ethyl 2-amino-6-(phenylmethyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate

Alas! Want to know the chemical structure of "ethyl + 2 - amino - 6- (phenylmethyl) -4,5,6,7 - tetrahydrothieno [2,3 - c] pyridine - 3 - carboxylate", and listen to me in detail.
This is the expression of the naming of organic compounds. "Ethyl", ethyl is also an alkyl group containing two carbon atoms, expressed as -CH -2 CH. "2 - amino" means that the 2-position has an amino group (-NH -2), which is connected to a specific position in the core structure of the compound. "6 - (phenylmethyl) ", that is, the 6-position is connected with a benzyl group (phenyl, -CH -2 - phenyl ring structure).
"4,5,6,7 - tetrahydrothieno [2,3 - c] pyridine" part, which is the core heterocyclic structure. "Thieno" refers to the thiophene ring, "pyridine" epipyridine ring, and the two are fused to form a special fused ring system. "4,5,6,7 - tetrahydro" indicates that the 4,5,6,7, and 7 positions of this fused ring system are hydrogenated, that is, saturated, and have no carbon-carbon double bonds.
"3 - carboxylate" shows that the 3-position is a carboxylate group, which is connected to "ethyl" to form a carboxylate ethyl ester structure (-COOCH 2 CH).
In summary, the chemical structure of this compound is composed of a thiophenopyridine fused ring containing specific substituents as the core, with benzyl at 6 positions, amino at 2 positions, and ethyl carboxylate at 3 positions. As a whole, it exhibits a complex and delicate organic molecular structure, which may have specific reactivity and potential uses in the research and application fields of organic chemistry.

Ethyl 2-amino-6- (phenylmethyl) -4,5,6,7-tetrahydrothieno [2,3-c] pyridine-3-carboxylate, this compound is named 2-amino-6-benzyl-4,5,6,7-tetrahydrothiopheno [2,3-c] pyridine-3-carboxylate. Its main use is often in the field of medicinal chemistry, because of its nitrogen-containing heterocyclic structure, it often has unique biological activity, or can become a key intermediate in drug development.
In the process of creating new drugs, researchers often use these compounds to modify and modify their structures in order to explore lead compounds with better pharmacological activity and pharmacokinetic properties. For example, some thiophenopyridine compounds, carefully designed and synthesized, show significant inhibitory or regulatory effects on specific disease-related targets, or are expected to become anti-cardiovascular diseases, anti-tumor drugs.
In addition, in the field of organic synthetic chemistry, this compound is also an important building block. Its structure has multiple activity check points, which can build more complex organic molecular structures through various organic reactions, contributing to the development of organic synthetic chemistry, and helping scientists explore more novel compounds and expand the boundaries of organic chemistry.

The synthesis of ethyl 2 - amino - 6 - (phenylmethyl) - 4,5,6,7 - tetrahydrothieno [2,3 - c] pyridine - 3 - carboxylate requires several steps.
The first step is to take thiophene and pyridine compounds with appropriate substituents as starting materials. For example, a thiophene derivative containing active groups can be selected to meet the pyridine precursor containing a reactive check point under suitable reaction conditions. Among them, the choice of solvent is quite important. Polar organic solvents such as dimethylformamide (DMF) or dichloromethane are often selected because they can help the reactants dissolve and promote the reaction.
Next, an amino group needs to be introduced. It can be achieved by an aminolysis reaction. The previous product is co-placed with ammonia gas or an appropriate reagent of ammonia at a suitable temperature and pressure. The temperature may be controlled in a moderate range, such as 50-100 ° C, and the pressure depends on the specific reaction, or it is normal pressure to slightly pressurized.
As for the introduction of benzyl (phenylmethyl), a nucleophilic substitution reaction can be used. React with a benzyl-containing halide, such as benzyl bromide or benzyl chloride, in the presence of a base. The base can be selected from potassium carbonate, sodium carbonate, etc., to promote the reaction to form the target product.
The last step is to form a carboxylic acid ethyl ester group. The product can be co-reacted with ethanol and suitable esterification reagents such as concentrated sulfuric acid or dicyclohexyl carbodiimide (DCC). The reaction needs to be at a suitable temperature, such as heating and reflux conditions, so that the esterification reaction can take place fully, and the final product is ethyl 2-amino-6- (phenylmethyl) -4,5,6,7-tetrahydrothieno [2,3-c] pyridine-3-carboxylate. After each step of the reaction, the product needs to be purified by methods such as column chromatography and recrystallization to ensure the purity and yield of the reaction.

Ethyl 2 - amino - 6- (phenylmethyl) - 4,5,6,7 - tetrahydrothieno [2,3 - c] pyridine - 3 - carboxylate is an organic compound. Its physicochemical properties are important for its performance in various chemical processes and practical applications.
When it comes to appearance, this compound is often presented in solid form, but the exact appearance will vary depending on the preparation method and purity, or it is a white to off-white crystalline powder with fine texture and uniform appearance.
Melting point, as one of the key physical properties, provides an important basis for identification and purity evaluation. The specific melting point of the compound needs to be accurately determined by experiments. Generally speaking, the melting point of the compound with a specific structure is within a relatively fixed range, but different studies or experimental conditions vary slightly.
The solubility cannot be ignored. In organic solvents such as ethanol and dichloromethane, the compound exhibits a certain solubility, which is convenient for it to be dissolved in the reaction system as a reactant or intermediate in the organic synthesis reaction, which promotes the smooth progress of the reaction. In water, its solubility is relatively poor, which is related to the large proportion of hydrophobic groups in the molecular structure.
From the perspective of chemical properties, the amino group in the molecule has a certain alkalinity, which can react with the acid to form the corresponding salt. The ester group can undergo hydrolysis reaction under the catalytic conditions of acid or base to form the corresponding carboxylic acid and alcohol. The presence of benzyl groups makes the compounds have certain aromaticity and can participate in typical reactions of aromatic compounds such as electrophilic substitution. In addition, the structure of tetrahydrothiophenopyridine endows the molecule with a unique electron cloud distribution and spatial configuration, which affects its chemical reaction activity and selectivity.
The physicochemical properties of this compound are of great significance in the fields of medicinal chemistry, materials science, etc. Researchers can carry out targeted research and applications based on these properties.

There are many derivatives related to ethyl-2-amino-6- (phenylmethyl) -4,5,6,7-tetrahydrothiopheno [2,3-c] pyridine-3-carboxylic acid esters. The core structure of this compound is unique, and a variety of derivatives can be obtained by modifying it.
A class of derivatives is a partial modification of benzyl. The addition or subtraction of substituents such as methyl, methoxy, and halogen atoms on the benzene ring can modify the electron cloud density and steric resistance, which affect the activity and binding characteristics of the compound. For example, the introduction of electron-absorbing halogen atoms can enhance the interaction with the target.
Another type is the modification of the pyridine ring or the thiophene ring. The introduction of different groups at specific positions on the pyridine ring can change the acidity, basicity and overall electronic structure of the compound, affecting its solubility in organisms and its ability to bind to proteins. Modification on the thiophene ring also changes the physical and chemical properties and biological activities of the compound.
Furthermore, the modification of the ester group, changing the ethyl ester group to other alkyl ester groups, such as methyl ester, propyl ester, or modifying it to an amide group, can improve the metabolic stability and membrane permeability of the compound. Amide derivatives may have better protein binding ability and better stability under certain physiological conditions.
In addition, the amino modification, the introduction of different groups through alkylation, acylation and other reactions, can modify the hydrophobicity and charge distribution of compounds, and affect their interaction mode and activity with biological targets.
The derivatives obtained from the above modifications may exhibit different biological activities in the field of pharmaceutical research and development, such as potential anti-tumor, antibacterial, anti-inflammatory and other activities, laying the foundation for the creation of new drugs.