Ethyl 6-bromopyridine-2-carboxylate

Ethyl-6-bromopyridine-2-carboxylate, this substance has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the synthesis of many drugs. The carboxyl-group structure of geinpyridine gives the compound unique activity and binding characteristics, and can interact with specific targets in organisms. By modifying the pyridine ring and bromine atom, the physicochemical properties of drug molecules, such as lipophilicity, water solubility and metabolic stability, can be adjusted to improve the efficacy and safety of drugs.
In the field of pesticides, ethyl-6-bromopyridine-2-carboxylate also plays an important role. It can be chemically converted into compounds with insecticidal, bactericidal or herbicidal activities. The pyridine ring structure can enhance its affinity and selectivity to specific receptors or enzymes of pests, thus effectively inhibiting the growth and reproduction of pests and ensuring the healthy growth of crops.
In addition, in the field of materials science, this compound can participate in the synthesis of functional materials. With its unique structure, or specific functional groups can be introduced to endow materials with special properties, such as fluorescence and electrical conductivity. It is often used as a starting material or intermediate in organic synthesis, and complex organic molecular structures are constructed through various reactions, providing a basis for the creation of new substances. In short, ethyl-6-bromopyridine-2-carboxylate plays an important role in many fields, promoting the development and innovation of related fields.

There have been many attempts to prepare ethyl 6-bromo-pyridine-2-carboxylic acid esters in the past. One method is to first esterify pyridine-2-carboxylic acid and ethanol under the catalysis of concentrated sulfuric acid to obtain ethyl pyridine-2-carboxylic acid. This process requires attention to the reaction temperature and time. If the temperature is too high, side reactions will occur, and if the time is insufficient, the esterification will be incomplete. Then, pyridine-2-carboxylic acid ethyl ester and bromine are reacted in a suitable solvent under appropriate conditions. Usually carbon tetrachloride is used as a solvent, at low temperature and in the presence of catalysts such as iron powder, bromine and ethyl pyridine-2-carboxylate undergo electrophilic substitution reaction, and bromine atoms are mainly introduced at the 6-position of the pyridine ring to obtain ethyl 6-bromopyridine-2-carboxylate. However, the amount of bromine in this process needs to be paid attention to, and excess bromine can easily lead to the formation of polybrominated products.
There is another method, using 6-bromopyridine-2-carboxylic acid as the starting material, directly esterification reaction with ethanol under the action of dehydrating agent and catalyst. Commonly used dehydrating agents such as dicyclohexyl carbodiimide (DCC) and catalysts such as 4-dimethylaminopyridine (DMAP). This reaction condition is relatively mild and can reduce side reactions. During the reaction, the proportion of each reactant and the reaction environment should be precisely controlled, and the anhydrous environment is preferred, otherwise the esterification reaction will proceed in reverse and the yield will be reduced.
Furthermore, the pyridine ring can be modified first to activate the 6-position, and then esterified. If the activated group is introduced before the pyridine ring, the density of the 6-position electron cloud will be changed, which is conducive to the subsequent bromination and esterification reactions. However, the selection and subsequent removal of the activated group need to be carefully considered, so as not to affect the purity and yield of the product.

Ethyl 6-bromopyridine-2-carboxylate is an organic compound with unique physical properties. It is a solid or liquid, and it shows certain stability due to the molecular structure containing aromatic rings and ester groups.
Under normal temperature and pressure, it is either a colorless to light yellow liquid or a crystalline solid, depending on environmental conditions. The melting point and boiling point of this compound are quite critical. The melting point may vary depending on the intermolecular force. The interaction between aromatic rings and ester groups makes the molecules arranged in an orderly manner, and the melting point is relatively high. The boiling point is related to the intermolecular force and molecular weight. Due to the heavier bromine atoms and ester groups, the intermolecular force is enhanced, and the boiling point may be in a higher range.
In terms of solubility, Ethyl 6-bromopyridine-2-carboxylate has certain hydrophobicity due to its ester group and aromatic ring, and its solubility in water is limited. However, it can be soluble in a variety of organic solvents, such as common ethanol, ether, dichloromethane, etc. This is because the organic solvent and the compound can form similar forces between molecules, which is conducive to mutual dissolution.
Density is also an important physical property. Because its molecules contain bromine atoms, the atomic weight is large, resulting in a higher overall density or than that of common organic solvents. Density reflects the mass per unit volume of a substance and is of great significance for its separation, purification and application.
The physical properties of Ethyl 6-bromopyridine-2-carboxylate, such as its properties, melting point, boiling point, solubility, and density, are determined by its molecular structure and affect its use and operation in organic synthesis, drug discovery, and other fields.

Ethyl 6-bromopyridine-2-carboxylate is an organic compound with unique chemical properties and is very important in the field of organic synthesis.
This compound has two key functional groups: ester group and bromine atom. Among the ester groups, the hydrolysis reaction can occur under the catalysis of acid or base. Under acidic conditions, the hydrolysis produces 6-bromopyridine-2-carboxylic acid and ethanol; under alkaline conditions, like co-heating with sodium hydroxide solution, the sodium salt of 6-bromopyridine-2-carboxylate and ethanol will be formed. After acidification, this sodium salt also gives 6-bromopyridine-2-carboxylic acid.
Furthermore, its bromine atom activity is quite high. Nucleophilic substitution reactions can occur. When it meets nucleophilic reagents, such as sodium alcohol, amines, etc., bromine atoms will be replaced by corresponding groups to form new compounds. For example, when reacted with sodium methoxide, bromine atoms will be replaced by methoxy groups to obtain ethyl 6-methoxypyridine-2-carboxylate. Moreover, in the presence of appropriate catalysts, it can participate in metal-catalyzed coupling reactions, such as Suzuki coupling reactions, and form carbon-carbon bonds with boron-containing reagents under the action of palladium catalysts to realize the functionalization of pyridine rings, providing the possibility for the construction of more complex organic molecular structures. < Br >
The pyridine ring part is alkaline due to the presence of nitrogen atoms, and can react with acids to form salts. This property will be reflected in specific reaction conditions and separation and purification processes. In short, Ethyl 6-bromopyridine-2-carboxylate has been widely used in many fields such as drug synthesis and material chemistry due to these chemical properties.

Looking at this question, I am inquiring about the price range of ethyl 6-bromopyridine-2-carboxylate in the market. However, the price of the market often varies according to time, place, quality and supply and demand conditions, so it is difficult to determine its price.
In the past, if you ask for it in the chemical raw material market, the price may depend on the purity. High purity, the price must be high; purity is slightly lower, the price may be slightly cheaper. And the purchase quantity also affects the price. Purchase in large quantities, or the price is low due to the benefits of wholesale; buy in small quantities, or the price is high due to retail.
Furthermore, the price varies in different regions. In the place of origin, the price may be relatively easy; in remote areas, due to the cost of transportation and circulation, the price may increase. Times change, and the state of market supply and demand also changes frequently. If demand is strong and supply is small, the price will rise; if supply exceeds demand, the price will be depressed.
For details, you can visit the chemical product trading platform, consult suppliers, or refer to the chemical market survey report to get a timely and accurate price range.