ethyl 4-chloropyridine-2-carboxylate

Ethyl 4-chloropyridine-2-carboxylic acid ester is an important compound in the field of organic chemistry. It has specific physical properties and is often used as a key intermediate in many organic synthesis reactions.
Looking at its appearance, under room temperature and pressure, it is mostly colorless to light yellow liquid, with clear texture or crystalline solid, depending on the specific purity and environmental conditions. Its melting point is about [X] ° C, and its boiling point is in the range of [X] ° C. Such melting boiling point characteristics are of great significance in the separation and purification process of compounds.
When it comes to solubility, ethyl 4-chloropyridine-2-carboxylate is soluble in many organic solvents, such as common ethanol, ether, dichloromethane, etc., but it is difficult to dissolve in water. This difference in solubility provides convenience for its participation in various reactions in organic synthesis and its separation and extraction from the reaction system.
The density of this compound is about [X] g/cm ³, which is slightly heavier than water. Its vapor pressure is relatively low at room temperature and its volatility is weak. And it has certain stability. However, under certain conditions, such as high temperature, strong acid, and strong alkali environment, chemical reactions will also occur, causing its structure to change. The physical properties of ethyl 4-chloropyridine-2-carboxylate make it widely used in organic synthesis, medicinal chemistry, and other fields. With its solubility and stability, researchers can convert it into various more valuable compounds under specific reaction conditions, thus providing assistance for the development of new drug research and materials science.

The chemical synthesis methods of ethyl 4-chloropyridine-2-carboxylic acid esters have existed in ancient times, and with the evolution of the times, the methods have become more and more abundant. The following are common types:
First, pyridine-2-carboxylic acid is used as the starting material. First, pyridine-2-carboxylic acid and ethanol are esterified under the action of concentrated sulfuric acid and other catalysts to form ethylpyridine-2-carboxylic acid esters. This reaction requires heating and refluxing to fully react the carboxylic acid with the alcohol to achieve the purpose of esterification. Then, the obtained ethylpyridine-2-carboxylic acid ester is chlorinated by chlorination reagents such as thionyl chloride and phosphorus oxychloride. When thionyl chloride participates in the reaction, it reacts with the substrate at an appropriate temperature, and the thionyl group replaces the hydroxyl group to form the corresponding chlorination product, that is, ethyl 4-chloropyridine-2-carboxylic acid ester. This process requires attention to the reaction temperature and the amount of reagents to prevent excessive chlorination or side reactions.
Second, 4-chloropyridine-2-carboxylic acid is used as the starting material. It is directly esterified with ethanol under acid catalysis. This acid catalyst can be selected as p-toluenesulfonic acid. P-toluenesulfonic acid can effectively promote the esterification reaction, and the reaction system is gradually converted into esters by acid and alcohol under heating conditions. This method is relatively direct and avoids the complicated steps that may be caused by esterification first and then chlorination, but it has certain requirements for the purity and acquisition of the starting material 4-chloropyridine-2-formic acid.
Third, through the construction and modification of the pyridine ring. With suitable nitrogen-containing and carbon-containing raw materials, such as 2-amino-3-chloropyridine and diethyl malonate, under the catalysis of base, the pyridine ring is formed by cyclization reaction, and ethyl ester is introduced at the same time. Sodium ethyl alcohol can be used as a base to activate the raw material molecules and promote the reaction. The resulting pyridine ring products may need to be further modified and purified to obtain the target product ethyl 4-chloropyridine-2-carboxylate. Although this method is slightly complicated, it may have unique advantages for specific raw material sources and reaction conditions.
The above synthesis methods have their own advantages. In practical application, the choice needs to be weighed according to factors such as raw material availability, cost, reaction conditions and product purity requirements.

Ethyl-4-chloropyridine-2-carboxylic acid ester, which is useful in many fields. In the field of medicinal chemistry, it is often a key synthetic block. The structure of the Geyne pyridine ring is stable and has unique electronic properties. The substitution of 4-chlorine atom and carboxyl ethyl ester endows it with various reactivity. In this way, complex and biologically active molecular structures can be constructed through various chemical reactions, such as nucleophilic substitution, coupling reactions, etc., which are mostly used to create antibacterial, anti-inflammatory, anti-tumor and other drugs.
In the field of pesticide chemistry, it has also emerged. Pesticides made from it have high-efficiency inhibition and killing effects on pests. Or by interfering with the physiological functions of the nervous system and respiratory system of pests, the purpose of controlling pests can be achieved, and the agricultural harvest can be escorted.
In the field of materials science, ethyl-4-chloropyridine-2-carboxylic acid esters also have their uses. It can participate in polymerization reactions to prepare functional polymer materials. The resulting materials may have special optical, electrical and thermal properties, and show application potential in optoelectronic devices, sensors, etc. For example, the prepared polymer materials may have sensitive responses to specific substances and be used as sensors to detect environmental pollutants, biomarkers, etc.
In summary, ethyl-4-chloropyridine-2-carboxylate is indispensable in many fields such as medicine, pesticides, and materials science, and has made significant contributions to the development of various fields.

Wen Jun inquired about the market price of ethyl 4 - chloropyridine - 2 - carboxylate, which is a chemical substance. The market value depends on many factors, which is difficult to hide.
First, the difficulty of obtaining raw materials is related to its price. If raw materials such as 4 - chloropyridine - 2 - carboxylic acid and ethanol are easily available, and the supply is sufficient, the cost can be reduced, and the market price may also be close to the people; on the contrary, if raw materials are scarce, difficult to find, and the cost increases greatly, the price will also be high.
Second, the complexity of the preparation process has a great impact. If the process of preparing this compound is simple and efficient, with low energy consumption and high yield, the cost is controllable, and the market price may drop; if the process is complicated, special equipment and harsh conditions are required, and the investment of manpower and material resources is huge, the price will be high.
Third, the market supply and demand situation determines the price. If the market demand for this compound is strong, but the supply is limited, the merchant may raise the price to obtain more profits; if the demand is weak and the supply is excessive, the merchant will de-stock or reduce the price for promotion.
Fourth, the manufacturer's brand and product quality also play a role. Well-known manufacturers pay attention to quality, production specifications, high product purity, low impurities, and the price may be higher than that of ordinary manufacturers.
Overall, the market price of ethyl 4 - chloropyridine - 2 - carboxylate is changing dynamically, ranging from a few yuan per gram to tens of yuan per gram or even higher, depending on the current market conditions, purchase volume and trading conditions.

Ethyl 4-chloropyridine-2-carboxylic acid ester is one of the organic compounds. The key to its storage is related to the quality and safety of this substance.
When stored, it is advisable to choose a cool and dry place. If it is in a warm and humid place, it may not cause chemical changes. Warm cover can promote its molecular activity to intensify, while wet or cause hydrolysis changes, damaging its structure and properties.
It is also necessary to avoid contact with fire sources and oxidants. This compound may be flammable, and it is dangerous to be exposed to fire, and the oxidant can promote its violent reaction, causing the risk of ignition and explosion.
It is also necessary to store it in a closed container. The first is to prevent it from volatilizing and escaping from the air, causing qualitative changes, and avoiding harm to the surrounding environment and people; the second is to block external water vapor, oxygen, etc. from connecting with it to ensure its chemical stability.
For the storage of this object, it is appropriate to use corrosion-resistant materials, such as glass, specific plastics, etc. Because of the metal device or reacting with it, the device can be etched and the quality of the compound can be changed.
In addition, the storage place should be clearly identified, marked with its name, sex, danger, etc., so that it can be taken and placed. In case of emergency, people can quickly dispose of it. < Br >
According to these rules, ethyl 4-chloropyridine-2-carboxylate should be stored carefully to ensure its quality and avoid the risk of accidents.