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What is the chemical structure of Benzyl 4- (Hydroxymethyl) Tetrahydro-1 (2H) -Pyridinecarboxylate
The chemical structure of benzyl 4- (hydroxymethyl) tetrahydro-1 (2H) -pyridine carboxylic acid esters is an important topic in the field of organic chemistry. This compound has a complex and delicate structure and contains a unique chemical structure.
Its main body is the tetrahydro-1 (2H) -pyridine ring. This ring is quite common in organic synthesis and pharmaceutical chemistry. It has a unique electron cloud distribution and spatial configuration, which has a profound impact on the physical and chemical properties of compounds. The 4-position of the ring is connected to hydroxymethyl groups, and the hydroxyl groups in the hydroxymethyl group have active chemical activity and can participate in many chemical reactions, such as esterification and etherification, giving the compounds rich reactivity. < Br >
And benzyl is connected to the first position of the pyridine ring. Benzyl is composed of phenyl and methylene. The conjugate system of phenyl imparts certain stability and hydrophobicity to the compound, and methylene is the connecting part, so that benzyl is connected to the pyridine ring. In this structure, the pyridine ring interacts with benzyl and hydroxymethyl to jointly determine the overall properties of the compound. The nitrogen atom of the pyridine ring, due to its lone pair of electrons, can participate in the reaction as a nucleophilic check point, and also contribute to the polarity and basicity of the molecule. Overall, the chemical structure of benzyl 4- (hydroxymethyl) tetrahydro-1 (2H) -pyridyl carboxylate is composed of a unique ring system, active functional groups and substituents. Its complex and delicate structure lays a solid foundation for the study of its chemical properties and applications.
What are the main uses of Benzyl 4- (Hydroxymethyl) Tetrahydro-1 (2H) -Pyridinecarboxylate
Benzyl-4- (hydroxymethyl) tetrahydro-1 (2H) -pyridyl carboxylate is an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry.
This compound plays an important role in the synthesis of many drugs. Because of its unique structure, specific reactivity and spatial configuration, it can undergo various chemical reactions to construct complex drug molecular structures. For example, in the preparation of drugs for the treatment of certain neurological diseases, with the help of its hydroxymethyl and pyridyl carboxylate groups, it can precisely react with other compounds to achieve the construction of target drug molecules, help develop specific drugs, and bring good news to patients.
In the field of materials science, it has also made a name for itself. Some of its properties can be modified and applied to the creation of new materials. For example, introducing it into polymer materials through specific reactions may endow materials with unique properties, such as better biocompatibility, special optical or electrical properties, etc., opening up new paths for the development of materials science, promoting the emergence of new functional materials, and meeting the stringent requirements of material properties in different fields.
In the field of organic synthetic chemistry, benzyl-4- (hydroxymethyl) tetrahydro-1 (2H) -pyridine carboxylate is a key synthetic building block due to its own structural characteristics. Chemists can use it to perform various organic reactions, such as nucleophilic substitution, redox, etc., to expand the diversity of organic molecular structures, inject vitality into the study of organic synthetic chemistry, promote the discovery and creation of novel organic compounds, and promote the continuous development of this field.
What is the synthesis method of Benzyl 4- (Hydroxymethyl) Tetrahydro-1 (2H) -Pyridinecarboxylate
To prepare benzyl 4- (hydroxymethyl) tetrahydro-1 (2H) -pyridinecarboxylic acid ester, the method is as follows:
First prepare the required raw materials, benzyl alcohol, 4- (hydroxymethyl) tetrahydro-1 (2H) -pyridinecarboxylic acid, etc., and all should be pure and free of impurities. Also prepare suitable solvents, such as dichloromethane, etc., which need to be stable in nature, soluble in all raw materials and do not change from the reactants.
In a clean reaction vessel, add benzyl alcohol and 4- (hydroxymethyl) tetrahydro-1 (2H) -pyridinecarboxylic acid in an appropriate ratio with a precise gauge. After pouring, slowly inject the prepared solvent to dissolve the raw materials into a uniform mixture.
Then, add an appropriate amount of condensation agent, such as dicyclohexyl carbodiimide (DCC), etc., which can promote the esterification reaction. After adding, stir at a constant speed with a magnetic stirrer or a mechanical stirrer to make the mixture uniform, and the temperature control is within a suitable range, generally about room temperature to 50 degrees Celsius, depending on the actual reaction.
When the reaction is carried out, it is often monitored by thin chromatography (TLC) to clarify the reaction process. When the raw material point fades away and the product point is clear and no longer changed, the reaction is nearly complete. After the
reaction is completed, pour the reaction solution into an appropriate amount of dilute acid solution, such as dilute hydrochloric acid, to quench the unreacted condensation agent and other impurities. Then, extract with an organic solvent such as ethyl acetate, and separate the organic phase.
The organic phase is dried with a desiccant such as anhydrous sodium sulfate, except for the moisture in it. After that, the solvent is evaporated with a rotary evaporator to obtain a crude product.
The crude product is then refined by column chromatography and other methods, and a suitable eluent is selected, such as a mixture of petroleum ether and ethyl acetate, and mixed in an appropriate proportion. After this, a pure benzyl 4- (methyl hydroxyl) tetrahydro-1 (2H) -pyridine carboxylate product can be obtained.
What are the physical and chemical properties of Benzyl 4- (Hydroxymethyl) Tetrahydro-1 (2H) -Pyridinecarboxylate
Benzyl 4- (hydroxymethyl) tetrahydro-1 (2H) -pyridinecarboxylate, this is an organic compound. Its physical and chemical properties are crucial and related to many practical applications.
When it comes to appearance, it is often in the state of white to off-white crystalline powder, with fine texture and pure color. This form is easy to store and use, and also lays the foundation for its application in many fields.
In terms of solubility, it shows unique properties in organic solvents. In common organic solvents such as ethanol and dichloromethane, it has certain solubility. As a common organic solvent, ethanol can form a homogeneous solution with this compound, which makes it a good reaction medium in organic synthesis reactions, which is conducive to the efficient progress of various reactions. In water, the solubility is relatively limited, which is related to the functional groups contained in its molecular structure, resulting in poor hydrophilicity.
Melting point is also one of the important physical properties. After measurement, its melting point is within a specific range. The melting point is stable, reflecting the stable intermolecular force and relatively regular structure of the compound. This property is of great significance in the purification and identification of the compound. The purity and authenticity can be preliminarily judged by the measurement of the melting point.
Chemical properties, the ester groups in the compound can undergo hydrolysis. Under acidic or basic conditions, ester groups can be hydrolyzed to form corresponding carboxylic acids and alcohols. Hydrolysis is more thorough under alkaline conditions, and this hydrolysis reaction can be used in organic synthesis to prepare specific carboxylic acid compounds. The hydroxymethyl groups in its molecules have active chemical properties and can participate in oxidation reactions. They can be oxidized to aldehyde groups and even carboxyl groups, which enriches their reaction paths in organic synthesis and provides the possibility for the synthesis of more complex organic compounds. The structure of the pyridine ring gives it a certain alkalinity and can react with acids to form salts. This property is helpful in drug development to improve the solubility and stability of compounds and enhance drug efficacy.
In summary, benzyl 4- (hydroxymethyl) tetrahydro-1 (2H) -pyridinecarboxylate has unique physicochemical properties and plays an important role in organic synthesis, drug development, and other fields, providing many possibilities for the development of related fields.
What is the price range of Benzyl 4- (Hydroxymethyl) Tetrahydro-1 (2H) -Pyridinecarboxylate in the market?
I have not heard of the exact price range of "Benzyl 4- (Hydroxymethyl) Tetrahydro-1 (2H) -Pyridinecarboxylate" in the market. However, if you want to know its price, you can go through many ways.
First, on chemical raw material trading platforms, such platforms often gather many suppliers and buyers to list the prices of various chemicals. If this compound is common, it may be able to get the prices quoted by different sellers here, which vary depending on the quality, purity and quantity.
Second, consult chemical product distributors. They have been involved in the industry for a long time, have a wide range of contacts, are familiar with market conditions, and can roughly tell the price range according to their own operations and the situation of their peers.
Third, look at relevant academic literature and research reports. Although it is not a direct price information, its preparation cost, application field and other information may help to predict the market price. If the preparation is complicated and the raw materials are expensive, the price may be high; if the application is niche and the demand is limited, the price will also be affected.
Unfortunately, I don't have real-time market data on hand, so I can't directly state the price range. You can follow the above method to explore its market price.