Ethyl 4-chloro-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-car

Ethyl 4-chloro-1,3 -dimethyl-1H -pyrazolo [3,4 -b] pyridine -5 -carboxylate (4 -chloro-1,3 -dimethyl-1H -pyrazolo [3,4 -b] pyridine-5 -carboxylate ethyl ester), this is an organic compound. Its chemical properties are unique and significant in the field of organic synthesis.
From a structural point of view, the compound contains a pyrazolo-pyridine parent nucleus, which gives it a specific chemical activity. Among them, the 4-position chlorine atom has high activity and can participate in nucleophilic substitution reactions. Due to the strong electronegativity of chlorine atoms, the carbon-chlorine bond electron cloud is biased towards the chlorine atom, making the carbon atom partially positively charged and vulnerable to nucleophilic reagents. For example, if there is a nucleophilic reagent such as sodium alcohol, the alkoxy negative ion will attack the 4-position carbon atom, and the chlorine atom will leave to form a new ether derivative. The methyl group at the
1,3 position also affects the properties of the compound. Methyl group is the power supply group, which can increase the electron cloud density of the pyrazole-pyridine ring, change its charge distribution, and affect the nucleophilic and electrophilic reactivity of the compound. For example, in the electrophilic substitution reaction of aromatic rings, the increase of electron cloud density will make the reaction more likely to occur, and the steric resistance effect of The carboxylic acid ethyl ester group at the
5 position is also critical. It can undergo hydrolysis reactions. Under acidic or basic conditions, the ester group can be hydrolyzed to carboxylic acids. Under alkaline conditions, such as sodium hydroxide solution, hydrolysis is more thorough, resulting in sodium carboxylate salts. After acidification, the corresponding carboxylic acid can be obtained. The carboxylic acid can be further esterified with alcohols or reacted with amines to form amides.
In addition, the pyridine nitrogen atom of the compound has a certain alkalinity, which can form salts with acids and change its physical and chemical properties, such as solubility. Due to these chemical properties, this compound may have potential applications in drug synthesis, materials science and other fields.

Ethyl 4-chloro-1,3 -dimethyl-1H -pyrazolo [3,4 -b] pyridine -5 -carboxylate, this is an organic compound, and its main uses are as follows:
First, in the field of pharmaceutical chemistry, it can be used as a key intermediate. Due to the specific chemical structure of this compound, it can participate in a series of chemical reactions to help build complex drug molecules. Taking the development of new antibacterial drugs as an example, with this intermediate, it can be linked to other active groups through specific reactions to create antibacterial agents with high inhibitory effect on specific pathogens. This is because the structure of pyrazolopyridine often exhibits unique biological activity in drug molecules, which is in line with specific targets in organisms, thereby regulating physiological processes and achieving the purpose of treating diseases.
Second, in the field of pesticide research and development, it is also an important raw material. With its structural properties, chemically modified and modified, pesticides with high insecticidal, bactericidal or herbicidal properties can be prepared. For example, by introducing specific substituents, the interaction between molecules and receptors or enzymes in target organisms is optimized, so that the synthesized pesticides have high selectivity and activity to specific pests or weeds, while reducing the impact on non-target organisms and improving the environmental friendliness of pesticides.
Third, in organic synthetic chemistry, as a basic module, it is used to synthesize more complex and diverse heterocyclic compounds. Organic chemists can use their unique reactivity and structure to carry out various cyclization, coupling and other reactions to construct heterocyclic systems with different functional groups and structures. This not only enriches the variety of organic compounds, but also lays the foundation for the research and development of new materials, the total synthesis of natural products and other fields, and promotes the development of organic chemistry.

The synthesis of ethyl 4-chloro-1,3-dimethyl-1H-pyrazolo [3,4-b] pyridine-5-carboxylate (4-chloro-1,3-dimethyl-1H-pyrazolo [3,4-b] ethyl pyridine-5-carboxylate) is a key exploration in the field of organic synthesis. To make this substance, the following ancient methods can be followed.
First, suitable starting materials, such as compounds containing pyridine structure and reagents containing pyridine structure, are blended under specific conditions. Choose an appropriate solvent, such as dichloromethane, N, N-dimethylformamide (DMF), etc., to disperse the raw materials uniformly and promote the reaction.
Then, add an appropriate amount of alkali, such as potassium carbonate, sodium carbonate, etc. The function of alkali is to adjust the pH of the reaction system and promote specific reactions of raw material molecules. Under heating conditions, the activity of molecules in the reaction system is enhanced, and the chemical bonds between the starting materials are broken and recombined.
During the reaction, the temperature and reaction time need to be carefully controlled. If the temperature is too high, or side reactions increase, the purity of the product decreases; if the temperature is too low, the reaction rate is delayed and takes a long time. Generally speaking, the temperature is controlled between 50-100 ° C, and the reaction time is about 6-12 hours.
After the reaction is completed, the reaction mixture is treated by conventional separation methods, such as extraction, column chromatography, etc. The product is first extracted with a suitable organic solvent, and then further purified by column chromatography. A suitable eluent is selected to separate impurities and obtain high purity Ethyl 4-chloro-1,3-dimethyl-1H-pyrazolo [3,4-b] pyridine-5-carboxylate.
However, this synthesis method may cause fluctuations in the yield and purity of the product due to the purity of the raw materials and the subtle differences in reaction conditions. In actual operation, it needs to be flexibly adjusted according to specific circumstances to achieve the best synthesis effect.

Ethyl 4-chloro-1,3-dimethyl-1H-pyrazolo [3,4-b] pyridine-5-carboxylate is a fine chemical product, and its market price range often fluctuates due to a variety of factors.
The preparation process of this compound is complicated, and the cost of raw materials, the number of synthesis steps and the difficulty have a great impact on its price. If the raw materials are rare and difficult to find, or the synthesis requires multiple complex reactions, the cost will be high, which will then push up the price.
Furthermore, the market supply and demand situation is also key. If there is a large increase in demand for this compound in the fields of medicine, pesticides, etc., and the supply is limited, the price will rise; conversely, if the market is saturated and the supply is sufficient, the price may stabilize or decline.
In addition, the scale of production also affects the price. In large-scale production, the unit cost may be reduced due to the scale effect, and the price will be more competitive; in small-scale production, the cost is relatively high, and the price may be high.
According to past market transaction information and industry trends, the price of Ethyl 4 - chloro - 1,3 - dimethyl - 1H - pyrazolo [3,4 - b] pyridine - 5 - carboxylate per gram ranges from tens to hundreds of yuan. However, this is only a rough range, and the actual price depends on factors such as quality, purity, transaction quantity and current market conditions at the time of specific transaction. When purchasing or selling this compound, it is recommended to consult multiple suppliers or buyers in detail to fully consider the above factors in order to obtain an accurate price.

Ethyl 4-chloro-1,3-dimethyl-1H-pyrazolo [3,4-b] pyridine-5-carboxylate is an organic compound. For its safety, the following numbers should be paid attention to:
First, this substance has potential chemical activity, and during operation, direct contact should be avoided. If you accidentally touch the skin, you need to rinse it with a lot of water immediately, and depending on whether the situation is serious or not, consider whether to seek medical attention. If you splash into the eyes, it will not be delayed for seconds. Be sure to rinse the eyes with flowing water or normal saline immediately, and then seek medical attention as soon as possible to avoid irreversible damage to the eyes.
Second, the smell may irritate the respiratory tract. Therefore, the operation should be carried out in a well-ventilated place, or even with the help of professional equipment such as fume hoods, to ensure that the concentration of the substance in the air is within a safe range, so as to effectively avoid respiratory discomfort such as cough and asthma after inhalation.
Third, under certain conditions, this compound may undergo chemical reactions. Therefore, when storing, it is necessary to keep away from fire sources, heat sources and various strong oxidants, reducing agents, etc. to prevent extreme dangerous conditions such as fire and explosion. The storage environment should also be kept dry and cool, so as to ensure its stability and reduce latent risk.
Fourth, the experiments carried out on Ethyl 4-chloro-1, 3-dimethyl-1H-pyrazolo [3,4-b] pyridine-5-carboxylate must be carried out in strict accordance with the established experimental procedures and safety operating guidelines. The experimenter himself needs to wear complete protective equipment, such as experimental clothes, gloves, protective glasses, etc., and take all-round protective measures to ensure his own safety to the greatest extent.
Only by paying high attention to the above safety precautions in many links such as operation and storage can effectively avoid possible dangers and ensure the safety of personnel and the smooth progress of the experiment.