ethyl 3-chloropyridine-4-carboxylate

Ethyl 3-chloropyridine-4-carboxylic acid esters are very important chemical substances in the field of organic synthesis. They have a wide range of uses, first in the field of medicinal chemistry. In this field, they are often used as key intermediates to prepare various biologically active pharmaceutical molecules. The structural properties of the pyridine ring and ester group endow them with unique chemical properties and spatial configuration, which is convenient for chemists to modify and derive them, so as to obtain compounds with specific pharmacological activities, such as the development of antibacterial, anti-inflammatory, anti-tumor and other drugs. Ethyl 3-chloropyridine-4-carboxylic acid esters may play an important role.
Secondly, in the field of materials science, it also has certain uses. Due to the chlorine atom, pyridine ring and ester group contained in its structure, it can participate in many chemical reactions to prepare polymer materials with special properties. For example, through polymerization with other monomers, polymer materials with specific optical, electrical or mechanical properties can be prepared, which can be used in optical devices, electronic components and other fields.
Furthermore, in the study of organic synthetic chemistry, ethyl 3-chloropyridine-4-carboxylic acid esters, as an important intermediate, can participate in a variety of organic reactions, such as nucleophilic substitution reactions, esterification reactions, condensation reactions, etc. By ingeniously designing reaction routes and using their structural characteristics, chemists can construct more complex organic molecular structures, expand the types and properties of organic compounds, and provide an important material basis and reaction pathway for the development of organic synthetic chemistry.

The synthesis of ethyl 3-chloropyridine-4-carboxylate (ethyl 3-chloropyridine-4-carboxylate) has been explored by many parties in the past, and there are many methods.
First, 3-chloropyridine-4-carboxylic acid is used as the starting material and ethanol is esterified under the catalysis of strong acids such as concentrated sulfuric acid. This reaction requires the two to be placed in a suitable reaction vessel and heated to reflux. Strong acid catalysis can promote the dehydration between carboxylic acid and alcohol to form esters. However, this process needs to pay attention to the control of reaction temperature. If it is too high, side reactions will occur, which will affect the purity and yield of the product. < Br >
Second, suitable pyridine derivatives can be introduced into the chlorine atom at the 3-position through halogenation reaction, followed by carboxylation reaction, and then esterified with ethanol. When halogenation, the choice of suitable halogenation reagents and reaction conditions is the key, and carboxylation also requires the selection of appropriate reagents and reaction paths to efficiently obtain the target product precursor, and then esterified to obtain ethyl 3-chloropyridine-4-carboxylate.
Third, a complex compound containing pyridine ring is used as the starting material, and the structure of 3-chloropyridine-4-carboxylate is gradually constructed through multi-step reaction. Although there are many steps in this path, if the design is exquisite, the target product can be obtained and the product structure can be fine-tuned.
There are various methods for synthesizing ethyl 3-chloropyridine-4-carboxylate, each with advantages and disadvantages. It is necessary to carefully choose the appropriate method according to the availability of raw materials, the difficulty of controlling the reaction conditions, and the cost to achieve the purpose of efficient synthesis.

Ethyl 3-chloropyridine-4-carboxylic acid ester, this substance is an organic compound. Looking at its structure, it is based on a pyridine ring, with a chlorine atom at the third position on the ring, and a carboxylic acid ethyl at the fourth position.
In terms of its physical properties, at room temperature, it may be a colorless to light yellow liquid with a specific odor. Because the structure contains polar groups, it is slightly soluble in water, but it can be miscible with common organic solvents such as ethanol, ether, chloroform, etc. This characteristic is derived from the principle of similarity and miscibility. Its boiling point and melting point are subject to intermolecular forces, and it contains polar bonds. The intermolecular forces are slightly stronger. The boiling point may be within a certain range, but the exact value needs to be determined experimentally.
As for the chemical properties, the pyridine ring is aromatic and can undergo electrophilic substitution reaction. The chlorine atom at the third position has high activity and can participate in nucleophilic substitution, such as reacting with nucleophilic reagents such as alcohols and amines, and being replaced by corresponding groups. The carboxylic acid ethyl ester group can be hydrolyzed. Under acidic or basic conditions, it can be hydrolyzed to obtain carboxylic acid and ethanol, or carboxylate and ethanol, respectively. It can also undergo ester exchange reaction with alcohol to adjust the ester structure. Under suitable catalytic conditions, it can also participate in the reduction reaction, so that the pyridine ring or ester group can be reduced. This compound has a wide range of uses in the field of organic synthesis and can be used as an intermediate to prepare key compounds in the fields of medicine, pesticides, and materials through series reactions.

I look at this "ethyl 3-chloropyridine-4-carboxylate", which is the chemical ethyl 3-chloropyridine-4-carboxylate. However, the price range on the market is difficult to say exactly. Because the price of chemical reagents often changes for a variety of reasons, such as quality grade, supply channels, market supply and demand.
In the past, when I looked at "Tiangong Kaiwu", it detailed all kinds of process products, but the price of such chemicals was not recorded in ancient times, so it is difficult to refer to. If you want to know the price range of this product today, you can explore it from several places. First, the websites of chemical reagent sellers, such as Sinopharm Group Chemical Reagent Network, etc., list the prices of many reagents, and you can check the price of this product under different specifications. Second, inquire from chemical-related enterprises and scientific research institutions. They often purchase this product and know the price.
Generally speaking, if it is an ordinary purity grade, small packaging (such as 5 grams, 10 grams), the price per gram may be in the tens of yuan. If it is high purity, used in fine chemical synthesis or pharmaceutical research and development, the price will rise sharply, or more than 100 yuan per gram, or even higher. If the purchase volume is large, such as the kilogram level, due to the scale effect, the unit price may decrease, or drop to tens of yuan per gram. However, this is a rough estimate, and the actual price still needs to be determined according to the actual market situation.

"Ethyl 3-chloropyridine-4-carboxylate", the Chinese name is ethyl 3-chloropyridine-4-carboxylate. This compound is widely used in chemical, pharmaceutical and other fields. This talk and its manufacturers are involved in many chemical companies.
In China, there are well-known chemical companies such as ** [company A name] **, whose craftsmanship is exquisite, and the 3-chloropyridine-4-carboxylate produced is of high quality. It is supplied to many domestic pharmaceutical companies and chemical manufacturers, and has a good reputation. There are also ** [company B name] **, and also focus on the production of this chemical. With innovative technology and efficient process, the products are not only sold well in China, but also exported overseas.
Overseas countries, such as Europe, America and other places, ** [company C name] ** Well-known, it has a long history in the manufacture of organic synthetic chemicals. The production scale of 3-chloropyridine-4-carboxylate ethyl ester is huge, and the quality control is extremely strict, which is trusted by many customers around the world. ** [company D name] ** It is also an important manufacturer. With advanced research and development and capacity, it continuously optimizes product performance and occupies a place in the international market.
All these manufacturers contribute to the production of ethyl 3-chloropyridine-4-carboxylate, promoting the application and development of this chemical in various fields.