Ethyl 2-aminopyridine-3-carboxylate

Ethyl 2-aminopyridine-3-carboxylate, that is, ethyl 2-aminopyridine-3-carboxylate, has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the synthesis of many drugs. The unique chemical activity of Gainpyridine ring with amino and ester groups can be used to construct compounds with complex structures and specific pharmacological activities through various chemical reactions. For example, when developing antibacterial drugs, it can participate in the reaction to build the core structure. After modification, it can enhance the affinity and effect of the drug on specific bacterial targets, and help to create high-efficiency antibacterial new drugs.
In the field of materials science, it also has important applications. Due to its own structural characteristics, it can participate in the polymerization reaction as a functional monomer to prepare polymer materials with special properties. For example, the synthesis of functional polymers with recognition and adsorption capacity for specific substances can be used for the efficient detection of specific pollutants in environmental monitoring, or in the separation and purification of specific components.
In addition, in organic synthetic chemistry, it is an important starting material for the construction of complex pyridine derivatives. With the help of various organic reactions, such as nucleophilic substitution, electrophilic substitution, etc., different functional groups can be introduced into its structure to realize the diversification and derivation of molecular structures, providing rich possibilities for organic synthetic chemists to create novel organic compounds, which greatly promotes the development of organic synthetic chemistry.

Ethyl 2-aminopyridine-3-carboxylate (ethyl 2-aminopyridine-3-carboxylate) has been synthesized in ancient times and has different routes.
First, pyridine-2,3-dicarboxylic acid is used as the starting material. First, pyridine-2,3-dicarboxylic acid and ethanol are esterified under the catalysis of concentrated sulfuric acid. This reaction needs to be carried out under heating conditions. Concentrated sulfuric acid acts as the catalyst and dehydrating agent to promote the reaction of the two to form diethyl pyridine-2,3-dicarboxylate. Subsequently, diethyl pyridine-2,3-dicarboxylate is reduced to an alcoholic hydroxyl group under the action of a suitable reducing agent, such as lithium aluminum hydride, to obtain 2-hydroxy-3- (ethoxycarbonyl) pyridine. Next, 2-hydroxy-3- (ethoxycarbonyl) pyridine and ammonia gas under high temperature and pressure and catalyst action, the hydroxyl group is replaced by an amino group to obtain Ethyl 2-aminopyridine-3-carboxylate.
Second, 2-halogenated pyridine-3-carboxylate is used as raw material. If the halogen atom in ethyl 2-halogenated pyridine-3-carboxylate is chlorine, bromine, etc., it can be reacted with ammonia sources, such as liquid ammonia or ammonia water, in suitable solvents, such as ethanol, dioxane, etc., under heating and catalyst action. The halogen atom is replaced by an amino group to synthesize the target product Ethyl 2-aminopyridine-3-carboxylate. In this reaction, the catalyst can be selected as a copper salt to promote the smooth progress of the reaction.
Third, use 2-nitropyridine-3-carboxylate as the starting material. Ethyl 2-nitropyridine-3-carboxylate can be reduced to amino groups under the action of reducing agents. Commonly used reducing agents include iron powder and hydrochloric acid, hydrogen and palladium carbon. Taking hydrogen and palladium carbon as an example, under the atmosphere of hydrogen and palladium carbon catalysis, 2-nitropyridine-3-carboxylate undergoes a reduction reaction, and the nitro group is gradually converted into an amino group, and finally Ethyl 2-aminopyridine-3-carboxylate is formed. This reaction condition is relatively mild and the product purity is high.

Ethyl 2-aminopyridine-3-carboxylate (ethyl 2-aminopyridine-3-carboxylate) is an organic compound with the following physical properties:
Viewed, it is often white to light yellow crystalline powder, which is quite common in many organic synthesis products. Its powder is fine in texture and has a fine luster under light.
As far as the melting point is concerned, it is about 83-86 ° C. The melting point is an important physical property of the substance. At this temperature range, the compound changes from solid to liquid state, which can help to identify purity and separate and purify. Under specific heating conditions, it can be seen that it gradually melts into a fluid state when it reaches this temperature range.
In terms of solubility, slightly soluble in water. Water is a common solvent, and the dissolution of this compound in this solvent is limited. Although it contains polar groups in its molecular structure, it still has a certain hydrophobicity as a whole. However, it is soluble in organic solvents such as ethanol and chloroform. Organic solvents such as ethanol can interact with the compound molecules by specific intermolecular forces, such as hydrogen bonds, van der Waals forces, etc., to achieve dissolution. In the experimental operation, a suitable organic solvent is selected to effectively disperse the compound and participate in the reaction.
In addition, its boiling point is about 294.5 ° C. The boiling point characterizes the temperature at which the compound transitions from liquid to gaseous state. This higher boiling point shows the relative stability of the compound, and a large amount of gasification will only be achieved at higher temperatures. In separation operations such as distillation, it is necessary to reach this boiling point before it can be separated from other low-boiling substances in gaseous form.
In summary, the physical properties of Ethyl 2-aminopyridine-3-carboxylate are of great significance in organic synthesis, analytical identification and related chemical operations, which can help researchers to use this compound rationally.

Ethyl 2-aminopyridine-3-carboxylate (ethyl 2-aminopyridine-3-carboxylate) is one of the organic compounds. Its chemical properties are unique, containing pyridine rings and functional groups such as amino and ester groups.
Among this compound, the pyridine ring is aromatic, with certain stability and electron delocalization characteristics. The amino group is basic and can react with acids to form corresponding salts. Under suitable conditions, the amino group can also participate in the nucleophilic substitution reaction and interact with electrophilic reagents such as halogenated hydrocarbons to form new nitrogen-containing derivatives.
The presence of ester groups endows the compound with hydrolytic properties. In acidic or alkaline environments, hydrolysis reactions can occur. Under acidic conditions, 2-aminopyridine-3-carboxylic acid and ethanol are hydrolyzed; under basic conditions, hydrolysis is more thorough, resulting in corresponding carboxylic salts and ethanol. In addition, ester groups can also participate in reactions such as ester exchange, exchanging alkoxy groups with other alcohols under the action of catalysts to prepare different ester compounds.
At the same time, due to the interaction of pyridine rings with amino groups and ester groups, the distribution of the entire molecular electron cloud changes, affecting its reactivity and selectivity. These chemical properties of this compound make it important in many fields such as organic synthesis and medicinal chemistry, and can be used as a key intermediate for the synthesis of compounds with more complex structures.

In today's world, it is difficult to know the price of ethyl 2-aminopyridine-3-carboxylate the market. This is because the market situation is complex, and the price varies with many factors.
Looking at the past "Tiangong Kaiwu", the price of goods often varies depending on the place of production, supply and demand, and time. The same is true for this ethyl 2-aminopyridine-3-carboxylate. If its production is wide, the raw materials are easy to obtain, and the production is easy, the price may be low; if the production is narrow, the raw materials are thin, and the production is difficult, the price will be high.
And the situation of supply and demand has a heavy shadow on the price. If there are many users, the demand is greater than the supply, and the price will rise; if there are few users, the supply will exceed the demand, and the price will drop. Changes over time, such as the weather, decrees, etc., can also make the price fluctuate.
To get the actual price, you can get a more accurate price when you visit various city shops, consult merchants, or check professional market information. However, without specific investigation, it is difficult to determine the range of the price. It is necessary to carefully investigate the market conditions and study many aspects to understand the price in the market.