ethyl 2,6-dimethylpyridine-3-carboxylate

Ethyl 2,6-dimethylpyridine-3-carboxylate, Chinese name 2,6-dimethylpyridine-3-carboxylate, is widely used. In the field of medicinal chemistry, it is often a key intermediate for the synthesis of various drugs. The structure of Gaiinpyridine ring is common in many bioactive molecules. After modifying 2,6-dimethylpyridine ring and ester group, compounds with different pharmacological activities can be prepared, such as antibacterial, anti-inflammatory, anti-tumor and other drugs.
In the field of materials science, it can be used to synthesize polymer materials with specific functions. Because the ester groups contained in it can be polymerized and connected with other monomers to build polymers with special properties, or in the field of optical materials and electronic materials, showing unique properties, such as improving the stability and solubility of materials.
In organic synthetic chemistry, as an important building block for organic synthesis, with its structural characteristics, it can participate in many organic reactions, such as nucleophilic substitution, oxidation and reduction. Through various reactions, it expands the structural diversity of organic compounds, lays the foundation for the synthesis of complex organic molecules, and facilitates the creation and research and development of new organic compounds.

The method of preparing ethyl 2,6-dimethylpyridine-3-carboxylic acid ester has been explored by chemists throughout the ages, and there are many methods, each with its own strengths.
First, 2,6-dimethylpyridine-3-carboxylic acid is used as the starting material to esterify it with ethanol under the catalysis of concentrated sulfuric acid. This reaction requires heating and reflux, and the principle is that concentrated sulfuric acid can promote the dehydration of the acid and alcohol to form ester bonds. During the reaction, it is necessary to pay attention to the control of temperature. If it is too high, it is easy to cause side reactions to occur and affect the purity of the product; if it is too low, the reaction rate will be slow. After the reaction is completed, the unreacted raw materials and by-products are removed by cooling, washing with water, liquid separation, etc., and then the organic phase is dried with a desiccant, and then purified by distillation to obtain pure ethyl 2,6-dimethyl pyridine-3-carboxylate.
Second, 2,6-dimethyl pyridine can be appropriately modified first, such as introducing suitable substituents on the pyridine ring to enhance its reactivity, and then nucleophilic substitution with reagents containing carboxyl ethyl ester structures. In this process, the requirements for reaction conditions are quite strict, such as the choice of reaction solvent, the amount and type of base, which will affect the reaction process and product yield. Suitable solvents can cause the reactants to fully dissolve and facilitate the reaction, while bases can adjust the pH of the reaction system and promote the reaction to the right.
Third, there are also methods of metal catalysis. Specific metal catalysts, such as palladium and copper, are selected to couple the halogenate containing the pyridine structure with the ethyl carboxylate derivative with the assistance of ligands. Such methods have relatively mild conditions and high selectivity, but the cost of metal catalysts is high, and the separation and recovery of the catalyst after the reaction is also a problem to be considered. There are various methods for preparing ethyl 2,6-dimethylpyridine-3-carboxylate, chemists need to weigh the advantages and disadvantages of each method according to actual needs, and choose the best method to implement.

Ethyl 2,6-dimethylpyridine-3-carboxylate (2,6-dimethylpyridine-3-carboxylate), its physical properties are as follows:
This substance is mostly liquid at room temperature and has a specific odor. However, the exact description of gas taste varies depending on individual olfactory differences. Its boiling point is about 230-235 ° C, which allows it to be separated from the mixture by distillation under specific temperature conditions. The melting point is relatively low, about -20 ° C, indicating that it is easy to maintain a liquid state at room temperature.
Its density is nearly 0.99-1.01g/cm ³, which is slightly lighter than water, so if mixed with water, it will float on the water surface. The substance is insoluble in water due to the existence of pyridine ring and ester group in the molecular structure, which makes it hydrophobic to a certain extent. However, it is soluble in common organic solvents, such as ethanol, ether, chloroform, etc. Due to the principle of similar phase dissolution, the molecular structure of organic solvents is similar to ethyl 2,6-dimethylpyridine-3-carboxylate, so it can be miscible with each other.
In addition, the refractive index of ethyl 2,6-dimethylpyridine-3-carboxylate is about 1.490-1.495. This physical constant can be used to identify the purity of the substance. The refractive index of the substance with different purity may be slightly different.

Ethyl-2,6-dimethylpyridine-3-carboxylic acid ester, the chemical properties of this compound are relatively stable. In its structure, the pyridine ring has aromatic properties, which endows the compound with certain stability. The methyl and ethyl ester groups on the ring have an impact on the electron cloud distribution of the pyridine ring due to the power supply effect of the methyl group and the conjugation effect of the ethyl ester group, but also stabilize the molecular structure to some extent.
From the perspective of reactivity, ethyl ester groups can undergo classic ester reactions such as hydrolysis, alcoholysis, and aminolysis. However, such reactions usually require specific conditions, such as hydrolysis or acid-base catalysis supplemented by heating, which is not easy to occur in ordinary environments, which also highlights the relative stability of their chemical properties. Substitution reactions on pyridine rings also require suitable reagents and conditions. Due to the electronegativity of the nitrogen atom in the pyridine ring, electrophilic substitution reactions are slightly more difficult than benzene rings, but they must be done.
In addition, the compound is generally not susceptible to common oxidation and reduction conditions without special reagents or harsh environments. Therefore, in general, the chemical properties of ethyl-2,6-dimethylpyridine-3-carboxylic acid esters are quite stable, and their chemical structures and properties can be maintained relatively constant under conventional storage and general operating environments.

Ethyl-2,6-dimethylpyridine-3-carboxylic acid ester is in the market, and its price range is difficult to determine. This is due to a variety of factors that can affect its price.
First, the source and quality of the material are related to the price. If the raw materials are easy to obtain and of high quality, the price may stabilize and be low; if the raw materials are rare and rare, it will be laborious to harvest, and the price will be high.
Second, the preparation method is also the main reason. The simple, efficient and cost-saving method can reduce the cost of production and make the price close to the people; if the production method is difficult, it requires a variety of reagents and harsh conditions, and the price will rise.
Third, the supply and demand of the city is the cardinal of the price. There are many people in need and few people in supply, so the price will rise; if the supply exceeds the demand, the price will fall.
Fourth, the reputation of the merchant and the land sold also make the price different. For well-known merchants, the price of their products may be high due to high quality and good after-sales service; in different places, due to taxes, transportation costs, etc., the price is also different.
As far as the current situation is concerned, although it is difficult to determine the range of its price, it is common sense that in the field of fine chemicals, the price may be between a few yuan per gram and a few tens of yuan. But this is only an idea, and the actual price still needs to be consulted with the supplier in detail before the exact number can be obtained.