dimethyl (4S)-2,6-dimethyl-4-(2-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate

Eh, this "dimethyl (4S) -2,6-dimethyl-4- (2-nitrophenyl) -3,4-dihydropyridine-3,5-dicarboxylate" is the English name of an organic compound. To clarify its chemical structure, let me tell you in detail.
In this compound name, "dimethyl" shows dimethyl. " (4S) " The chiral center is at the 4th position and the configuration is S. "2,6-dimethyl" indicates that the 2nd and 6th positions are connected with a methyl group. "4- (2-nitrophenyl) " means that the 4th position is connected with 2-nitrophenyl. "3,4-dihydropyridine" shows that its core structure is 3,4-dihydropyridine ring. " 3,5-dicarboxylate "appears to have carboxylic acid ester groups at both the 3rd and 5th positions.
In our opinion, its chemical structure is roughly as follows: first there is a 3,4-dihydropyridine ring as the base, and the 2nd and 6th positions of the ring are each added with a methyl group; the 4th position is connected with 2-nitrophenyl group; the 3rd and 5th positions of the ring are connected with carboxylate groups, respectively. As for the chiral center 4 position, according to the rule of" (4S) ", the atomic space arrangement has a specific stereochemical configuration.
In this way, the chemical structure of this compound is roughly clear.

The physical properties of dimethyl (4S) -2,6-dimethyl-4- (2-nitrophenyl) -3,4-dihydropyridine-3,5-dicarboxylate are of great value for investigation.
Looking at its properties, at room temperature, it is either solid or liquid, but the specific form needs to be determined by precise experiments. In terms of color and luster, it may be colorless and transparent, as clear as a spring; or slightly dyed, like light yellow, light brown, etc., which are closely related to the molecular structure and the presence of impurities. < Br >
The melting point and boiling point are discussed. The melting point is related to the strength of the intermolecular force and the lattice structure. When the temperature rises to a certain value, the lattice disintegrates and the solid state gradually melts; the boiling point is closely related to the intermolecular force and vapor pressure. When it reaches the boiling point, the liquid quickly turns into a gaseous state. However, in order to know the exact melting point and boiling point values, rigorous experimental measurement is required.
In terms of solubility, it varies in different solvents. Organic solvents such as ethanol and ether may dissolve due to their similar compatibility; in water, they may be insoluble or slightly soluble due to the matching degree of molecular polarity and water molecules.
Density is also one of the important physical properties, which is related to the molecular mass and the degree of intermolecular accumulation. The density affects the ups and downs of this substance in different media, and has a profound impact on its practical application.
In addition, the refractive index cannot be ignored. When light passes through this substance, due to the refraction of molecules on light, the refractive index reflects the molecular structure and arrangement characteristics, which can provide an important basis for identification and purity analysis.
In conclusion, the physical properties of dimethyl (4S) -2,6-dimethyl-4- (2-nitrophenyl) -3,4-dihydropyridine-3,5-dicarboxylic acid esters are mentioned before in-depth understanding of their properties and applications. Many properties need to be accurately defined by detailed experiments.

To prepare dimethyl (4S) -2,6-dimethyl-4- (2-nitrophenyl) -3,4-dihydropyridine-3,5-dicarboxylic acid ester, the method is as follows:
First take the appropriate starting material, which needs to contain the structural unit capable of constructing the pyridine ring. It can be started by the condensation reaction of aldehyde, ketone and nitrogen-containing compounds with specific substituents. For example, 2-nitrobenzaldehyde and ketones with dimethyl substitution are condensed under suitable catalysts and reaction conditions to construct part of the structure of the pyridine ring. The catalyst for the
reaction can be selected from an organic base or an inorganic base, such as piperidine, sodium carbonate, etc. The solvent for the reaction can be selected from alcohols, ethers or aromatics, depending on the specific requirements of the reaction and the solubility of the substrate.
After the condensation reaction is completed, the product needs to be treated to obtain the crude product of the target product. This process may involve extraction, filtration, distillation and other operations to separate unreacted raw materials and by-products.
After the crude product is obtained, it can be further purified by recrystallization, column chromatography and other means. During recrystallization, an appropriate solvent system is selected to make the target product have a suitable solubility difference in it, so that the crystallization can be precipitated and impurities can be removed. Column chromatography is based on the distribution coefficient of the target product and impurities between the stationary phase and the mobile phase to achieve separation and purification.
The whole preparation process requires fine control of the reaction conditions, such as temperature, reaction time, proportion of reactants, etc., in order to improve the yield and purity of the product, to obtain dimethyl (4S) -2,6-dimethyl-4- (2-nitrophenyl) -3,4-dihydropyridine-3,5-dicarboxylate.

This compound is called dimethyl (4S) -2,6-dimethyl-4- (2-nitrophenyl) -3,4-dihydropyridine-3,5-dicarboxylate, and its main use is often related to the field of medicinal chemistry.
In the process of pharmaceutical creation, this compound can be used as a key intermediate. Due to its unique molecular structure, it can be cleverly linked with other chemical groups by organic synthesis methods to construct complex molecules with specific biological activities. For example, in the development of cardiovascular diseases, the final product of the synthesis of this intermediate may have a regulatory effect on calcium ion channels. Calcium ions play a key role in myocardial contraction and vascular smooth muscle relaxation, and precisely regulate calcium ion channels, which can effectively improve cardiovascular function and relieve diseases such as hypertension and angina pectoris.
Furthermore, this compound is also of great value in the exploration of the structure-activity relationship of pharmaceutical chemistry. Scientists can carefully observe the corresponding changes in biological activity by modifying and changing the specific position of its structure. Through systematic research, the correlation between molecular structure and biological activity can be deeply understood, providing precise guidelines for subsequent drug design, and helping to develop innovative drugs with better efficacy and fewer side effects.
In the field of organic synthetic chemistry, this compound may be used to construct special pyridine derivatives. Pyridine compounds widely exist in various natural products and drug molecules, and their unique chemical properties endow the compounds with diverse reactivity and biological activity. With this compound as a starting material, through a series of chemical reactions, novel pyridine derivatives can be prepared, which provides a new research direction and material basis for organic synthetic chemistry.

The chemical reactions related to dimethyl (4S) -2,6-dimethyl-4- (2-nitrophenyl) -3,4-dihydropyridine-3,5-dicarboxylic acid esters are quite rich.
First, the compound contains a dihydropyridine ring, which has a certain degree of reduction. Under the action of a suitable oxidant, such as potassium permanganate, the dihydropyridine ring can be oxidized to form pyridine derivatives. This reaction is similar to the refining in a kettle. Depending on the conditions, the structure of the product is also different.
Second, the ester group in the molecule can undergo hydrolysis reaction. In an acidic or alkaline environment, the ester group seems to be skillfully disassembled. In acidic media, hydrolysis is slow, and the corresponding carboxylic acids and alcohols are finally obtained; under alkaline conditions, hydrolysis is rapid, and carboxylic salts and alcohols are formed, which are like paotene to dissolve cattle, and each belongs to its place.
Third, the 2-nitrophenyl group can participate in the reaction. Nitro groups can be reduced. For example, with reducing agents such as iron powder and hydrochloric acid, the nitro group gradually changes to an amino group, which seems to replace the compound with a new "crown".
Fourth, this substance may also participate in nucleophilic substitution reactions. Due to the difference in the distribution of electron clouds on the dihydropyridine ring and the benzene ring, nucleophilic reagents can attack the appropriate check point and replace it, just like finding a place and living, Such reaction conditions are meticulous, and the proportion of reactants and solvent selection can all affect the reaction process and products.