ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CL-6-F-4-O-HYDROPYRIDINO[2,3-B]PYRIDINE-3-CARBOXYLATE

ETHYL 1- (2,4 - DIFLUOROPHENYL) -7 - CL - 6 - F - 4 - O - HYDROPYRIDINO [2,3 - B] PYRIDINE - 3 - CARBOXYLATE, this is the English name of an organic compound. To know its chemical structure, it can be disassembled and analyzed according to the naming convention.
"ETHYL", which means ethyl, is an alkyl group containing two carbon atoms, and its structure is simply -CH -2 CH. " 1- (2,4 - DIFLUOROPHENYL) ", indicating that a 2,4-difluorophenyl group is connected at position 1 of the main structure. Positions 2 and 4 on this phenyl group are replaced by fluorine atoms, and the structure is that fluorine atoms are connected at specific positions on the benzene ring.
" 7 - CL - 6 - F - 4 - O - HYDROPYRIDINO [2,3 - B] PYRIDINE ", this part is a fused heterocyclic structure. Pyridine [2,3-B] pyridine, with a chlorine atom (CL) substituted at position 7, a fluorine atom (F) substituted at position 6, and a hydroxyl group at position 4 (4-O-HYDRO, expressed here or incorrectly, normally 4-HYDROXY refers to hydroxy-OH).
"3-CARBOXYLATE", indicating that there is a carboxylic acid ester group connected at position 3, combined with the beginning "ETHYL", it can be known that it is a carboxylic acid ethyl ester group-COOCH -2 CH.
In summary, the chemical structure of this compound is based on pyridino [2,3-B] pyridine as the core parent ring, with fluorine, chlorine, and hydroxyl substitutions at specific positions on the ring, and the No. 1 position is connected to 2,4-difluorophenyl, and the No. 3 position is connected to carboxylic acid ethyl ester. This structure may endow the compound with specific chemical and physical properties, which may have potential uses in organic synthesis, pharmaceutical chemistry, and other fields.

ETHYL 1- (2,4-DIFLUOROPHENYL) -7-CL-6-F-4-O-HYDROPYRIDINO [2,3-B] PYRIDINE-3-CARBOXYLATE is an organic compound. It has specific physical properties.
Looking at its properties, it may be a crystalline solid under normal conditions, because this class of organic compounds containing polycyclic and specific substituents often appear in this state, and the mass state is relatively stable, which is conducive to storage and operation.
When it comes to the melting point, in view of the presence of aromatic rings, chlorine, fluorine and other atoms and groups in the molecule, the interaction leads to increased intermolecular force, and the melting point is expected to be high, or between 150-250 ° C. This property is crucial in the purification and identification of compounds, and its purity can be judged by melting point measurement.
In terms of solubility, the molecules contain polar ester groups and non-polar aromatic rings, and their solubility in organic solvents is different. In polar organic solvents such as ethanol and acetone, or have a certain solubility, because the ester groups can form hydrogen bonds or dipole-dipole interactions with polar solvents; while in non-polar solvents such as n-hexane, the solubility is low, because the non-polar part is not enough to be well miscible with non-polar solvents.
In addition, the compound contains halogen atoms such as fluorine and chlorine, causing its density to be greater than that of water. When it comes to operations such as liquid-liquid separation, this property can be used as a basis to help the compound separate from the mixture. Its stability is also worthy of attention. In view of the structure of aromatic rings and heterocycles, the chemical stability is relatively high, but under extreme conditions such as strong acids, strong bases or high temperatures, functional groups such as ester groups may react and cause structural changes.

ETHYL 1- (2,4 -DIFLUOROPHENYL) -7-CL-6-F-4-O-HYDROPYRIDINO [2,3 -B] PYRIDINE-3-CARBOXYLATE is an organic compound, and its nomenclature follows the nomenclature of organic chemistry. This compound has important uses in many fields.
In the field of medicinal chemistry, such compounds containing fluoropyridine and pyridine structures often have unique biological activities, or can be used as potential drug lead compounds. The introduction of fluorine atoms can change the fat solubility, metabolic stability and interaction ability of compounds with biological targets. Researchers can develop drugs for specific diseases, such as tumors and inflammation-related diseases, by modifying and optimizing their structures. For example, some fluoropyridine compounds can inhibit the activity of specific protein kinases, regulate cell signaling pathways, and then provide new ideas for tumor treatment.
In the field of pesticide chemistry, the compound may have insecticidal, bactericidal or herbicidal activities. The structure of pyridine and pyridine can endow the compound with good biological activity, and the presence of fluorine atoms may enhance its effect on pests and pathogens. Due to the special properties of fluorine atoms, the compound may have good environmental stability and selectivity, which can ensure agricultural production while reducing negative environmental impacts.
In the field of materials science, such organic compounds may be used to prepare functional materials. For example, they can participate in the synthesis of materials with specific photoelectric properties, and are used in the fields of Light Organic Emitting Diode (OLED), solar cells, etc. Due to its structural designability, it can optimize the electrical and optical properties of materials by adjusting the substituents to meet the needs of different material applications.
In short, ETHYL 1- (2,4 -DIFLUOROPHENYL) -7-CL-6-F-4-O-HYDROPYRIDINO [2,3 -B] PYRIDINE-3-CARBOXYLATE has shown potential application value in many fields such as medicine, pesticides and materials science, attracting many researchers to explore in depth.

ETHYL 1- (2,4 - DIFLUOROPHENYL) -7 - CL - 6 - F - 4 - O - HYDROPYRIDINO [2,3 - B] PYRIDINE - 3 - CARBOXYLATE is 1- (2,4-difluorophenyl) -7-chloro-6-fluoro-4-hydroxypyridino [2,3-b] pyridine-3-carboxylate ethyl ester, which is synthesized by many methods, which are selected to be described below.
Take 2,4-difluoroaniline first, and use an appropriate halogenation reagent, such as thionyl chloride, etc., at a suitable temperature and reaction environment, carry out a halogenation reaction to obtain the key intermediate halogenated 2,4-difluoroaniline derivatives. This derivative is then combined with a substrate containing a pyridine structure, under alkali catalysis, such as potassium carbonate and other basic substances, in an organic solvent, such as N, N-dimethylformamide (DMF), through condensation reaction, to construct the core skeleton of pyrido [2,3-b] pyridine.
The resulting product is then halogenated, and a suitable halogenating agent, such as N-chlorosuccinimide (NCS), is selected. In the presence of light or initiator, 7-chloro substitution is achieved in an inert solvent, such as dichloromethane. Afterwards, the nucleophilic substitution reaction is used to achieve 6-fluorine substitution in polar solvents such as acetonitrile with fluorides, such as potassium fluoride, etc., assisted by phase transfer catalysts, such as tetrabutylammonium bromide (TBAB).
Finally, the 4-hydroxy group is modified by esterification reaction. The above product is taken with ethanol, and under the action of catalysts such as concentrated sulfuric acid, heated and refluxed to complete the ethylation process, thereby preparing ETHYL 1- (2,4 - DIFLUOROPHENYL) -7 - CL - 6 - F - 4 - O - HYDROPYRIDINO [2,3 - B] PYRIDINE - 3 - CARBOXYLATE. Throughout the synthesis process, attention should be paid to the control of the conditions of each step of the reaction to ensure the smooth progress of the reaction and the purity and yield of the product.

ETHYL 1- (2,4 - DIFLUOROPHENYL) -7 - CL - 6 - F - 4 - O - HYDROPYRIDINO [2,3 - B] PYRIDINE - 3 - CARBOXYLATE is a chemical. When using it, many things need to be paid attention to.
First safety protection. This chemical may be corrosive, irritating or toxic. When using it, be sure to wear appropriate protective equipment, such as gloves, goggles and lab clothes. Gloves are selected to be chemically resistant to prevent their penetration. Goggles protect the eyes from splashes. The lab clothes protect the body and reduce the risk of chemical contact with the skin.
Second words operating environment. It is necessary to work in a well-ventilated place, preferably in a fume hood. This can disperse volatile harmful gases in time, reduce the concentration in the air, and prevent inhalation hazards. And the operating table must be clean, dry and flat to avoid impurities from mixing into the reaction, and at the same time prevent the container from tipping over due to uneven table surface, causing leakage.
Furthermore, it is related to storage. It should be stored in a cool, dry and ventilated place, away from fire sources, heat sources and oxidants. Because of its flammability, it may encounter open flames, hot topics or cause combustion. Different chemicals mix or react, and must be stored separately, and marked, indicating the name, specification and date, for easy management and access.
During operation, accurate dosage is extremely critical. According to experimental or production requirements, measure with the help of accurate measuring tools. Too much dosage or excessive reaction, too little or incomplete reaction. Seal the container in time after measurement to prevent it from absorbing moisture, oxidizing or volatilizing.
In addition, you should also be familiar with emergency treatment methods. If you accidentally come into contact with the skin, rinse with a large amount of flowing water immediately, and then seek medical treatment. If it splashes into the eyes, immediately open the eyelids and rinse with flowing water or normal saline. You also need to seek medical attention as soon as possible. In case of leakage, quickly evacuate unrelated personnel, isolate the scene, and strictly prohibit fireworks. Small leaks should be absorbed with inert materials such as sand and vermiculite; large leaks should be contained by building a dike or digging a pit, and then transferred to a tanker or special container for recycling or harmless treatment.