ethyl 2-methylpyridine-3-carboxylate

Ethyl 2-methylpyridine-3-carboxylate is an organic compound, which is a colorless to pale yellow liquid with a unique odor. This substance is widely used in the chemical and pharmaceutical fields.
In terms of chemical properties, its molecules contain pyridine rings, methyl groups and carboxylethyl ester groups. Pyridine rings are aromatic and have good stability. They can participate in electrophilic substitution reactions, and the substitution check point is affected by the substituent groups on the ring. Methyl groups as the power supply group will increase the electron cloud density of the pyridine ring, making the electrophilic substitution reaction more likely to occur, and mainly in the β position of the pyridine ring.
Carboxylethyl ester groups are active and can undergo hydrolysis reactions. Under acidic conditions, 2-methylpyridine-3-carboxylate is hydrolyzed to form 2-methylpyridine-3-carboxylate and ethanol; under basic conditions, carboxylate is hydrolyzed to form carboxylate and ethanol, which is often used to prepare corresponding carboxylic acids or carboxylate.
Ethyl 2-methylpyridine-3-carboxylate can also undergo ester exchange reaction. Under the action of catalysts, it can exchange alcohol parts with other alcohols to form new esters, which provides an effective path for the synthesis of specific structural esters. At the same time, its pyridine cyclic nitrogen atoms can complex with metal ions to form complexes, which have potential applications in the fields of catalysis and materials science.

The method of synthesizing ethyl 2-methylpyridine-3-carboxylate (ethyl 2-methylpyridine-3-carboxylate) has followed various paths in the past. First, it can be obtained by esterification of 2-methylniacin and ethanol. Among them, concentrated sulfuric acid is used as a catalyst to make the two co-heat at an appropriate temperature. Concentrated sulfuric acid has strong catalytic activity and can promote the reaction to the right. However, it also has drawbacks, such as strong corrosiveness and complicated post-processing. During the reaction, the temperature needs to be strictly controlled to prevent the growth of side reactions, such as dehydration of alcohols.
Second, the reaction of 2-methylpyridine-3-formyl chloride with ethanol can also be obtained. This reaction is relatively direct, and the activity of formyl chloride is quite high. When it meets ethanol, it reacts quickly. However, formyl chloride is not easy to prepare and has active properties. It needs to be carefully stored and used to prevent deterioration in contact with water or air.
There are also those who use 2-methyl-3-cyanopyridine as a raw material. It is first hydrolyzed to 2-methylnicotinic acid, and then esterified. This is a two-step reaction. In the hydrolysis step, acids or bases can be used as catalysts. When acid catalysis is used, sulfuric acid is commonly used; when alkali catalysis is used, such as sodium hydroxide solution. Subsequent esterification is similar to the first method.
Furthermore, it can be prepared by the substitution reaction of pyridine derivatives. Select an appropriate substitution reagent to introduce ethoxycarbonyl and methyl at a specific position in the pyridine ring. However, this path requires precise control of the reaction conditions to ensure the accuracy of the substitution check point. Due to the special distribution of electron clouds in the pyridine ring, the substitution positions are different under different conditions.
All these synthesis methods have their own advantages and disadvantages, and they need to be selected according to the actual situation, such as the availability of raw materials, cost, and the difficulty of reaction conditions.

Ethyl-2-methylpyridine-3-carboxylic acid ester is widely used and has important applications in many fields such as medicine, pesticides, and materials.
In the field of medicine, it is often used as a key intermediate in drug synthesis. Due to its unique chemical structure, it can participate in the construction of many drug molecules. It can be combined with other compounds through specific chemical reactions to create drugs with specific physiological activities. For example, some drugs used to treat cardiovascular diseases, in the synthesis process, ethyl-2-methylpyridine-3-carboxylic acid ester plays an indispensable role in the synthesis of pharmaceutical ingredients with precise curative effects.
In the field of pesticides, it is also an important raw material. Based on this, a variety of highly efficient pesticides can be prepared. For example, some new pesticides contain fragments derived from ethyl-2-methylpyridine-3-carboxylate in their molecular structures, which endow pesticides with excellent insecticidal activity and have significant control effects on specific pests. At the same time, they have relatively little impact on the environment, which is in line with the development trend of modern pesticides that are green and efficient.
In the field of materials, this compound also shows unique value. It can participate in the synthesis of functional materials, such as some materials with special optical and electrical properties. After rational chemical modification and polymerization, it can be introduced into the material structure, thereby improving the properties of the material, such as improving the stability, conductivity or optical response characteristics of the material, and opening up new paths for the research and development of new materials.
In summary, ethyl-2-methylpyridine-3-carboxylate plays a key role in the fields of medicine, pesticides, materials and other fields due to its unique chemical properties, and is of great significance for promoting technological progress and product innovation in these fields.

I think what you are asking is about the market price of ethyl 2-methylpyridine-3-carboxylate. However, the market price of this substance is difficult to say in a word.
The price of the compound is often affected by many factors. First, the price of raw materials. If the raw materials required for the synthesis of this compound are abundant and affordable, the price of ethyl 2-methylpyridine-3-carboxylate may also stabilize and decrease; if the raw materials are scarce, the price will rise, and the price of this compound will also rise.
Second, the method of preparation. If there is a sophisticated and efficient preparation process, the cost will be reduced, and the price will be close to the people; if the preparation is difficult, it will consume huge resources and man-hours, and the price will be high.
Third, market supply and demand. If the market demand for this product is strong and the supply is limited, merchants will raise the price to obtain a big profit; if the demand is weak and the supply is excessive, the price may fall to promote sales.
Fourth, the region varies. In different places, due to the differences in transportation costs, tax policies, and market competition, the price is also different.
To sum up, the market price of ethyl 2 - methylpyridine - 3 - carboxylate may often fluctuate, making it difficult to determine a fixed value in real time. To obtain an accurate price, it is necessary to check the market information of chemical raw materials, consult industry merchants, or refer to recent relevant transaction records to obtain a more accurate price.

Ethyl-2-methylpyridine-3-carboxylic acid ester is an organic compound, and its storage is essential to the stability and safety of the chemical substance. When storing this substance, the following conditions must be followed:
First, it must be stored in a cool place. High temperature can easily cause the compound to undergo chemical reactions, or cause it to decompose and deteriorate. Due to the increase in temperature, the molecular movement intensifies, or causes reactions such as bond breaking and rearrangement, so choose a cool place to keep its chemical structure stable.
Second, keep it in a dry place. Moisture or water vapor is easy to interact with the compound, or cause adverse reactions such as hydrolysis. The presence of moisture, or provide a reaction medium, changes the reaction path, so it is essential to avoid moisture.
Third, it should be stored in a well-ventilated place. The substance may be volatile. If the storage environment is not well ventilated, the volatile gas will accumulate. First, it is easy to cause air pollution. Second, it may have safety hazards such as explosion. Good ventilation can disperse the volatile gas in time.
Fourth, it is necessary to keep away from fire and heat sources. This compound may be flammable. In case of open flames and hot topics, it is very easy to burn or even explode. Therefore, fireworks are strictly prohibited in the storage area, and heat sources are controlled to prevent accidents.
Fifth, storage containers are also exquisite. Containers of suitable materials should be selected to ensure that they do not react with compounds. Generally speaking, containers made of glass or specific plastics are more suitable because of their relatively stable chemical properties, which can effectively preserve the substance.
Store ethyl-2-methylpyridine-3-carboxylic acid esters with caution and follow the above conditions to ensure their quality and safety.