ethyl 2-chloropyridine-3-carboxylate

Ethyl-2-chloropyridine-3-carboxylic acid ester is also an organic compound. It has a wide range of uses and is mostly used as a key intermediate for the synthesis of drugs in the field of medicinal chemistry. The unique chemical structure of the Gainpyridine ring and ester group makes it possible to participate in a variety of chemical reactions and help to build complex drug molecular structures.
It also plays an important role in the creation of pesticides. It can be converted into compounds with insecticidal, bactericidal or herbicidal activities through specific reaction paths. Its structure can be finely adjusted to meet the needs of different pesticide action mechanisms, and to improve the activity and selectivity of pesticides to target organisms.
In the field of materials science, or can be used as a starting material for the synthesis of materials with special properties. By polymerizing or modifying with other compounds, materials are endowed with unique properties such as optical, electrical or thermal properties to meet the needs of different fields for special materials.
The application of this compound depends on the reactivity and characteristics endowed by its chemical structure, providing an indispensable basic raw material and key intermediate for innovation and development in many fields.

The method of synthesizing ethyl 2-chloropyridine-3-carboxylic acid esters has been investigated throughout the ages. Common ones are as follows.
First, pyridine-3-carboxylic acid is used as the starting material. First, pyridine-3-carboxylic acid and ethanol are esterified under the catalysis of concentrated sulfuric acid. This reaction needs to be refluxed at a suitable temperature to promote its ester formation to obtain ethyl pyridine-3-carboxylic acid. Then, pyridine-3-carboxylic acid ethyl ester is placed in a halogenating reagent, such as dichlorosulfoxide or phosphorus trichloride, with an appropriate amount of catalyst, and chlorination is carried out at an appropriate temperature. After these two steps, ethyl 2-chloropyridine-3-carboxylic acid ester can be obtained. During the esterification reaction, attention should be paid to temperature control, so as not to over-volatilize ethanol, and the amount of concentrated sulfuric acid should also be accurate to prevent side reactions from breeding. When chlorinating, the activity and dosage of halogenating reagents, as well as the reaction temperature, are all related to the purity and yield of the product.
Second, 2-chloropyridine-3-carboxylic acid is used as the raw material. 2-Chloropyridine-3-carboxylic acid is directly reacted with ethanol at a mild temperature with the help of a condensation agent such as dicyclohexyl carbodiimide (DCC) and a catalyst 4-dimethylaminopyridine (DMAP). This condensation reaction is more efficient and can avoid many side reactions caused by high temperature. However, DCC is expensive, and the post-reaction treatment requires the removal of its derived urea by-products, which slightly increases the complexity of the process. However, this method requires a high purity of the raw material 2-chloropyridine-3-carboxylic acid, otherwise it will also affect the quality of the product.
Third, the corresponding pyridine derivative is used as the starting material and is converted into a multi-step functional group. If a suitable substituent is introduced first to build the desired structure on the pyridine ring, and then a series of reactions such as esterification and halogenation are carried out to obtain the final target product. Although this path is complex, it can be flexibly adjusted according to the characteristics and availability of raw materials, and it is also a good strategy under specific circumstances. However, the connection and optimization of the conditions of each step of the reaction need to be carefully considered, and a slight error will affect the overall synthesis effect.

The market price of ethyl-2-chloropyridine-3-carboxylic acid esters varies from time to time and also varies due to many factors. Looking at the past "Tiangong Kaiwu", although there is no detailed description of the price of this specific product, the price of everything is related to supply and demand, the difficulty of production, and the availability of materials.
Now on ethyl-2-chloropyridine-3-carboxylic acid esters, if the supply exceeds the demand, the price will drop; if the demand exceeds the supply, the price will rise. And its production process, if it is very complicated, requires a lot of ingenious skills and time, and the materials used are rare and rare, the price is high; if the process is simple and the materials used are ordinary, the price may be low.
It is widely used in the field of chemical industry and is a raw material for many products. If the related industry is booming and the demand increases greatly, the price will also rise accordingly; on the contrary, the industry is sluggish, the demand is sluggish, and the price will decline.
Furthermore, the price varies depending on the region. In places where materials are abundant and convenient to make, the price may be relatively low; in places where materials are scarce and transshipment is difficult, the price must be high. However, in order to determine its current market price, it is necessary to consult the market of chemical materials, or check the detailed records of recent transactions, in order to obtain an accurate number, which is difficult to determine out of thin air.

Ethyl 2-chloropyridine-3-carboxylate, ethyl 2-chloropyridine-3-carboxylate, is one of the organic compounds. Its physical and chemical properties are quite important and it is widely used in the field of organic synthesis.
In terms of its physical properties, ethyl 2-chloropyridine-3-carboxylate is usually a colorless to light yellow liquid. Looking at its boiling point, it is about 230-232 ° C. This property allows it to be separated from other substances according to the difference in boiling point during separation operations such as distillation. Its density is about 1.22 g/cm ³, which is slightly higher than that of water. And the substance is slightly soluble in water, but can be well miscible with many organic solvents, such as ethanol, ether, dichloromethane, etc. This solubility provides convenience for the selection of suitable reaction solvents in organic synthesis.
As for chemical properties, chlorine atoms in 2-chloropyridine-3-carboxylate ethyl ester are highly active. This chlorine atom is prone to nucleophilic substitution reactions. For example, under alkaline conditions, it can react with nucleophiles such as alcohols and amines to generate corresponding substitution products. The ester group part can undergo hydrolysis reaction under acidic or basic conditions. Under acidic conditions, 2-chloropyridine-3-carboxylic acid and ethanol can be obtained by hydrolysis; under alkaline conditions, 2-chloropyridine-3-carboxylic acid and ethanol can be obtained by hydrolysis. After acidification, 2-chloropyridine-3-carboxylic acid can also be obtained.
Because of its special chemical structure of both chlorine atoms and ester groups, 2-chloropyridine-3-carboxylic acid ethyl ester is an important intermediate in the fields of drug synthesis, pesticide research and development, etc. Through the chemical transformation of its chlorine atoms and ester groups, many bioactive compounds can be constructed.

Ethyl 2-chloropyridine-3-carboxylate, Chinese name ethyl 2-chloropyridine-3-carboxylate, is an organic compound. During storage and transportation, many matters need to be paid attention to.
It has certain chemical activity and should be avoided from co-storage and co-transportation with strong oxidants, strong acids, strong bases, etc. Strong oxidants may cause intense oxidation reactions, strong acids and alkalis or chemical reactions such as hydrolysis, which damage its quality and even cause dangerous accidents.
Store in a cool, dry and well-ventilated warehouse, away from fires and heat sources. This compound is heated or decomposed, releasing harmful gases, and the temperature increases the reactivity, causing safety hazards. The temperature and humidity of the warehouse should be controlled within an appropriate range to prevent deterioration.
When transporting, the packaging must be complete and sealed. If the packaging is damaged, the material leaks, or reacts with substances in the environment, it will pollute the environment and pose a safety risk. The means of transportation should also be clean and dry to avoid residual oxidants, acid and alkali and other substances from reacting with it.
The handling process must be light and unloaded to prevent damage to the packaging container. Because it is a fine chemical, the packaging is mostly fragile containers such as glass bottles. During rough handling, the packaging will break and the material will leak.

During storage and transportation, warning signs, such as toxic, harmful, flammable, etc. should also be posted in accordance with the requirements of relevant chemical regulations, so that the contacts can understand the danger and take corresponding protective measures.
In addition, it is necessary to establish and improve the inbound and outbound registration system, record the storage quantity, inbound and outbound time and other information in detail, and then track and manage it. If there is any problem, it can be quickly traced back to the source.