ethyl 5-bromo-2-methylpyridine-3-carboxylate

Ethyl-5-bromo-2-methylpyridine-3-carboxylic acid ester has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate to assist in the synthesis of various biologically active compounds.
First, it can be used to create new antibacterial drugs. Due to the structure of pyridine and carboxylic acid esters, it endows the molecule with unique chemical activity and stability, and can be cleverly modified to significantly enhance antibacterial activity. By carefully designing chemical reactions, specific functional groups can be added to target specific metabolic pathways or key proteins of bacteria, blocking bacterial growth and reproduction, and achieving antibacterial purposes.
Second, in drug development, it is used as a cornerstone for building complex drug molecules. Drug candidates with complex structures and specific pharmacological activities are precisely spliced with other organic fragments through a series of organic reactions, such as coupling reactions, nucleophilic substitution reactions, etc. Chemists use this to explore new chemical spaces, screen compounds with good drug potential, and bring new opportunities for new drug development.
Third, in the field of materials science, ethyl-5-bromo-2-methylpyridine-3-carboxylic acid esters are also useful. Functional materials with special optical, electrical or mechanical properties can be prepared through specific polymerization reactions. Its unique structure or the material exhibits fluorescence characteristics, used in the preparation of luminescent materials, used in display technology, sensors and other fields; or to improve the electrical properties of materials, used in organic electronic devices.
Fourth, in the field of agricultural chemistry, the compound can be used as an important raw material for the synthesis of new pesticides. Through reasonable structural modification, pesticides with high efficiency, low toxicity and environmental friendliness can be developed for the control of crop diseases and pests, and improve crop yield and quality.

There are several common methods for synthesizing ethyl 5-bromo-2-methylpyridine-3-carboxylate (ethyl 5-bromo-2-methylpyridine-3-formate).
First, it can be started from a suitable pyridine derivative. If 2-methylpyridine-3-formic acid is used as a raw material, it is first converted into the corresponding acid chloride, and thionyl chloride is often used to react with it. This is because when thionyl chloride reacts with carboxylic acid, the generated sulfur dioxide and hydrogen chloride are both gases, which are easy to separate, so that pyridine-3-formyl chloride is obtained. Subsequently, the acid chloride is reacted with ethanol in the presence of a base (such as pyridine), which can neutralize the hydrogen chloride generated by the reaction and promote the forward reaction to obtain ethyl 2-methylpyridine-3-carboxylate. Finally, the ester is brominated, and N-bromosuccinimide (NBS) can be selected as a bromination reagent. In the presence of an initiator (such as benzoyl peroxide) and under lighting conditions, in a suitable solvent (such as carbon tetrachloride), NBS can selectively introduce bromine atoms at the 5-position of the pyridine ring, resulting in ethyl 5-bromo-2-methylpyridine-3-carboxylate.
Second, take 2-methyl-5-nitropyridine-3-carboxylate as the starting material. First, the nitro group is converted into an amino group through a reduction reaction. The commonly used reducing agents are iron and hydrochloric acid, tin and hydrochloric acid, etc. The nitro group can be reduced to an amino group to obtain 2-methyl-5-aminopyridine-3-carboxylate. Next, the amino group is converted into a diazonium salt by diazotization reaction, and the reaction of sodium nitrite and hydrochloric acid is achieved at low temperature. The diazonium salt is unstable, and then reacts with cuprous bromide and hydrobromic acid, and a Sandmeyer reaction occurs. The diazonium group is replaced by a bromine atom, and the target product ethyl 5-bromo-2-methylpyridine-3-carboxylate is obtained.
The above methods have their own advantages and disadvantages. They need to be selected according to the actual situation, such as the availability of raw materials, cost, and difficulty of reaction conditions, in order to achieve the purpose of efficient synthesis.

Ethyl 5 - bromo - 2 - methylpyridine - 3 - carboxylate is an organic compound, and its physical properties are considerable.
This compound is in the form of a solid or liquid state, depending on the surrounding temperature and pressure. Under normal conditions, it is mostly seen in the liquid state. Looking at its color, it is usually colorless or slightly colored, just like clear water or slightly colored. Its appearance is clear, and it can be seen that the light is transparent.
When it comes to smell, it often emits a unique smell. This smell is not pungent or intolerable, but it also has a distinct personality, which can be recognized by those with a keen sense of smell. Its density is different from that of water. Compared with water, it may sink or float, depending on its density value. The boiling point and melting point of ethyl 5-bromo-2-methylpyridine-3-carboxylate are also important physical properties. The boiling point characterizes the temperature required for its transformation from a liquid state to a gaseous state, while the melting point is the critical temperature for its transformation from a liquid state to a liquid state. These two values vary depending on the intermolecular forces and structural characteristics. The boiling point and melting point of Ethyl 5-bromo-2-methylpyridine-3-carboxylate can be precisely determined by experiments to show its state changes at different temperatures.
The solubility cannot be ignored either. In organic solvents, such as ethanol and ether, it may have good solubility, just as salt dissolves naturally in water. In water, the solubility may vary, be slightly soluble, or insoluble, which is closely related to the polarity of the compound and the interaction between water molecules and compound molecules.
In addition, the volatility of Ethyl 5-bromo-2-methylpyridine-3-carboxylate is also a characteristic. At a specific temperature and environment, its molecules may escape into the air, resulting in a gradual change in concentration in the surrounding environment. This volatility needs to be considered in practical application and storage.

Looking at this question, I am inquiring about the market price of ethyl + 5 - bromo - 2 - methylpyridine - 3 - carboxylate. The name of this compound is ethyl 5 - bromo - 2 - methylpyridine - 3 - carboxylate. However, its market price is difficult to hide.
The price of the compound is affected by various factors. First, the cost of raw materials. If the raw materials required for the preparation of this compound are scarce, or the process of obtaining and purifying it is complicated, the cost of raw materials will be high, and the price of this compound will rise. Second, the synthesis is difficult. If there are many synthesis steps, severe reaction conditions are required, or special catalysts are used, the synthesis difficulty will increase greatly, the cost will also rise, and the price will rise. Third, the supply and demand of the market. If the market demand for this compound is strong, but the supply is limited, the price will rise; conversely, if the supply exceeds the demand, the price may drop.
Looking at the past "Tiangong Kaiwu", the price of all kinds of things changes over time and varies from situation to situation. The same is true for this compound. In different time and space and market environments, its price varies greatly. In the chemical raw material market, common suppliers price according to the quantity, and if the quantity is large, the price may be preferential. And different regions, due to different transportation costs and tax policies, prices also vary. Or in prosperous industrial places, the price is slightly lower due to convenient supply; and in remote places, the price may be higher due to high logistics costs. Therefore, to know the exact market price, it is necessary to carefully check the quotation of the chemical raw material trading platform, or consult the relevant suppliers to obtain a more accurate figure.

ethyl+5-bromo-2-methylpyridine-3-carboxylate is an organic compound, the Chinese name may be 5-bromo-2-methylpyridine-3-carboxylate ethyl ester. During storage and transportation, many matters need to be paid attention to.
First of all, this compound is sensitive to light and air. Therefore, it should be stored in a shaded and sealed container to avoid light and air oxidation. And it should be placed in a cool, dry place, away from fire and heat sources. If the temperature is too high, it may cause chemical reactions and cause quality changes. The warehouse should be well ventilated to prevent the accumulation of harmful gases. If stored in a humid environment, it may react with water, affecting the purity and properties.
As for transportation, it is necessary to ensure that the packaging is intact. Packaging materials should be able to withstand certain external forces to prevent collisions and drops from causing package ruptures and material leakage. During transportation, high temperatures and open flames should also be avoided. Because of its flammability or other dangerous characteristics, high temperatures, open flames or cause safety accidents. Transportation vehicles need to be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment. In case of leakage, they can respond in time. And transportation personnel should be professionally trained and familiar with the properties of the compound and emergency treatment methods.
When storing and transporting ethyl+5-bromo-2-methylpyridine-3-carboxylate, be careful and follow relevant safety regulations to ensure personnel safety and material quality.