Ethyl 2-pyridinecarboxylate

Ethyl-2-pyridinecarboxylate is widely used in the field of chemical medicine.
It is an important intermediate in organic synthesis. It can be combined with many reagents through specific chemical reactions to prepare other compounds containing pyridine structure. The structure of pyridine gives such products unique chemical properties and plays an indispensable role in drug research and development, pesticide creation, etc.
In the field of pharmaceutical chemistry, ethyl-2-pyridinecarboxylate may be converted into bioactive molecules through a series of reactions. Such molecules may be able to bind to specific targets in organisms, such as enzymes, receptors, etc., and then exhibit the efficacy of treating diseases. For example, there may be research and development using it as a starting material to synthesize drugs with antibacterial, anti-inflammatory and even anti-tumor activities.
In the field of pesticides, the pyridine-containing structure pesticides prepared on this basis have significant control effects on pests, pathogens, etc. Due to their unique chemical structure, they can efficiently interfere with the physiological and metabolic processes of pests and pathogens, so as to achieve the purpose of protecting crops.
In addition, in the field of materials science, some compounds of ethyl-2-pyridinecarboxylate participate in the synthesis, which may endow materials with special optical, electrical and other properties, providing assistance for the development of new functional materials. From this perspective, ethyl-2-pyridinecarboxylate plays a key role in many fields due to its unique chemical structure, promoting the development of chemical, pharmaceutical, agricultural and other industries.

Ethyl 2 - pyridinecarboxylate, which is ethyl 2 - pyridinecarboxylate, is a genus of organic compounds. Its physical properties are as follows:
Viewed at room temperature, it is a colorless to light yellow transparent liquid, clear and clear, without visible impurities.
It has a special smell, although it is not pungent and unpleasant, but it has a unique smell. It is common in organic synthesis sites.
When it comes to the boiling point, it is about 212 - 214 ° C. At this temperature, the substance gradually changes from liquid to gaseous. This boiling point characteristic allows it to be separated from other substances by distillation in experimental operations such as separation and purification, as well as in industrial production processes.
The melting point is about -43 ° C. When the temperature drops below the melting point, ethyl 2-pyridinecarboxylate solidifies from liquid to solid. Knowing this melting point allows you to know what low temperature environment to avoid during storage and transportation to prevent it from solidifying and affecting subsequent use.
Its density is about 1.109g/cm ³, which is slightly heavier than water. If placed in the same container as water, it will sink to the bottom of the water. This density characteristic is crucial in operations involving liquid-liquid separation.
Solubility, slightly soluble in water. Due to its molecular structure, only part of it can interact with water molecules. However, it is soluble in organic solvents such as ethanol and ether. This solubility provides a basis for selecting suitable solvents in organic synthesis, and is also conducive to efficient chemical reactions in homogeneous systems.
In addition, 2-ethyl pyridinecarboxylate has low vapor pressure and relatively weak volatility. At room temperature and pressure, its molecules have a small tendency to escape from the liquid surface to form steam, which is of great significance for storage and use safety, reducing the risk of combustion and explosion due to volatilization.

There are several common methods for the synthesis of ethyl 2-pyridinecarboxylate. One is to use 2-pyridinecarboxylic acid and ethanol as raw materials and perform esterification reaction under the condition of acid catalysis. In this process, sulfuric acid, p-toluenesulfonic acid, etc. are used as catalysts to heat and reflux to make the two fully react. The reaction mechanism is that the acid catalyst first protonates the carboxyl group to enhance the electrophilicity of the carboxyl carbon, and the hydroxyl oxygen of ethanol attacks the carboxyl group to form a tetrahedral intermediate. Then, through proton transfer and dehydration, ethyl 2-pyridinecarboxylate is formed.
There is also a method of reacting 2-pyridinecarboxylic acid chloride with ethanol. 2-Pyridineformyl chloride has a high activity and is prone to nucleophilic substitution when it meets ethanol. The hydroxyl oxygen of ethanol acts as a nucleophilic reagent to attack the carbonyl carbon of 2-pyridineformyl chloride, and the chlorine atom leaves to obtain the target product. This reaction is usually carried out in an alkaline environment, and the hydrogen chloride generated is absorbed by the acid binding agent to promote the positive progress of the reaction. Common acid binding agents include triethylamine, pyridine, etc.
Furthermore, it can be prepared from pyridine through a multi-step reaction. Pyridine is first reacted with the corresponding reagent, and a carboxyl group or its precursor is introduced at the second position, and then esterified. If pyridine is used as the starting material and reacted with carbon dioxide under appropriate conditions, the carboxyl group can be introduced at the 2 position of pyridine, and then reacted with ethanol according to the above esterification method to obtain ethyl 2-pyridine carboxylate. This route is a little complicated, but the raw material pyridine has a wide range of sources and also has practical value.

Ethyl + 2 - pyridinecarboxylate is also an organic compound. In the process of storage and transportation, many matters need to be paid attention to.
When storing, the first environmental conditions. When placed in a cool, ventilated warehouse, away from fire and heat sources. This is because it has certain chemical activity, high temperature or open flame can easily cause danger. The temperature of the warehouse should be controlled in a suitable range to avoid changes in its properties due to excessive temperature.
Furthermore, it should be stored separately from oxidants, acids, bases, etc., and should not be mixed. Because Ethyl + 2 - pyridinecarboxylate and other such substances can react chemically, or cause the risk of combustion and explosion. If it encounters with strong oxidizing agents, it is easy to cause severe oxidation reactions.
Packaging also needs to be tight to ensure that there is no risk of leakage. Choose suitable packaging materials to protect it from moisture and damage.
During transportation, the transportation vehicle should be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. During driving, it should be protected from exposure to the sun, rain and high temperature.
When loading and unloading, it should be handled lightly to prevent damage to packaging and containers. Operators need to wear suitable protective equipment to prevent physical damage caused by contact with the substance.
All of these are important points that cannot be ignored when storing and transporting Ethyl + 2 - pyridinecarboxylate, and must be done with caution to ensure safety.

The book "Tiangong Kaiwu" describes the changes in the skills and products of Baigong, but now I have inquired about the market price of "Ethyl 2 - pyridinecarboxylate". It is not included in the book, because it is not available at that time. This is an organic compound, named ethyl pyridinecarboxylate.
To know the market price of this compound, we need to look at the changes in the market of chemical raw materials. This compound is often used as an intermediate in the synthesis of medicines and pesticides, and its price is determined by many factors. First, the cost of raw materials is also high. If the price of raw materials such as pyridine and ethanol is high, the price will also rise. Second, the production process is complicated, the process is complex, the cost is high, and the price is also high. Third, the market supply and demand, more supply and less supply, the price will rise, and vice versa.
Generally speaking, the market price varies depending on the purity and batch size. High purity, large batch size, unit price or low. In the chemical raw material market, the price per kilogram may be between hundreds and thousands of yuan. If small quantities and experimental-grade products, the price may be higher; if a large number of industrial-grade products, the price may be lower. However, the market fluctuates frequently, and the price also changes from time to time. It is difficult to determine a fixed price range. For real-time prices, consult chemical suppliers, trading platforms, or recent market reports.