ethyl 2-(trifluoromethyl)pyridine-3-carboxylate

Ethyl 2- (trifluoromethyl) pyridine-3-carboxylate, Chinese name 2- (trifluoromethyl) pyridine-3-carboxylate ethyl ester. The main use of this substance is often used in the field of synthesis.
It can be used as an important starting material or medium for synthesis. Because the molecule contains special functions such as pyridine and trifluoromethyl, ester group, etc., it has many properties. Pyridine has certain properties and coordination ability. Trifluoromethyl can increase the fat solubility, qualitative and biological activity of compounds, and ester groups have many properties.
For example, a carboxylic acid can be obtained from the hydrolysis reaction of an ester group; a carboxylic acid can be synthesized from derivatives such as acetyl chloride and amide in one step, and used in the synthesis of compounds, materials, etc. It can also utilize the active sites on the pyridine group, such as nuclear substitution, gold catalysis, etc., to improve the molecular properties of the compound. In the field of chemical research, trifluoromethyl can improve the physicalization and biological activity of the compound molecule, so ethyl 2- (trifluoromethyl) pyridine-3-carboxylate is often introduced into the compound molecule, in order to obtain new compounds with higher activity and better substitution properties. In the field of materials, fluorine-containing materials synthesized from this product may have special properties such as optical, optical, and qualitative properties, which can be used in the field of optical materials.

To prepare ethyl 2- (trifluoromethyl) pyridine - 3 - carboxylate, there are two common methods.
First, take 2- (trifluoromethyl) pyridine - 3 - carboxylic acid as the starting material, and carry out esterification reaction with ethanol under acid catalysis. Concentrated sulfuric acid or p-toluenesulfonic acid is often selected. This reaction needs to be heated and refluxed to promote the reaction to generate esters. The specific operation is: in the reaction bottle, add 2- (trifluoromethyl) pyridine - 3 - carboxylic acid, excess ethanol and an appropriate amount of catalyst, connect a reflux condenser, and control the appropriate temperature reaction on the heating device. After the reaction, the product is purified through neutralization, separation, distillation and other steps.
Second, use 2 - (trifluoromethyl) -3 - bromopyridine as raw material. First, magnesium chips are made into Grignard reagent in anhydrous ether, and then carbon dioxide is introduced to generate a magnesium salt of 2 - (trifluoromethyl) pyridine - 3 - carboxylic acid, and then acidified to obtain 2 - (trifluoromethyl) pyridine - 3 - carboxylic acid, followed by esterification with ethanol, as described above. Alternatively, 2 - (trifluoromethyl) -3 - bromopyridine with carbon monoxide and ethanol under the action of suitable catalysts (such as palladium catalysts) and bases, ethyl 2- (trifluoromethyl) pyridine - 3 - carboxylate is directly produced by carbonylation. This carbonylation reaction needs to be carried out under certain pressure and temperature conditions, and the reaction system should be kept anhydrous and oxygen-free. During operation, the raw materials, catalysts, bases, etc. are added to the high-pressure reactor in proportion, carbon monoxide is introduced, and the temperature and pressure are controlled. After the reaction, the product is processed to obtain a pure product.

Ethyl 2 - (trifluoromethyl) pyridine - 3 - carboxylic acid ester, this is an organic compound with unique physical properties. It is a colorless to pale yellow liquid, which is relatively stable at room temperature and pressure. Looking at its properties, it is often transparent, like clear water, but it hides chemical wonders.
Talking about the melting point, because the molecular structure contains trifluoromethyl and ester groups, it is different from conventional ester compounds. Its melting point is low, about -20 ° C to -10 ° C, just like winter ice, and it is easy to melt when warm.
The boiling point is related to the intermolecular force. Due to the strong electronegativity of trifluoromethyl, the intermolecular force changes. The boiling point is in the range of 180 ° C to 190 ° C. At a specific temperature, it is like a rising fog and turns into a gaseous state.
The solubility is also interesting. The compound is soluble in common organic solvents such as ethanol, ether, dichloromethane, etc. Like fish entering water, it fuses well with organic solvents, but it is difficult to dissolve in water. This property is due to its molecular polarity. The ester group and trifluoromethyl group make the molecule as a whole have a certain non-polarity, which is contrary to the polarity of water, so it is difficult to dissolve.
has a higher density than water, about 1.3 g/cm ³. If mixed with water, it will sink to the bottom like a stone and lie quietly in the lower layer.
In addition, its vapor pressure is low at room temperature, and the evaporation rate is slow, just like a quiet lake, with a calm surface. This physical property makes it relatively stable during storage and use, and it is not easy to evaporate quickly.

What I am asking you is about the market price of ethyl 2- (trifluoromethyl) pyridine - 3 - carboxylate. However, the price of this chemical is difficult to sum up, and it is affected by many factors.
First, the price and availability of raw materials have a great impact. If the starting materials required to prepare this compound are scarce or fluctuate widely, the price of the finished product will also fluctuate.
Second, the difficulty and cost of the production process are also key. Complex and high-cost processes will inevitably push up product prices. If new processes come out, which can simplify the process and reduce costs, the price may decline.
Third, the situation of market supply and demand, the price is very huge. If demand exceeds supply, the price will rise; on the contrary, if supply exceeds demand, the price will inevitably fall.
Fourth, regional differences also have an impact. In different places, prices may vary depending on transportation costs and tax policies.
According to past experience, in the chemical raw material market, such fluorine-containing heterocyclic ester compounds, if they are of ordinary purity, may cost between hundreds and thousands of yuan per kilogram. However, this is only a rough estimate, not an accurate value. To know the exact price, consult chemical product suppliers, trading platforms, or professionals in related industries to obtain a detailed estimate.

Ethyl 2 - (trifluoromethyl) pyridine - 3 - carboxylic acid esters are organic compounds. When storing and transporting, many matters must be paid attention to.
First, the storage place must be cool and dry. This compound is prone to chemical changes when heated. If it is exposed to a high temperature environment, or triggers reactions such as decomposition, it will damage its quality and stability. And a humid environment is also unfavorable. Moisture may react with the compound, affecting its purity.
Second, fire sources and oxidants must be isolated. Because of its flammability, in case of open flame or high temperature, there is a risk of fire or even explosion. And oxidants can also react violently with it, threatening safety.
Third, the storage container should be made of the right material. For example, use corrosion-resistant glass bottles or specific plastic containers to prevent the material of the container from interacting with the compound and causing it to deteriorate.
Fourth, the transportation process should be smooth to avoid violent vibration and collision. Otherwise, the container may be damaged, resulting in compound leakage.
Fifth, strictly follow relevant regulations and standards. Whether it is storage or transportation, it must comply with chemical management regulations, and make labels and records for traceability and management.
In conclusion, the storage and transportation of p-ethyl 2 - (trifluoromethyl) pyridine - 3 - carboxylic acid esters requires careful treatment and attention to many details to ensure their safety and quality.