Ethyl 5-bromo-2-pyridinecarboxylate

Ethyl 5-bromo-2-pyridinecarboxylate, ethyl 5-bromo-2-pyridinecarboxylate, is an important chemical in organic synthesis.
This compound has many significant chemical properties. From its structural point of view, the pyridine ring is connected to the ester group and the bromine atom, giving it unique reactivity. Its ester group can undergo many classical reactions, such as hydrolysis. Under acidic or basic conditions, the ester group can be hydrolyzed. In acidic hydrolysis, under dilute acid and heating conditions, the ester group of ethyl 5-bromo-2-pyridinecarboxylic acid is gradually broken to form 5-bromo-2-pyridinecarboxylic acid and ethanol. In alkaline hydrolysis, strong alkali solutions such as sodium hydroxide or potassium hydroxide are commonly used, and the reaction is more rapid and thorough to generate 5-bromo-2-pyridinecarboxylic acid and ethanol. 5-bromo-2-pyridinecarboxylic acid can be obtained by subsequent acidification treatment.
Furthermore, its bromine atom is also active and reactive. It can participate in nucleophilic substitution reactions. If it encounters nucleophilic reagents, such as sodium alcohol and amines, bromine atoms can be replaced by corresponding nucleophilic groups. Taking sodium alcohol as an example, under the catalysis of appropriate solvents and bases, bromine atoms can be replaced by alkoxy groups to form new ether-containing bond compounds. This reaction is commonly used in the construction of complex organic molecular structures. At the same time, bromine atoms can also participate in metal-catalyzed coupling reactions, such as the Suzuki coupling reaction catalyzed by palladium, and the carbon-carbon bond can be formed with aryl boric acid under the action of palladium catalyst and base, which greatly enriches its derivatization pathway and is widely used in drug synthesis, material chemistry and other fields.
In addition, the pyridine ring itself also has special properties. The pyridine ring has a certain alkalinity and can react with acids to form salts, which is of great significance in separation and purification and the control of certain reaction conditions. At the same time, the electron cloud distribution characteristics on the pyridine ring make it have specific regioselectivity when electrophilic substitution occurs. Although the reactivity is slightly lower than that of the benzene ring, under suitable conditions and catalysts, other functional groups can still be introduced at specific positions in the pyridine ring to further expand its chemical properties and application scope.

Ethyl-5-bromo-2-pyridyl carboxylic acid ester, which has a wide range of uses. In the field of pharmaceutical synthesis, it is often used as a key intermediate for the preparation of various biologically active drugs. For example, when synthesizing specific antimalarial drugs, its structure can be chemically modified to precisely combine the drug with the malaria parasite target and enhance the efficacy. In the creation of pesticides, a variety of insecticides and fungicides can be derived from this as a starting material. Due to the existence of pyridine rings and ester groups, the compounds are endowed with unique chemical activity and stability, which can effectively resist pest infestation and protect crops. In the field of materials science, through specific chemical reactions, it can be introduced into the structure of polymer materials to improve the properties of materials such as thermal stability and optical properties, providing a way for the research and development of new functional materials. For example, the preparation of polymers with special photoluminescence properties can be used in the field of optoelectronics.

The method of synthesizing ethyl 5-bromo-2-pyridinecarboxylate can be started from 2-pyridinecarboxylic acid. First, the esterification reaction of 2-pyridinecarboxylic acid and ethanol under the catalysis of concentrated sulfuric acid is a common esterification step. At a suitable temperature, it is generally heated and refluxed to fully react the carboxylic acid with the alcohol to form the corresponding ester, that is, ethyl 2-pyridinecarboxylate.
Then, the bromination reaction of ethyl 2-pyridinecarboxylate is carried out. Liquid bromine can be selected as the bromination reagent and carried out in a suitable reaction environment in the presence of a suitable catalyst, such as iron powder or iron tribromide. The catalyst can promote the polarization of bromine molecules and enhance their reactivity. During the reaction process, attention should be paid to temperature control, not too high, to prevent excessive bromination. Under this condition, bromine atoms will selectively replace hydrogen atoms at specific positions on the pyridine ring, and finally form ethyl 5-bromo-2-pyridinecarboxylate. This synthesis route is clear and the conditions are easy to control, which is actually a common method for preparing this compound.

What you are inquiring about is the market price of ethyl-5-bromo-2-pyridyl carboxylate. However, in the market, prices often change for many reasons, such as origin, quality, supply and demand, and the time and quantity of transactions, all of which can make their prices different.
In the past, if the supply of this product exceeds demand, the price may decline; if there is a lot of demand and less supply, the price may rise. And in different places, the price is also different. In busy commercial ports, due to frequent transactions and convenient logistics, there may be a price advantage; in remote places, due to the difficulty of transshipment, the price may be slightly higher. < Br >
The difference in quality is also a variable in price. The price of refined high-quality products must be higher than that of ordinary products. If you want to find an accurate price, you should go to the chemical raw material market in person, or consult the merchants specializing in this industry, or visit the chemical trading platform to get the exact price at the moment. From my perspective, it is difficult to say the price of the fixed number.

Ethyl + 5 - bromo - 2 - pyridinecarboxylate is 5 - bromo - 2 - ethyl pyridinecarboxylate. When storing and transporting this substance, many matters need to be paid attention to.
First, the temperature and humidity of storage must be appropriate. This compound is more sensitive to changes in temperature and humidity. High temperature or high humidity environments may cause its chemical properties to change and even deteriorate. Therefore, when stored in a cool, dry place, the temperature should be controlled between 15 ° C and 25 ° C, and the relative humidity should be maintained at 40% to 60%.
Second, attention should be paid to isolating air and moisture. Ethyl 5-bromo-2-pyridinecarboxylate easily reacts with oxygen and moisture in the air. When storing, use a well-sealed container, such as a glass bottle or a plastic container with a sealing gasket, to prevent air and moisture from invading.
Third, during transportation, it is essential to prevent shock and collision. Because it is a chemical product, if it is subjected to violent vibration or collision, the container is easily damaged, resulting in leakage of items, which will not only cause losses, but also may cause safety accidents. Therefore, it is necessary to properly fix and add cushioning materials during transportation.
Fourth, avoid contact with incompatible objects. Ethyl 5-bromo-2-pyridinecarboxylate should not be stored or transported together with strong oxidants, strong bases and other substances, otherwise it is easy to cause chemical reactions and cause danger. Before storage and transportation, be sure to clarify its chemical properties and avoid contact with contraindicated substances.
Fifth, safety labels and documentation are indispensable. Storage and transportation containers should be clearly marked with their names, hazards and other information. At the same time, detailed records of storage conditions, transportation routes, quantities and other information can be traced and managed to ensure the safety of the whole process.