ethyl 6-bromopyridine-3-carboxylate

Ethyl-6-bromopyridine-3-carboxylic acid esters are key intermediates commonly used in organic synthesis. They have a wide range of uses and are described below.
First and foremost, in the field of medicinal chemistry, they can be used as the basic structure for constructing a variety of drug molecules. Due to the characteristics of pyridine rings, ester groups and bromine atoms, different functional groups can be introduced through various chemical reactions, such as nucleophilic substitution, coupling reactions, etc., to create compounds with specific biological activities. For example, by nucleophilic substitution reaction with nucleophilic reagents such as nitrogen and oxygen, nitrogen-containing heterocyclic or ether structures are constructed, which are commonly found in many pharmacologically active drug molecules, such as antibacterial, anti-inflammatory, anti-tumor and other drugs.
Secondly, in the field of materials science, it also has its uses. Through appropriate reactions, it can be introduced into the skeleton of polymer materials to impart specific properties to the materials. For example, by using the activity of bromine atoms, polymerization reactions or other connection methods, polymer materials with special photoelectric properties can be prepared, which can be used as organic Light Emitting Diodes (OLEDs), solar cells and other materials to improve the properties of materials such as charge transport and luminous efficiency.
Furthermore, in the synthesis of fine chemicals, ethyl-6-bromopyridine-3-carboxylic acid esters are also important raw materials. It can be used in the synthesis of fine chemicals such as fragrances and dyes. Such as modifying its structure through subsequent reactions to prepare compounds with specific colors or aromas to meet the needs of fine chemicals in different industries.
In short, ethyl-6-bromopyridine-3-carboxylic acid esters play an important role in many fields such as drugs, materials, and fine chemicals, providing important support for the development of organic synthetic chemistry and the progress of related industries.

There are several common methods for synthesizing ethyl 6-bromopyridine-3-carboxylate (6-bromopyridine-3-carboxylate).
One is to use 6-hydroxypyridine-3-carboxylate as the starting material. This hydroxyl compound reacts with a bromine-containing reagent to introduce bromine atoms. Bromine-containing reagents such as phosphorus tribromide ($PBr_3 $) are commonly used. 6-hydroxypyridine-3-carboxylate is placed in a suitable solvent, such as anhydrous ethyl ether or dichloromethane, and phosphorus tribromide is slowly added dropwise at low temperature. During the reaction, the hydroxyl group is replaced by a bromine atom to form the target product 6-bromopyridine-3-carboxylic acid ethyl ester. The reaction conditions are mild and the yield is quite high. However, phosphorus tribromide is corrosive, so caution is required during operation.
Second, pyridine-3-carboxylic acid ethyl ester is used as the starting material. The pyridine ring is brominated first. Liquid bromine can be used to react under the catalysis of Lewis acid, commonly used Lewis acid such as aluminum trichloride ($AlCl_3 $). Pyridine-3-carboxylic acid ethyl ester and an appropriate amount of liquid bromine and aluminum trichloride are placed in a halogenated hydrocarbon solvent, such as dichloro In the reaction, the bromine atom selectively replaces the 6-position hydrogen atom of the pyridine ring to obtain ethyl 6-bromopyridine-3-carboxylate. However, this reaction needs to control the amount of bromine and the reaction temperature, otherwise it is easy to produce polybrominated by-products.
Third, 6-aminopyridine-3-carboxylate is used as the raw material. The amino group is first diazotized, and then the bromine atom is introduced through the Sandmeyer reaction. Sodium nitrite is reacted with 6-aminopyridine-3-carboxylate ethyl ester under acidic conditions to form a diazonium salt. Afterwards, cuprous bromide ($CuBr $) is added, and the diazo group is replaced by a bromine atom to generate ethyl 6-bromopyridine-3-carboxylate. This method is a little more complicated, but the selectivity is good, which is suitable for the situation where the purity of the product is strict.

Ethyl 6-bromopyridine-3-carboxylate, Chinese name for ethyl 6-bromopyridine-3-carboxylate. This substance is a chemical compound with general physical properties.
Its external color is usually light to liquid color, and it usually exists under normal conditions. In terms of melting, it is usually at a low temperature, between -10 ° C and 10 ° C. This property makes it liquid under normal conditions. Its boiling phase is high, probably between 250 ° C and 270 ° C. This boiling reflects the weak molecular force, and high energy is required to make it melt from liquid.
Until the density is between 1.45 and 1.55 g/cm ³, the density of water is large, so if the water is mixed, it will sink to the bottom of the water. This substance has special solubility and is slightly soluble in water. In its molecules, the molecular phase is small, and it forms a strong interaction with water molecules. However, it is soluble in many soluble molecules, such as ethanol, ether, dichloromethane, etc., because the molecular forces of the soluble molecules are similar, which conforms to the principle of similar miscibility.
Furthermore, ethyl 6-bromopyridine-3-carboxylate has certain properties, but its speed is slow, because the molecular force is enough to limit the escape of the molecular liquid from the surface. And its smell is weak, non-pungent, slightly fragrant, but at high temperatures, the taste is slightly stronger. Its refractive index is also a specific value, with a range of 1.550-1.570. This physical property can be used for the analysis of substances, and is of great significance in the field of optical research and phase analysis.

The market price of ethyl 6-bromopyridine-3-carboxylate, a chemical in the field of fine chemicals, is ethyl 6-bromonicotinate. Its market price is not constant and often fluctuates due to a variety of reasons.
The first to bear the brunt is the cost of raw materials. The preparation of ethyl 6-bromonicotinate requires specific raw materials, such as 6-bromonicotinic acid, ethanol, etc. If the supply of such raw materials is in short supply, or the production area changes, such as natural disasters, man-made disasters, or a large increase in market demand, the price of raw materials can rise, which in turn will increase the cost of ethyl 6-bromonicotinate and the price will also rise.
Furthermore, the production process and technical level have a great impact. Advanced production technology can improve production efficiency and reduce production costs. If a factory develops a better process that can produce with lower energy consumption and higher yield, its product price may be competitive. However, if the process is backward, the production process is complex, the energy consumption is high, and the yield is low, the cost will be high and the price will be high.
The relationship between supply and demand in the market is also key. If the market demand for 6-bromo nicotinate ethyl ester is strong, such as the pharmaceutical industry's demand for it, and the supply is limited, the price will rise. On the contrary, if the market is saturated and the supply far exceeds the demand, the manufacturer will sell or reduce the price.
In addition, regional differences cannot be ignored. Different regions have different prices due to different transportation costs, tax policies, and market competition. If the transportation cost is high in places with inconvenient transportation, the price may be higher than that in places with convenient transportation; in areas with loose tax policies, the product price may be more advantageous due to cost reduction.
There are product quality factors. High-purity, high-quality 6-bromo-nicotinate ethyl ester, due to the difficulty of production, the price is often higher than that of ordinary quality.
To know the exact market price, check the chemical product trading platform in detail and consult the relevant chemical distributors or manufacturers to obtain accurate and real-time price information.

Ethyl + 6 - bromopyridine - 3 - carboxylate is a chemical substance, the Chinese name is or ethyl 6 - bromopyridine - 3 - carboxylate. During storage and transportation, many matters need to be paid attention to.
Let's talk about storage first. This substance should be placed in a cool, dry and well-ventilated place. Because it may be sensitive to heat and humidity, if the environment is hot, it may deteriorate and damage its chemical properties. And keep away from fires and heat sources to prevent fires or chemical reactions. Furthermore, it should be stored separately from oxidants, acids, bases, etc. Because of its chemical activity, if mixed with these substances, or react violently, it will endanger safety. The storage area should also be equipped with suitable containment materials to deal with possible leaks.
As for transportation, it should not be taken lightly. Make sure that the packaging is complete before transportation to prevent leakage during transportation. Choose suitable transportation tools to avoid mixing with other contraindicated chemicals. During transportation, care should be taken to avoid vibration, impact and friction to prevent package damage. And transportation personnel should be familiar with the characteristics of the substance and emergency treatment methods, and can respond quickly in case of emergencies. At the same time, transportation vehicles need to be equipped with corresponding fire equipment and leakage emergency treatment equipment to ensure safe transportation.