Ethyl 6 Chloro 1h Pyrrolo 2 3 B Pyridine 1 Carboxylate
pyridine pyrrole pyrazine piperidine piperazine

Ethyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

    Specifications

    HS Code

    457450

    Chemical Formula C10H9ClN2O2
    Molecular Weight 224.644 g/mol
    Appearance Solid (usually)
    Physical State At Room Temperature Solid
    Solubility In Water Low solubility (organic compound with limited polar groups)
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Stability Stable under normal conditions, may be sensitive to strong acids, bases, and oxidizing agents

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    Where to Buy Ethyl 6-chloro-1H-pyrrolo[2,3-b]pyridine-1-carboxylate in China?
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    What is the chemical structure of Ethyl 6-chloro-1H-pyrrolo [2,3-b] pyridine-1-carboxylate
    Ethyl+6-chloro-1H-pyrrolo%5B2%2C3-b%5Dpyridine-1-carboxylate is an organic compound, and its chemical structure can be deduced according to its English name. "Ethyl" is ethylethyl, which is - C 2O H, and is often used as a part of the ester group. "6-chloro" refers to the substitution of chlorine atoms at position 6 of the main structure, and the chlorine atoms are represented by - Cl. "1H-pyrrolo%5B2%2C3-b%5Dpyridine" indicates that the main structure of this compound is pyrrolido [2,3 - b] pyridine, which is a bilicyclic structure formed by fusing pyrrole rings with pyridine rings. "1-carboxylate" means that there is an ester group derived from a carboxyl group at position 1. Combined with "Ethyl", it can be known as carboxylic acid ethyl ester group, that is, - COOCH < unk > CH < unk > is connected to position 1 of the main structure.
    To sum up, the chemical structure of the Ethyl+6-chloro-1H-pyrrolo%5B2%2C3-b%5Dpyridine-1-carboxylate contains pyrrolido [2,3-b] pyridine double ring, with a chlorine atom at position 6 and a carboxylate ethyl group at position 1. Its structure is as follows: with the fused pyrrolido [2,3-b] pyridine as the core, it extends at position 1 - COOCH ² CH 🥰, position 6 - Cl, and the rest of the ring distributes hydrogen atoms according to the carbon valence and hydrogen atom saturation rules. In this way, the chemical structure of this compound can be clarified.
    What are the main uses of Ethyl 6-chloro-1H-pyrrolo [2,3-b] pyridine-1-carboxylate
    Ethyl 6-chloro-1H-pyrrolo [2,3-b] pyridine-1-carboxylate is an organic compound. It has a wide range of uses and is of great significance in the field of medicinal chemistry.
    Looking at the end of drug development, this compound often acts as a key intermediate. Taking the creation of new anti-tumor drugs as an example, with its unique chemical structure, many derivatives with potential biological activity can be derived. By modifying its structure, chemists are expected to find compounds that can precisely act on specific targets of tumor cells, thereby interfering with tumor cell growth, proliferation and metastasis, providing new opportunities to solve cancer problems.
    It can also be seen in the exploration of antibacterial drugs. After appropriate chemical modification, substances with significant inhibitory effects on specific pathogens may be obtained. Some key links in the synthesis or metabolism of bacterial cell walls may be blocked by such compounds derived from Ethyl 6-chloro-1H-pyrrolo [2,3-b] pyridine-1-carboxylate, thereby inhibiting bacterial growth and reproduction, providing a different way to deal with bacterial infections.
    Furthermore, in the field of materials science, this compound may also emerge. In the preparation of organic optoelectronic materials, its special structure may endow materials with unique optoelectronic properties. For example, in the development of organic Light Emitting Diode (OLED) materials, by introducing them into the material system, key parameters such as material luminous efficiency and stability can be optimized, which can help the further development of OLED technology and bring new changes to the display field.
    In short, Ethyl 6-chloro-1H-pyrrolo [2,3-b] pyridine-1-carboxylate has great application potential in fields such as medicine and materials science, waiting for researchers to further explore and explore.
    What are the synthesis methods of Ethyl 6-chloro-1H-pyrrolo [2,3-b] pyridine-1-carboxylate
    Ethyl 6 - chloro - 1H - pyrrolo [2,3 - b] pyridine - 1 - carboxylate is an important organic compound, and its synthesis method is quite critical. Common synthesis methods can be made from starting materials with corresponding structures and through multi-step reactions.
    First, you can take suitable pyridine derivatives and introduce chlorine atoms at 6 positions under specific conditions. This step requires careful selection of chlorination reagents, such as commonly used phosphorus oxychloride. During the reaction, the reaction temperature, time and reagent dosage must be strictly controlled to ensure that chlorine atoms are accurately introduced into the desired position and to avoid excessive chlorination or other side reactions.
    Then, at the appropriate check point of the pyridine ring, the pyrrole ring is constructed by a specific reaction. This process often requires the help of some nitrogenous and carbon-derived reagents, under the action of bases or catalysts, through cyclization to form a pyrrole structure. For example, nitrogen-containing nucleophiles can be used to react with active groups on pyridine derivatives to form 1H-pyrrolo [2,3-b] pyridine structures through molecular close rings.
    As for the introduction of carboxyethyl ester groups, generally after the construction of the pyrrolidine structure, the corresponding carboxylic acid derivatives, such as acyl chloride or anhydride, are esterified with ethanol under base catalysis, so as to introduce Ethyl 1-carboxylate structure at 1 position. During the reaction, attention should be paid to the type and dosage of bases to avoid damage to the formed pyrrolidine structure.
    In addition, during the synthesis process, the separation and purification of the reaction products at each step is also crucial. Commonly used methods include column chromatography, recrystallization, etc., to ensure the purity of the product at each step, laying a good foundation for subsequent reactions, and finally high-efficiency synthesis of Ethyl 6-chloro-1H-pyrrolo [2,3-b] pyridine-1-carboxylate.
    What are the physical properties of Ethyl 6-chloro-1H-pyrrolo [2,3-b] pyridine-1-carboxylate
    Ethyl 6 - chloro - 1H - pyrrolo [2,3 - b] pyridine - 1 - carboxylate is an organic compound. Its physical properties are as follows:
    1. ** Appearance **: Usually solid or liquid, but the exact appearance varies depending on its purity and conditions. If it is solid, or crystalline, with a regular crystalline shape, the texture may be fine; if it is a liquid, it can be regarded as a clear or microcolored fluid.
    2. ** Melting Point and Boiling Point **: The values of the melting point and boiling point are crucial for the identification and purification of this compound. The melting point characterizes the temperature at which a substance changes from solid to liquid, and the boiling point is the temperature at which it changes from liquid to gas. Sadly, without specific experimental data, it is difficult to accurately state the melting and boiling point of this compound.
    3. ** Solubility **: The solubility of organic solvents is good, such as common ethanol, acetone, dichloromethane, etc. Because its structure contains specific functional groups, it may interact with organic solvent molecules such as hydrogen bonds and van der Waals forces, resulting in their solubility. However, the solubility in water may be limited, because it is not a highly polar compound, the interaction with water molecules is weak.
    4. ** Density **: The density reflects the mass of the substance per unit volume. Although there is no exact data, it can be speculated from its molecular structure and similar compounds. Generally speaking, its density may be between common organic solvents and water, and the specific value depends on accurate measurement.
    5. ** Color and odor **: The color of pure matter may be nearly colorless, if it contains impurities, or slightly colored. In terms of odor, or the smell of specific organic compounds, but due to the presence of nitrogen, chlorine and other atoms in the structure, the smell may have a certain uniqueness, and the exact smell needs to be actually smelled and perceived.
    What is the price range of Ethyl 6-chloro-1H-pyrrolo [2,3-b] pyridine-1-carboxylate in the market?
    I look at your question and ask "Ethyl 6 - chloro - 1H - pyrrolo [2,3 - b] pyridine - 1 - carboxylate" in the market price range. However, the change in the price of this chemical product depends on many factors.
    First, it is difficult to prepare. If the synthesis method is complicated, rare reagents are required, or the steps are lengthy, the cost will be high, and the price will be high.
    Second, the difference in purity. High purity, less impurities, suitable for high-end scientific research or special industrial use, the price is higher than that of low purity. Low purity, or only for general basic research, the price is slightly cheaper.
    Third, market supply and demand. If there are many people who need it, but there are few producers, the supply will exceed the demand, and the price will rise; on the contrary, if the supply exceeds the demand, the price will decline.
    Fourth, production scale. Large-scale production, due to the scale effect, the unit cost may be reduced, and the price is expected to be slightly lower; small-scale production, the cost is difficult to reduce, and the price is often higher.
    Overall, I am not sure about this specific price range. If you want to know more, you can consult chemical raw material suppliers, chemical reagent sellers, or check relevant chemical product trading platforms to get accurate prices.