysts can reduce the activation energy of the reaction and promote the reaction. It can change the reaction path and make the reaction more efficient. However, it is crucial to choose the appropriate catalyst, control the amount of catalyst and the pH, temperature and other conditions of the reaction environment. Due to the activity and selectivity of the catalyst, the purity and yield of the product are greatly affected.
These three synthesis methods have their own advantages and disadvantages. The Hantzsch reaction is classic and mature, but it takes time or time; the microwave-assisted synthesis is efficient and fast, and the equipment requirements are high; the metal catalysis has the advantage of selectivity, and the condition control is complicated. When synthesizing, it is necessary to choose the appropriate method according to the actual situation, such as the availability of raw materials, equipment conditions, product requirements, etc.
What are the application fields of ethyl methyl 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate?
Ethyl methyl 2,6 - dimethyl - 4 - (3 - nitrophenyl) -1,4 - dihydropyridine - 3,5 - dicarboxylate (Chinese name: 2,6 - dimethyl - 4 - (3 - nitrophenyl) -1,4 - dihydropyridine - 3,5 - dicarboxylate methyl ester), this compound is a class of compounds with a special structure and is used in many fields. The following is a detailed description:
- ** Pharmaceutical field **: This compound belongs to the 1,4 - dihydropyridine class and is an important calcium ion channel blocker. It can regulate the calcium ion influx by precisely regulating the calcium ion channel on the cell membrane. In the cardiovascular system, it can relax the smooth muscle of blood vessels, reduce the resistance of peripheral blood vessels, and then effectively reduce blood pressure, so it is often used in the treatment of hypertension. And because it can increase coronary blood flow and relieve myocardial ischemia, it is also a common drug for the treatment of angina pectoris. Classic drugs such as nifedipine and amlodipine belong to this category, while ethyl methyl 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dipyhydroridine-3,5-dicarboxylate or has similar pharmacological activities, it has the potential to be developed into a drug for the treatment of cardiovascular diseases. < Br > - ** Field of Organic Synthesis **: Its unique structure contains dihydropyridine rings and functional groups such as ester groups and nitro groups, which can be used as key intermediates to participate in the construction of complex organic molecules. Dihydropyridine rings can be converted into pyridine rings or other nitrogen-containing heterocyclic structures by oxidation, reduction and other reactions. Ester groups can undergo hydrolysis, alcoholysis, aminolysis and other reactions to introduce different functional groups or structural fragments, laying the foundation for the synthesis of new drugs, natural products and functional materials. For example, by reacting with compounds containing active hydrogen, derivatives with specific biological activities or material properties can be prepared. < Br > - ** Materials Science Field **: Due to the presence of conjugated structures and reactive functional groups in molecules, or with special optical and electrical properties. The conjugated system may give it certain fluorescence properties, which can be used to prepare fluorescent probes for biological imaging or chemical sensing to detect specific ions and molecules. At the same time, after appropriate modification, it may be used as an organic semiconductor material for optoelectronic devices such as organic light emitting diodes (OLEDs) and organic field effect transistors (OFETs), providing new options for the development of materials science.
What is the market outlook for ethyl methyl 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate?
"Tiangong Kaiwu" is a scientific and technological masterpiece written by Song Yingxing in the Ming Dynasty. Its style of writing is simple and the words are exquisite. Today, the answer to this question is described in ancient Chinese.
Ethylmethyl 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate, this chemical is quite promising in the current market prospect. It is in the field of medicine, or a key raw material for the creation of new cardiovascular drugs. At present, cardiovascular diseases are raging, and there are many patients, so there is a demand for related therapeutic drugs. Based on this chemical, the drugs produced may have unique pharmacological activities, which can accurately act on the cardiovascular system, regulate blood pressure, heart rate, and improve cardiac function. Therefore, it is expected to emerge in the pharmaceutical market and be favored by doctors and patients. The market potential is huge.
In the field of materials science, there are also opportunities for development. Its special chemical structure may endow materials with novel properties. If used to prepare functional polymer materials, the materials can have unique optical and electrical properties, and can be used in cutting-edge fields such as optoelectronic devices and sensors. With the rapid development of science and technology, the demand for such high-performance materials is increasing day by day. As a potential raw material, this chemical has broad market prospects.
However, its market development is not smooth. The process of synthesizing this chemical may be complicated and costly, limiting its large-scale production. And the entry of new chemicals into the market requires strict security evaluation and regulatory approval, which is time-consuming and laborious. However, with time, advanced scientific research, process improvement, cost reduction, and breaking through regulatory barriers, ethylmethyl 2,6-dimethyl-4 - (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate will be able to shine in the market and inject strong impetus into the development of related industries.