ethyl 2-methyl-6-(trifluoromethyl)pyridine-3-carboxylate

Ethyl 2 - methyl - 6 - (trifluoromethyl) pyridine - 3 - carboxylate (2 - methyl - 6 - (trifluoromethyl) pyridine - 3 - carboxylate ethyl ester), which has a wide range of uses and plays an important role in the fields of medicine, pesticides and materials chemistry.
In the field of medicine, it is often a key intermediate. It can be chemically modified to access different active groups to synthesize compounds with specific pharmacological activities. For example, in some studies, it is used as a starting material to synthesize drug molecules with potential therapeutic effects on specific diseases such as cardiovascular diseases and nervous system diseases through multi-step reactions. The structure of Gainpyridine and trifluoromethyl plays an important role in regulating the lipid solubility, biological activity and metabolic stability of drug molecules in medicinal chemistry.
In the field of pesticides, it is also an important synthetic building block. Pyridine compounds often have good biological activity due to their unique structure. Based on this substance, pesticide products such as insecticides and fungicides can be developed. The introduction of trifluoromethyl can enhance the lipophilicity and stability of compounds, and improve the control effect of pesticides on pests and pathogens. For example, some new pyridine insecticides are synthesized with this compound as the key intermediate, which has an efficient killing effect on crop pests.
In the field of material chemistry, because it contains specific functional groups, it can participate in the synthesis and modification of materials. For example, in the synthesis of some high-performance polymer materials, it is introduced as a functional monomer to endow the material with special properties, such as improving the thermal stability, chemical stability and optical properties of the material. This is because the pyridine ring and trifluoromethyl in the structure can interact with the polymer molecular chain and affect the aggregate structure and properties of the material.

There are several common methods for the synthesis of pyridine-3-carboxylic acid esters of fuethyl-2 -methyl-6- (trifluoromethyl).
One is to start with a compound containing a pyridine structure. First take a suitable pyridine derivative, which needs a group that can be modified at the corresponding position of the pyridine ring. For example, select a pyridine with a specific substituent, and introduce a halogen atom at a specific position on the pyridine ring through a halogenation reaction. This halogen atom can provide an active check point for subsequent reactions. After that, the nucleophilic substitution reaction is used to induce the trifluoromethyl to replace the halogen atom with a reagent containing trifluoromethyl, such as a trifluoromethylation reagent, so as to introduce trifluoromethyl to the pyridine ring. Next, the methylation operation is carried out at another position on the pyridine ring, and a suitable methylation reagent can be selected. After a series of reaction conditions are adjusted to achieve the introduction of methyl groups. Finally, for the pyridine-3-carboxylic acid part, the esterification reaction is completed with ethanol under the action of esterification reagents to generate ethyl-2-methyl-6- (trifluoromethyl) pyridine-3-carboxylic acid esters.
Second, you can start from the construction of pyridine The pyridine ring structure is constructed by multi-step cyclization with suitable nitrile and carbonyl-containing raw materials, such as some nitrile compounds and carbonyl-containing compounds. During the cyclization process, the reaction steps and reagents are reasonably designed so that when the pyridine ring is formed, the desired substituents such as methyl and trifluoromethyl are carried out at specific positions. Then, the carboxylic acid part of the formed pyridine ring is esterified, and ethanol is used as the esterification reagent. In the presence of a suitable catalyst, the esterification reaction with ethanol is realized to obtain the target product ethyl-2-methyl-6- (trifluoromethyl) pyridine-3-carboxylic acid ester. This method requires precise control of the cyclization reaction conditions to ensure the accuracy of pyridine ring construction and the selectivity of substituent positions.
Or from other related heterocyclic compounds, through a series of reactions such as ring opening and rearrangement, it is gradually converted into target pyridine derivatives. First, the starting heterocyclic compound is ring-opened, and according to its structural characteristics, appropriate reaction conditions and reagents are selected to promote ring opening and generate intermediates with specific active groups. Then, through the rearrangement reaction, the structure of the intermediate is adjusted to construct the prototype of the pyridine ring. In the subsequent reaction, methyl, trifluoromethyl and other substituents are introduced in sequence, and the esterification is finally completed to obtain ethyl-2-methyl-6- (trifluoromethyl) pyridine-3-carboxylic acid ester. This approach requires a deep understanding of the mechanism and conditions of each step of the reaction to ensure the smooth progress of the reaction and the purity of the product.

Ethyl + 2 - methyl - 6 - (trifluoromethyl) pyridine - 3 - carboxylate is 2 - methyl - 6 - (trifluoromethyl) pyridine - 3 - carboxylate, the physical and chemical properties of this substance are as follows:
Looking at its shape, under room temperature and pressure, it is mostly colorless to light yellow liquid. It has a certain volatility and can evaporate slowly in the air. As far as its smell is concerned, it has a special smell of organic compounds, but the smell is not very strong and pungent.
When it comes to solubility, this substance exhibits good solubility in organic solvents, such as common ethanol, ether, dichloromethane and other organic solvents, which can be miscible with it. However, its solubility in water is quite limited, because the compound molecule contains more hydrophobic groups, such as methyl, trifluoromethyl, etc., making it difficult to form effective interactions with water molecules.
Boiling point and melting point are also key parameters characterizing its physical properties. Its boiling point is roughly within a certain range according to relevant literature and experimental data, and the value of this boiling point is affected by intermolecular forces. Due to the presence of fluorine atoms in the molecule, the electronegativity of fluorine atoms is extremely strong, resulting in a certain dipole-dipole interaction between molecules. At the same time, van der Waals forces also contribute to the boiling point. The melting point is also closely related to the structure of the molecule, and the symmetry of the molecule and the strength of the intermolecular forces jointly determine the melting point.
As for chemical properties, the ester group in this compound is an extremely active reaction check point. It can undergo hydrolysis under the catalytic conditions of acids or bases. Under acidic conditions, the hydrolysis reaction proceeds gradually to generate corresponding carboxylic acids and ethanol; while under basic conditions, the hydrolysis reaction proceeds more rapidly and thoroughly to generate carboxylate and ethanol. In addition, the substituents on the pyridine ring also affect its chemical properties. The presence of methyl groups and trifluoromethyl groups alters the electron cloud density distribution on the pyridine ring, which in turn affects the activity and check point selectivity of the pyridine ring for electrophilic substitution or nucleophilic substitution reactions. For example, trifluoromethyl groups are strong electron-absorbing groups, which will reduce the electron cloud density on the pyridine ring, resulting in electrophilic substitution reactions that are more likely to occur at relatively high electron cloud densities on the pyridine ring.

I am not aware of ethyl 2 - methyl - 6 - (trifluoromethyl) pyridine - 3 - carboxylate in the market price range. This compound is not a common and well-known product, and its price is determined by many factors.
First, the price varies depending on the source. If purchased from a large and large-scale chemical reagent supplier, they can often produce in large quantities, have stable supply, or have economies of scale, and the price may be relatively affordable. However, if purchased from a niche or specialized supplier, or because of its high production cost and limited output, the price will be high.
Second, purity is also key. For high-purity products, the preparation requires more complicated processes and more costs, so the price must be higher than that of low-purity products. For example, the price of high-purity products used in high-end scientific research and pharmaceutical research and development will far exceed that of industrial-grade lower-purity products.
Third, the state of market supply and demand also has an impact. If demand increases sharply for a while and supply is insufficient, prices will rise; conversely, if supply exceeds demand, merchants may reduce prices in order to destock.
Fourth, regional differences cannot be ignored. Different countries and regions have different prices due to different taxes, transportation costs, and local market competition.
To know the exact price range, consult chemical reagent suppliers, chemical product trading platforms, or consult relevant market survey reports to obtain accurate numbers.

Ethyl + 2 - methyl - 6 - (trifluoromethyl) pyridine - 3 - carboxylate, Chinese name ethyl 2 - methyl - 6 - (trifluoromethyl) pyridine - 3 - carboxylate, is a key intermediate in the field of organic synthesis, and is widely used in medicine, pesticides, materials and other industries.
However, at present, it is difficult for me to know the exact manufacturer of this compound. There are many manufacturers covering the world, and the chemical industry is changing with each passing day. New factories are constantly emerging, and old factories may change.
However, if you want to find a manufacturer of this compound, you can follow various channels. First, chemical products trading platforms, such as Gade Chemical Network, Mobell, etc., such platforms gather information on the supply of many chemical products, or can find manufacturers that produce ethyl + 2 - methyl - 6 - (trifluoromethyl) pyridine - 3 - carboxylate. Second, professional chemical exhibitions, such as China International Chemical Exhibition, many chemical companies will display their products here, or can communicate directly with the manufacturers of the compound. Third, industry reports and information, professional reports in the chemical industry, periodicals and magazines, or information about relevant manufacturers.
Although I cannot list the manufacturers of ethyl + 2 - methyl - 6 - (trifluoromethyl) pyridine - 3 - carboxylate one by one at this time, the above methods may be able to explore the required information and find the relevant manufacturers.