alpha.-(4-chlorophenyl)-2-Pyridinemethanol

"Alpha- (4-cyanobenzyl) -2-pyridyl acetic acid" is an organic compound. Its chemical properties are quite rich, let me tell them one by one.
From an acidic perspective, it is acidic because its structure contains a carboxyl group (-COOH). The oxygen atom in the carboxyl group is quite electronegative, which makes the hydrogen-oxygen bond electron cloud biased towards oxygen, and the hydrogen atom is easily dissociated in the form of protons, thus showing acidity. In a chemical reaction, it can neutralize with a base, such as when it encounters sodium hydroxide (NaOH), and the hydrogen in the carboxyl group binds to hydroxide to form water to form the corresponding carboxylate, that is, alpha - (4-cyanobenzyl) -2-pyridyl acetate sodium.
The presence of cyano (-CN) gives the compound its unique reactivity. The cyano group can undergo a hydrolysis reaction, and it can be gradually converted into a carboxyl group or an amide group under acid or base catalysis conditions. When hydrolyzed under acidic conditions, the cyano group first changes to an amide group (-CONH ²), and if the hydrolysis is complete, it further changes to a carboxyl group. Hydrolyzed under basic conditions, carboxylate and ammonia (or ammonium salt) are formed
Furthermore, the pyridine ring also affects its chemical properties. The pyridine ring is aromatic, and its nitrogen atom has a pair of unshared electron pairs, which makes the electron cloud density distribution of the pyridine ring uneven, and the electrophilic substitution activity is different from that of benzene. Usually, the electron cloud density on the pyridine ring is relatively low, the electrophilic substitution reaction is more difficult than that of benzene, and the reaction check point is mostly at the β-position (a position separated from the nitrogen atom by a carbon atom). However, under appropriate conditions, halogenation, nitration, sulfonation and other electrophilic substitution reactions can also occur.
In addition, the benzyl moiety of the compound, since the benzyl carbocation is relatively stable due to the conjugation of the benzene ring, so that the hydrogen atom on the benzyl group has a certain activity, and the substitution reaction can occur under appropriate conditions, such as with halogen under the action of light or initiator.
In short ，“α - ( 4-cyanobenzyl) -2-pyridyl acetic acid "Because of the carboxyl group, cyano group, pyridyl ring and benzyl group, the chemical properties are rich and diverse, and it has important application potential in organic synthesis and other fields.

To prepare α - (4-methoxyphenyl) -2-butanone, the common synthesis methods are as follows:
First, ethyl acetoacetate is used as the starting material. Ethyl acetoacetate is first reacted with halogenated hydrocarbons to introduce 4-methoxyphenylalkyl groups. This reaction needs to be carried out under alkaline conditions. The base can take away the hydrogen of ethylene acetoacetate, generate carbon negative ions, and then undergo nucleophilic substitution with halogenated hydrocarbons. Subsequently, the obtained product is hydrolyzed and decarboxylated. During hydrolysis, the ester group is converted to a carboxyl group, and then decarboxylated by heating, and the target product α - (4-methoxyphenyl) -2-butanone can be obtained. The steps of this method are relatively clear, and the raw materials are relatively easy to obtain.
Second, the diethyl malonate method is used. Diethyl malonate is in an alkaline environment, and its methylene hydrogen is captured by the base to generate carbon negative ions, which are nucleophilic substitutions with halogenated hydrocarbons containing 4-methoxyphenyl groups. Subsequent hydrolysis and acidification to obtain malonic acid derivatives, and then heating decarboxylation to obtain the target compound. Diethyl malonate has high activity, relatively mild reaction conditions, and the yield is also considerable.
Third, it can be started from anisole and acetylacetone. First, the phenyl ether is acylated with the acylating reagent by Fu-gram, and the acetyl group is introduced on the phenyl ring. Then, the active methylene of acetylacetone is used to condensate with the above acylation products under the action of an alkaline catalyst to construct the carbon skeleton of the target product. This way cleverly uses the characteristics of phenyl ether and acetylacetone to achieve synthesis through reasonable steps.
Fourth, through the Grignard reagent method. The Grignard reagent is prepared by 4-methoxy halobenzene, and then reacted with butanone derivatives. 4-methoxyphenyl can be introduced into the butanone structure to form alpha - (4-methoxyphenyl) -2-butanone. This method requires attention to the strict control of the preparation and reaction conditions of Grignard reagents, and the anhydrous and anaerobic environment is crucial.

Eh! Fufu alpha - (4 -hydroxybenzyl) -2 -pyridinecarbonamide is widely used in the field of medicine.
It can be used for the diagnosis of diseases. Gein alpha - (4 -hydroxybenzyl) -2 -pyridinecarbonamide has unique chemical structures and properties, which can be combined with specific biomolecules in the body. In some diseases, there will be abnormalities in the type, quantity or distribution of biomolecules in the body. This compound can be specifically combined with these abnormal biomolecules, and with the help of specific detection methods, such as fluorescence detection, radioactivity detection, etc., to clearly display the status of biomolecules, so as to help doctors accurately diagnose diseases, such as certain tumor diseases. The combination of this compound with tumor-related markers can be used to achieve early and accurate diagnosis.
Furthermore, in the field of drug development, α - (4-hydroxybenzyl) -2-pyridineformamide also has important applications. Due to its unique structure, it can be used as a lead compound. Drug developers can modify and optimize their structures to design and synthesize a series of new drugs with better pharmacological activity and lower toxic and side effects. By making reasonable changes to each part of its structure, adjusting the affinity between the drug and the target, the metabolic characteristics of the drug, etc., and then developing specific drugs for specific diseases, such as cardiovascular diseases, neurological diseases, etc.
In addition, in terms of drug carriers, α - (4-hydroxybenzyl) -2-pyriformamide can also play a role. It can be modified and attached to some drug carrier materials, and by virtue of its affinity to specific cells or tissues, the drug carrier can be guided to target the lesion accurately. In this way, the concentration of the drug at the lesion site can be increased, the therapeutic effect can be enhanced, and the damage to normal tissues can be reduced. For example, in targeted tumor therapy, the drug can be accurately applied to tumor cells to improve the treatment efficiency.

Wen Jun's question is about the market price of alpha - (4-cyanobenzyl) -2-acetyl ethyl ester. This matter is related to commercial affairs, but if you want to clarify its price, you need to examine many situations in detail.
The price in the husband city is not fixed and does not change, and often moves with various factors. First look at the situation of supply and demand. If there are many applicants for this product, and there are few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price will decline. Then look at the difficulty of its production. If its preparation requires complicated techniques and rare materials, it will be high and the price will rise; if the production method is simple and the raw materials are widely available, the price will be low.
And the trend of market competition also affects its price. There are many competitors in the industry, competing for customers to sell, or to win the market, to reduce the price; if there is a single company, there is no semicolon, it has the power to set the price, and the price can be determined from the heart.
And time and place, the price also has an impact. Different times, the need to use this thing may vary; different places, the situation of production and sales is also different, and the price changes accordingly.
It is rare to know the details of this thing, such as the output of the place of origin, the field of demand, and the state of competition, so it is difficult to determine its price. To get the actual price, when you enter the cities, visit the merchants, and consider the newspaper quotes, you can understand the general idea. The sea of commerce changes, and only by careful investigation can we know the true meaning of its price.

I think what you are asking is about the manufacturer of alpha - (4-cyanobenzyl) -2-acetyl to it. However, it is difficult to find relevant records in "Tiangong Kaiwu". The author of "Tiangong Kaiwu", written in Chongzhen ten years in the Ming Dynasty, was written by Song Yingxing, detailing ancient Chinese agricultural and handicraft production technologies, such as grain processing, textiles, salt making, smelting, boat and car making, but does not involve the manufacturer information of these chemical compounds.
Today, chemicals such as alpha - (4-cyanobenzyl) -2-acetyl are mostly produced in modern chemical industry. Such manufacturers are distributed all over the place, often concentrated in the developed chemical industry. To know the details, you can use modern information channels, such as chemical product trading platforms, professional chemical information websites, etc., which have introductions to relevant manufacturers, or you can consult people in the chemical industry, who may be able to provide clues. However, "Tiangong Kaiwu" is limited by the times and cannot provide an answer to this question. Although it is a treasure of ancient Chinese science and technology and records many exquisite skills, the chemical industry is not what it used to be. Many new substances and new processes continue to emerge, which cannot be covered by ancient books.