ethyl 5-aminopyrazolo[1,5-a]pyridine-3-carboxylate

Ethyl 5-aminopyrazolo [1,5-a] pyridine-3-carboxylate is an organic compound with a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate. This compound has a unique structure and contains nitrogen heterocycles, which have a significant impact on biological activity. Through its chemical modification and derivatization, a variety of biologically active compounds can be synthesized, such as antibacterial, antiviral, and anti-tumor drugs. Because of its structure, it can fit specific targets in organisms and play corresponding pharmacological effects.
In the field of materials science, ethyl 5-aminopyrazolo [1,5-a] pyridine-3-carboxylate is also used. Due to the specific electronic structure and chemical properties of this compound, it can participate in the preparation of materials with special optical and electrical properties. For example, it is used to prepare organic Light Emitting Diode (OLED) materials, which endow the materials with unique luminous properties and improve the luminous efficiency and color purity of OLED devices.
Furthermore, in agricultural chemistry, it can be used to develop new pesticides. Because of its specific biological activity against certain pests or pathogens, it can be designed and optimized by rational molecules to develop high-efficiency, low-toxicity, and environmentally friendly pesticides, which can help control crop diseases and pests and improve agricultural production efficiency. In conclusion, ethyl 5-aminopyrazolo [1,5-a] pyridine-3-carboxylate has important uses in many fields such as medicine, materials, and agriculture, providing a key chemical basis for the development of various fields.

To prepare ethyl 5 - aminopyrazolo [1,5 - a] pyridine - 3 - carboxylate, there are various methods. Nitrogen-containing heterocyclic compounds are often used as starting materials, and a series of organic reactions are used to achieve it.
First take an appropriate pyridine derivative, and under specific reaction conditions, carry out a condensation reaction with a nitrogen-containing reagent. This condensation reaction requires precise regulation of the reaction temperature, time and the proportion of reactants. If the cap temperature is too high or the time is too long, it may cause a cluster of side reactions, which will affect the purity and yield of the product. Usually, the reaction temperature should be controlled in a mild range, about ten degrees Celsius, and the duration depends on the specific reaction process, or several hours or even ten hours.
After condensation, the product needs to be separated and purified. Commonly used methods, such as column chromatography, use silica gel as the stationary phase, select an appropriate eluent, and separate the target product from the impurity by the difference in the distribution coefficient between the stationary phase and the mobile phase of different substances.
There are also those who use pyrazole compounds as starting materials. The pyrazole reacts with the reagent containing the pyridine structure in the presence of a catalyst. The catalyst used, either a metal salt or an organic base, can reduce the activation energy of the reaction and promote the progress of the reaction. The reaction system needs to be maintained in a dry and oxygen-free environment, and the product is impure due to water and oxygen or interference with the reaction process. < Br >
After the reaction is completed, it also needs to go through the separation and purification process. The method of recrystallization can be used, a suitable solvent is selected, the product is heated to dissolve, and then slowly cooled to allow the product to crystallize and precipitate, and then pure ethyl 5-aminopyrazolo [1,5-a] pyridine-3-carboxylate is obtained. The whole synthesis process requires fine operation at each step and the reaction conditions are observed to obtain the desired result.

Ethyl-5-aminopyrazolo [1,5-a] pyridine-3-carboxylic acid ester is a kind of organic compound. Its physical and chemical properties are quite important and are related to the various applications of this compound.
In terms of its physical properties, ethyl-5-aminopyrazolo [1,5-a] pyridine-3-carboxylic acid esters are mostly solid at room temperature, but their exact physical forms may vary depending on purity and preparation methods. The determination of its melting point can be one of the key indicators for the identification of this compound. After many experimental investigations, it can be seen that its melting point is within a certain temperature range, which varies slightly due to subtle differences in experimental conditions.
As for solubility, this compound exhibits specific solubility properties in common organic solvents. In polar organic solvents, such as ethanol, dichloromethane, etc., its solubility is relatively high, which is due to the interaction between the molecular structure and the solvent molecules. In water, its solubility is low, due to the large proportion of hydrophobic molecules.
In terms of chemical properties, the amino and ester groups of ethyl-5-aminopyrazolo [1,5-a] pyridine-3-carboxylic acid esters endow them with rich chemical reactivity. Amino groups are nucleophilic and can participate in many nucleophilic substitution reactions, such as reactions with acyl halides, halogenated hydrocarbons, etc., to form new chemical bonds and expand the structure of molecules. Ester groups can undergo hydrolysis under acid or base catalysis conditions. The rate and extent of this hydrolysis reaction are significantly affected by factors such as reaction temperature and catalyst concentration. In addition, the heterocyclic structure of pyrazolopyridine also enables it to participate in the aromatic electrophilic substitution reaction. Under specific conditions, various substituents are introduced to prepare derivatives with different functions. The chemical properties of this compound provide many possibilities for the field of organic synthesis, and have potential applications in medicinal chemistry, materials science, etc.

I have not heard of the exact price of ethyl-5-aminopyrazolo [1,5-a] pyridine-3-carboxylate in the market. This compound may be rare, or due to difficult preparation and poor demand, there is little information in the market. To know its price, you can explore it from several ways.
First, ask chemical raw material suppliers. Many companies specializing in fine chemicals often store various special compounds. You can write or call to ask if they have this product and what the price is. However, the pricing of each merchant may vary depending on the purity, packaging, and purchase quantity. You need to consult several times to get a good price.
Second, explore the chemical product trading platform. Such as Gade Chemical Network, etc., where merchants gather to list the prices of various chemicals. Although it may not be possible to directly obtain the price of ethyl-5-aminopyrazolo [1,5-a] pyridine-3-carboxylate, it may be based on the price of similar structural compounds. And the platform can often consult merchants to obtain quotations.
Third, refer to academic literature and research reports. Although some scientific research materials or the preparation cost of this material are not directly sold, the approximate cost can also be deduced according to the raw materials and process complexity required for preparation to help estimate its market price.
I don't have an exact price range to provide. If you follow the above methods, you can get a more accurate price.

There are many derivatives related to ethyl-5-aminopyrazolo [1,5-a] pyridine-3-carboxylic acid esters. This compound has a unique structure and rich and diverse derivation methods.
As far as the modification of amino groups is concerned, the hydrogen atom on the amino group can be replaced by various alkyl and aryl substituents through nucleophilic substitution reactions, resulting in a series of amino-substituted derivatives. These reactions often require a suitable base as a catalyst and are carried out in a specific temperature and solvent environment.
For pyridine and pyrazole rings, due to their aromaticity and unsaturation, electrophilic substitution reactions can be carried out. For example, halogenation reactions can introduce halogen atoms into the ring; nitration reactions can introduce nitro groups, and subsequent reduction of nitro groups to amino groups can further expand the derivation path.
And carboxylic acid ester groups are chemically active. It can be converted into carboxylic acids by hydrolysis, and the carboxylic acids are esterified with alcohols, and derivatives of different ester groups can be formed. In addition, carboxylic acids can also react with amines to form amides. This process often requires the assistance of condensers to promote the smooth progress of the reaction.
Furthermore, based on this compound, through the formation of carbon-carbon bonds, such as Suzuki coupling reaction, Heck reaction, etc., different aryl groups or alkenyl groups can be connected, greatly enriching the structure types of its derivatives, providing a broad space for the creation of compounds with unique properties and biological activities.