Ethyl 5 Chloro 1h Pyrrolo 2 3 C Pyridine 2 Carboxylate
pyridine pyrrole pyrazine piperidine piperazine

ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate

    Specifications

    HS Code

    556372

    Chemical Formula C10H9ClN2O2
    Molar Mass 224.64 g/mol
    Appearance Typically a solid, color may vary (often white to off - white)
    Melting Point Specific value would require experimental determination, but common pyrrole - based esters may have melting points in the range of 100 - 200°C approximately
    Boiling Point Would likely decompose before boiling due to its heterocyclic and ester nature, but if stable, could be in a high - temperature range, e.g., >250°C
    Solubility In Water Low solubility in water as it is an organic compound with non - polar heterocyclic and ester groups
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, ethyl acetate, due to its organic nature
    Density Estimated density around 1.3 - 1.5 g/cm³ based on similar heterocyclic esters
    Pka The pyrrolo - pyridine nitrogen could have a pKa value in the range of 5 - 10, affecting its acid - base behavior
    Reactivity Reactive towards nucleophiles at the ester carbonyl group and can participate in substitution reactions; the chloro group can also be subject to substitution reactions under appropriate conditions

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    What is the chemical structure of ethyl 5-chloro-1H-pyrrolo [2,3-c] pyridine-2-carboxylate
    This is called "ethyl 5-chloro-1H-pyrrolo [2,3-c] pyridine-2-carboxylate". According to the chemical naming convention, its chemical structure can be solved. "Ethyl" is a common hydrocarbon group in organic compounds. It is obtained by removing a hydrogen atom from ethane, and the structure is simply - C ² H. "5-chloro" refers to the substitution of a chlorine atom at a specific position (position 5). "1H-pyrrolo [2,3-c] pyridine" describes the structure of the parent nucleus, which is a nitrogen-containing heterocyclic ring. The pyrrole-pyridine structure is formed by the fusing of a pyrrole ring with a pyridine ring. "1H" indicates that there is a hydrogen atom at position 1 on the pyrrole ring, and "[2,3-c]" defines the fusing mode and positional relationship of the two rings. "2-carboxylate" means connecting the carboxylate group at position 2. Overall, the chemical structure of this compound is 1H-pyrrolo [2,3-c] pyridine as the parent nucleus, the position 5 is replaced by a chlorine atom, and the position 2 is connected to a carboxylate ethyl group. Its structural abbreviation can be roughly drawn as: the parent nucleus pyrrole-pyridine ring, the 5-position is connected to a chlorine atom, and the 2-position is connected - COOCH -2 CH. This structure may have important applications in the fields of organic synthesis and medicinal chemistry due to its specific heterocycles and substituents or its unique physical, chemical and biological activities.
    What are the main uses of ethyl 5-chloro-1H-pyrrolo [2,3-c] pyridine-2-carboxylate
    Ethyl 5-chloro-1H-pyrrolo [2,3-c] pyridine-2-carboxylate is an organic compound. It has a wide range of uses and is often a key synthetic intermediate in the field of medicinal chemistry. By means of exquisite organic synthesis, it can be ingeniously converted into complex compounds with biological activities, or directly used to create new drugs, which is expected to play a key role in the treatment of diseases, such as in the development of anti-tumor and antibacterial drugs.
    In the field of materials science, it may be involved in the construction of organic materials with specific functions. Due to the unique molecular structure and electronic properties of the compound, it may endow the material with novel photoelectric properties, such as for the preparation of organic Light Emitting Diode (OLED) materials to improve luminous efficiency and stability; or for the preparation of organic semiconductor materials, it can be used in the field of organic electronic devices.
    In addition, in the field of pesticide chemistry, using this as a starting material, through a series of chemical reactions, efficient and environmentally friendly pesticides may be prepared. With its special affinity for certain biological activity check points, it is expected to develop special pesticides for specific pests or weeds, which can protect agricultural production while reducing adverse effects on the environment. In conclusion, ethyl 5-chloro-1H-pyrrolo [2,3-c] pyridine-2-carboxylate has potential and critical application value in many important fields, and is an important substance that cannot be ignored in the fields of organic synthesis and materials research.
    What are the synthesis methods of ethyl 5-chloro-1H-pyrrolo [2,3-c] pyridine-2-carboxylate
    The method of synthesizing ethyl 5-chloro-1H-pyrrolo [2,3-c] pyridine-2-carboxylate is an important problem in organic synthesis. There are many methods, and the common ones are as follows.
    First, a compound containing pyridine and pyrrole structures is used as the starting material. After halogenation, chlorine atoms are introduced at a specific position. If a suitable pyridine pyrrole derivative is selected, under suitable reaction conditions, a halogenating agent, such as a chlorine-containing halogenating agent, is used in a controlled temperature and solvent environment to precisely replace the hydrogen atoms at the target position, thereby obtaining a chlorine-containing intermediate. < Br >
    Second, on the basis of chlorine-containing intermediates, the structure of carboxylethyl esters is constructed. It can be achieved by nucleophilic substitution reaction. The chlorine-containing intermediate and the carboxylethyl ester-containing reagent undergo nucleophilic substitution in an appropriate organic solvent under the catalysis of a base. The base can activate the reagent to promote the smooth progress of the reaction. After this step, the target product ethyl 5-chloro-1H-pyrrolo [2,3-c] pyridine-2-carboxylate can be obtained.
    Third, there is also a strategy of gradually constructing the target molecule through a multi-step reaction. The pyridine ring is first constructed, and then the pyrrole structure is introduced, and then the substitution of chlorine atoms and the formation of carboxyl ethyl esters are completed in sequence. This process requires precise control of the reaction conditions of each step, such as reaction temperature, reactant ratio, catalyst type, etc. Each step of the reaction needs to ensure high selectivity and yield in order to efficiently synthesize the target product. The key to
    synthesis lies in the fine regulation of the reaction conditions, so that each step of the reaction proceeds in the expected direction, reducing the occurrence of side reactions, and improving the purity and yield of the product.
    What are the physical properties of ethyl 5-chloro-1H-pyrrolo [2,3-c] pyridine-2-carboxylate
    Ethyl-5-chloro-1H-pyrrolido [2,3-c] pyridine-2-carboxylic acid ester, this is an organic compound. Its physical properties are quite important, and it is of great significance in the fields of chemical and pharmaceutical research.
    First, the appearance is mentioned. Under normal temperature and pressure, it is mostly in the state of white to light yellow crystalline powder. This color state is conducive to preliminary identification and distinction. Looking at its color, its purity and impurity status can be inferred to a certain extent. If the color is abnormal or contains more impurities, it will affect subsequent application.
    The melting point is experimentally determined to be about a specific temperature range. This value is extremely critical for its identification and purity evaluation. The melting points of different purity substances are different. If the actual melting point deviates too much from the theoretical value, it will affect its quality and application. For example, in pharmaceuticals, the melting point does not meet the requirements, or the drug will have problems in dissolution and absorption in the body.
    In terms of boiling point, under specific pressure, it has a corresponding boiling point. This property is related to its behavior in the process of separation and purification. During distillation separation, it is separated from other substances according to the difference in boiling point to obtain high-purity products.
    Solubility is also the key. In common organic solvents such as ethanol and dichloromethane, it has a certain solubility, but it has poor solubility in water. This property determines its applicability in different reaction systems. In organic synthesis, choose the appropriate solvent according to the solubility to make the reaction proceed smoothly.
    Density cannot be ignored either. Under specific conditions, there is a definite density value. In storage, transportation and production, density affects packaging, metering and other operations.
    The physical properties of ethyl-5-chloro-1H-pyrrolido [2,3-c] pyridine-2-carboxylate play an important role in scientific research and production. In-depth understanding and precise control can make it effective in various fields.
    What is the market outlook for ethyl 5-chloro-1H-pyrrolo [2,3-c] pyridine-2-carboxylate
    Today, there is a product called ethyl + 5 - chloro - 1H - pyrrolo [2,3 - c] pyridine - 2 - carboxylate. To know its market prospects, this is a compound involved in the field of fine chemicals. In the past, organic synthesis technology was not as sophisticated as it is today. The preparation of such compounds was quite difficult and the cost remained high, so the market circulation was scarce. It only existed in the experimental scope of some scientific research institutions and was used for cutting-edge exploration. It has not yet been widely involved in the market.
    At present, with the development of science and technology, the maturity of organic synthesis technology, and the emergence of efficient catalysts and precise synthesis paths, the preparation cost of this product has dropped sharply, paving the way for it to enter the market. In the field of pharmaceutical research and development, many studies have shown that the structural properties of this product may become a key building block for new drugs, showing potential activity in specific disease targets. Such prospects have attracted the attention of many pharmaceutical companies, and they have deployed relevant research, hoping to develop innovative drugs based on this, and seize market opportunities.
    Furthermore, the field of materials science has also paid attention to it. Because of its unique structure, it may give materials other properties, such as the optimization of photoelectric properties. With the booming of electronic equipment and new energy industries, the demand for special performance materials is increasing day by day. This product may be able to take advantage of this to find a place in the materials market.
    However, its entry into the market also poses challenges. At the regulatory level, strict standards and complicated approval processes require time-consuming and labor-intensive responses to meet compliance requirements. In terms of market competition, similar or alternative compounds have already occupied a part of the market. To stand out, it is necessary to highlight their own advantages and make efforts in performance, cost and other dimensions.
    Overall, ethyl + 5 - chloro - 1H - pyrrolo [2,3 - c] pyridine - 2 - carboxylate Although the market prospect is challenging, the potential demand in the field of medicine and materials makes it have great potential for development. Over time, it may bloom in the market.