acide 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylique

The elucidation of the chemical structure of the acid 5-bromo-1H-pyrrolido [2,3-b] pyridine-3-carboxylic acid is of great importance in the field of organic chemistry. The structure of this compound contains a unique pyrrolido-pyridine parent nucleus, on which bromine atoms are cleverly connected to carboxyl groups.
The skeleton of pyrrolido-pyridine is formed by fusing pyrrole rings and pyridine rings. The fusion of the two gives the molecule a unique electron cloud distribution and spatial configuration. The introduction of the 5-position bromine atom significantly affects the electronic properties and spatial resistance of the molecule. Bromine atoms have a large electronegativity and obvious electron-withdrawing effect, which decreases the density of the surrounding electron cloud, which in turn affects the reactivity and physical properties of the molecule.
As for the carboxyl group at the 3 position, it is a strong polar functional group, which not only enhances the hydrophilicity of the molecule, but also plays a key role in many chemical reactions, and can participate in various reactions such as esterification and amidation. The overall chemical structure of this acid, due to the synergistic effect of its various parts, shows unique chemical and physical properties. It has potential application value in many fields such as pharmaceutical chemistry and materials science, and is a structural system worthy of in-depth investigation.

5-Bromo-1H-pyrrolido [2,3-b] pyridine-3-carboxylic acid, this is an organic compound. It has a wide range of uses and is of great value in many fields.
In the field of medicinal chemistry, it is often a key intermediate. Through chemical reactions, it can be combined with other compounds to create drug molecules with specific biological activities. For example, in the development of some innovative drugs targeting specific disease targets, this compound can be ingeniously chemically modified to construct a drug structure that can precisely act on proteins or receptors related to pathogenic mechanisms, bringing new hope and avenues for the treatment of diseases.
also has a place in the field of materials science. Due to its unique molecular structure, it may be able to participate in the construction of new organic materials. For example, it can be used as a basic unit for the construction of materials with special optical and electrical properties. Through rational design of composites with other materials, it is expected to prepare materials that demonstrate excellent performance in optoelectronic devices, such as organic Light Emitting Diodes (OLEDs), solar cells, and other fields, and promote the development and innovation of related technologies.
In addition, it is also an important research object in the study of organic synthetic chemistry. Chemists use it as a starting material to explore novel synthesis routes and reaction mechanisms, expand the boundaries of organic synthetic chemistry, and lay the foundation for the synthesis of more complex and unique organic compounds, contributing to the continuous progress and innovation in the field of organic chemistry.

The synthesis of acide 5-bromo-1H-pyrrolo [2,3-b] pyrrolo [2,3-b] pyridine-3-carboxylique is a way to explore the creation of this compound in the field of chemistry. The following are common synthetic methods, described in ancient Chinese.
First, it can be initiated by a suitable pyridine derivative. First, take a pyridine containing a suitable substituent, and introduce a bromine atom at a specific position through a halogenation reaction. This halogenation step requires careful selection of halogenating reagents, such as bromine or specific brominating agents, and control of reaction conditions, such as temperature, solvent, and catalyst use. Too high or too low temperature may affect the location and yield of the bromine atoms introduced. After the bromine atoms are successfully introduced, the pyrrole ring is constructed. This process is often aided by specific organic synthesis reactions, such as cyclization reactions. Reagents containing appropriate functional groups can be used to promote intramolecular cyclization under suitable basic or acidic conditions, thereby forming a pyrrolido [2,3-b] pyridine skeleton. Finally, carboxyl groups are introduced at the third position of the pyridine ring through carboxylation reactions. There are many carboxylation methods, and suitable carboxylation reagents can be selected, such as the combination of carbon dioxide and organometallic reagents, or other specific carboxylation pathways, so as to obtain 5-bromo-1H-pyrrolido [2,3-b] pyridine-3-carboxylic acid.
Second, pyrrole derivatives are also used as starting materials. First, pyrrole is modified to introduce pyridine-related structural fragments. This process requires careful design of the reaction route, and the pyridine ring is gradually constructed through multi-step reactions. For example, using the activity check point of pyrrole, nucleophilic substitution or electrophilic substitution reaction occurs with reagents containing pyridine structural units. After constructing the pyridine ring, bromine atoms are introduced at suitable positions, and the method is similar to the above. Finally, the carboxylation step is also used to introduce carboxyl groups at the target position to achieve the synthesis of 5-bromo-1H-pyrrolido [2,3-b] pyridine-3-carboxylic acid.
When synthesizing this compound, every step of the reaction needs to be carefully controlled, from the purity of the raw material, the precise adjustment of the reaction conditions, to the separation and purification of the intermediate, all of which are related to the quality and yield of the final product. A little carelessness may cause the reaction to deviate from the expected path, or generate by-products, which affect the acquisition of the target compound.

5-Bromo-1H-pyrrolido [2,3-b] pyridine-3-carboxylic acid (5-bromo-1H-pyrrolo [2,3-b] pyridine-3-carboxylic acid) is an organic compound. Its physical and chemical properties are as follows:
###1. Physical properties
1. ** Appearance **: Usually in solid form, due to differences in preparation and purity, the appearance may be white to light yellow powder and crystalline. The powder is fine, and the crystals have a regular geometric shape. Under light irradiation or shine.
2. ** Melting point **: The melting point of this compound is about 260-265 ° C. When the melting point is reached, the solid molecule obtains enough energy to overcome the lattice energy, the lattice structure disintegrates, and turns into a liquid state. Accurate melting point is an important indicator for compound identification and purity judgment. The presence of impurities will reduce the melting point and widen the melting range.
3. ** Solubility **: Slightly soluble in water. Because its molecules contain hydrophobic aromatic ring structure, the interaction with water molecules is weak. But soluble in some organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF) and other polar organic solvents. In these solvents, compound molecules and solvent molecules are dissolved by electrostatic interaction, hydrogen bonding, etc.
####II. Chemical properties
1. ** Acidic **: The molecule contains a carboxyl group (-COOH) and is acidic. The hydroxy hydrogen in the carboxyl group can be dissociated, making the compound acidic in solution. It partially ionizes in water, releases hydrogen ions (H 🥰), and reacts with bases to form salts and water. For example, it reacts with sodium hydroxide (NaOH) to form 5-bromo-1H-pyrrolido [2,3-b] pyridine-3-carboxylate sodium and water.
2. ** Halogenation activity **: The bromine atom at the 5th position on the benzene ring has a certain reactivity. Under appropriate conditions, a nucleophilic substitution reaction can occur. The nucleophilic reagent attacks the bromine atom to connect to the carbon atom, and the bromine ion leaves to form a new carbon-nucleophil For example, in reaction with sodium alcohol, the bromine atom can be substituted by alkoxy groups to form corresponding ether derivatives.
3. ** Aromatic Ring Reactivity **: Pyrrolido-pyridine structural aromatic rings are aromatic and can undergo electrophilic substitution reactions. Due to the electronegativity of nitrogen atoms, the density distribution of aromatic ring electron clouds is uneven, and specific locations have different reactivity to electrophilic reagents. If under the action of appropriate catalysts, a Fu-gram acylation reaction can occur, and an acyl group is introduced on the aromatic ring.

I don't know the price of this "5-bromo-1H-pyrrolido [2,3-b] pyridine-3-carboxylic acid" in the market. This is a fine chemical substance, and its price often varies depending on quality, purity, supply, and purchase quantity.
If it is a high-purity scientific research grade, its preparation is difficult, and the materials used are also fine, and the price must be high, or it can be measured in hundreds of gold per gram. If you want to use it for high-end drug research and development, you need extremely high purity, and its price is high, and the price in milligrams is unknown.
If it is industrial grade, the purity is slightly lower, and it is suitable for general chemical synthesis. It can be purchased in batches depending on market supply and demand, ranging from hundreds of gold to thousands of gold per kilogram or. However, the market conditions are changing, and supply and demand compete, and the price also fluctuates.
To know the exact price, you can consult the chemical raw material supplier, reagent supplier, or visit the relevant chemical trading platform. Only by looking at the listed price and asking the negotiable range can you know the approximate price of the current product in the market.