7-Chloro-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthpyridine Carboxylic Acid Ethyl Ester

7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylic acid ethyl ester, this is a class of organic compounds with unique chemical properties.
Its appearance is often white to off-white crystalline powder, which is relatively stable at room temperature and pressure. However, it should be noted that its stability will be affected by environmental factors such as temperature, humidity and light. Excessive temperature or decomposition, high humidity can cause moisture absorption, light or accelerate some chemical reactions.
In terms of solubility, the compound exhibits some solubility in organic solvents such as ethanol and acetone, but poor solubility in water. This property is of great significance in the field of organic synthesis and drug development. During synthesis, appropriate reaction solvents can be selected according to their solubility to promote the smooth progress of the reaction. In drug development, solubility is closely related to the absorption, distribution, metabolism and excretion of drugs, which has a profound impact on the design and efficacy of drug formulations.
7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylate ethyl ester contains several special functional groups, such as chlorine atom, fluorine atom, cyclopropyl, carboxylethyl ester, and naphthidine ring structure. These functional groups give it a variety of chemical reactivity. Chlorine atoms and fluorine atoms can participate in nucleophilic substitution reactions due to electronegativity differences, creating conditions for the introduction of other functional groups; cyclopropyl structure has unique tension, which can enhance molecular stability and affect reaction selectivity; carboxyl ethyl esters can undergo hydrolysis, esterification and other reactions, which are key to the structural modification and property regulation of compounds; naphthalidine ring provides a rigid planar structure for the whole molecule, which has a significant impact on its physicochemical properties and biological activities.
In the field of organic synthesis, this compound is often used as a key intermediate to construct more complex organic molecular structures. Due to its special functional group combination, it can achieve structural modification and functionalization through various chemical reactions, laying the foundation for the synthesis of new drugs, pesticides and materials. In the process of drug development, studies have shown that it has inhibitory activity against specific microorganisms, or provides direction for the development of new antibacterial drugs. Through structural modification and optimization, it is expected to improve antibacterial effect, reduce toxic and side effects, and develop more efficient and safe antibacterial drugs.

The preparation method of 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthalidine-3-carboxylate ethyl ester has many different paths, which are described in detail below.
First, 2,3-dichloro-5-trifluoromethylpyridine is used as the starting material. First, it undergoes a nucleophilic substitution reaction with cyclopropylamine to obtain the corresponding substitution product. This step of the reaction needs to be carried out at a suitable temperature and in an alkaline environment. Potassium carbonate can be selected as the base to promote the reaction to generate the target product. Then, through hydrolysis reaction, the specific group on the pyridine ring is converted into a carboxyl group. Then the carboxyl group is converted into an acyl chloride with sulfoxide chloride and other reagents, and then the esterification reaction occurs with ethanol to obtain 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylic acid ethyl ester. This route step is relatively clear, and the raw materials are relatively easy to obtain, but some reaction conditions need to be carefully regulated.
Second, 6-fluoro-7-chloro-1,4-dihydro-4-oxo-1,8-naphthidine-3-carboxylic acid is used as raw material. First, it is esterified. Ethanol and concentrated sulfuric acid can be selected as catalysts, heated and refluxed to form an ester group with the carboxyl group and ethanol. Then, under basic conditions, with cyclopropyl halide, such as cyclopropyl bromide, and potassium iodide as catalyst, nucleophilic substitution occurs, and cyclopropyl is introduced into the naphthidine ring at the 1 position to obtain the target product. The esterification reaction in this path is relatively conventional, but the introduction of cyclopropyl groups requires attention to the reaction selectivity and side reactions.
Third, other similar structural compounds are also used as starters and converted through multi-step reactions. For example, the structure of naphthidine ring is constructed first, and then chlorine, fluorine, cyclopropyl and ethyl ester groups are introduced in sequence. Although this method has complicated steps, it has unique requirements for reaction conditions and reagents. If it can be precisely controlled, high yield and purity products can also be obtained. Each preparation method has its own advantages and disadvantages. According to actual needs, factors such as raw material cost, reaction conditions, product purity and yield should be considered, and the appropriate one should be selected.

7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylic acid ethyl ester, which is useful in the synthesis of medicine, is the key intermediate for the preparation of quinolone antibacterial drugs.
Quinolones antibacterial drugs have strong antibacterial activity and a wide range of antibacterial spectrum. They are widely used in clinical medical fields, such as the treatment of respiratory tract infections, urinary tract infections, intestinal infections and many other diseases, with good curative effect. 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylic acid ethyl ester can react with other reagents by virtue of its specific chemical structure in the synthesis process of these drugs, and then build a complete quinolone parent structure, which determines the antibacterial properties and pharmacological properties of the final product.
In addition, within the research scope of organic synthetic chemistry, 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylate ethyl ester is often used as a model compound to explore new synthesis methods and reaction mechanisms, and to promote the continuous development of organic synthetic chemistry theory and technology.

I don't know what the price range of 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylic acid ethyl ester is in the market. However, if you want to know its price, you can check it in detail on various chemical raw material trading platforms. Looking at the changes in the price of chemical products in the past, they often fluctuate due to raw materials, supply and demand, process, etc. If the raw materials of this compound are scarce, or the preparation process is complicated, the price may be high; if the raw materials are easily available, and the preparation is convenient, and the market supply is large and the demand is flat, the price may be easy. You can inquire about the price of this compound on professional platforms such as Gade Chemical Network and Mobell Chemical Network. Or contact chemical raw material suppliers and ask for their latest quotations, so that they can get a more accurate price range in the current market.

7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylic acid ethyl ester, which is related to safety and cannot be ignored. Its safety properties are intertwined by many factors.
From a chemical structure point of view, the compound contains halogen atoms such as chlorine and fluorine, which are quite active in chemical reactivity. The existence of halogen atoms can change the polarity of molecules, which in turn affects their physical and chemical properties. Change in polarity, or cause its solubility to be different from that of normal matter, and dissolve differently in different solvents. This is related to whether it can be evenly dispersed and stable during storage and use. If it is not handled properly, there may be a risk of precipitation and precipitation, which will affect its efficiency and even cause safety hazards.
Furthermore, although the cyclopropyl group contained in the molecule has a unique spatial structure and enhances molecular stability, it will also affect the reaction path and rate with other substances due to spatial hindrance. If a chemical reaction is involved in the production or use process, the spatial structure or reaction is difficult to proceed as expected, or unexpected by-products are generated, and some by-products may be toxic, corrosive and other hazards, threatening the safety of operators and the environment.
The carbonyl group (4-oxo) it contains, as a class of active functional groups, can participate in a variety of chemical reactions, such as nucleophilic addition. Although this reactive activity brings convenience to its synthesis in some processes, if it is not well controlled, reacts under unexpected conditions, or causes material properties to mutate, such as polymerization, decomposition, etc., it not only destroys the original material structure and function, but also releases a lot of energy during the polymerization or decomposition process, causing serious safety accidents such as fires and explosions.
In addition, the behavior of such compounds in the environment also needs to be considered. Its degradation rate and degradation products in the natural environment are all related to ecological safety. If the degradation is slow, it remains in the environment for a long time, or is enriched through the food chain, it poses a potential threat to biological and even human health. If the degradation products are toxic or biologically active, they will also change the chemical composition of the environment and affect the ecological balance.
In the industrial production process, every step from raw material storage, reaction operation to product refining needs to be strictly controlled. If the raw materials are improperly stored, they may contact each other or cause dangerous reactions. During the reaction process, slight deviations in parameters such as temperature, pressure, and reaction time may affect the quality and safety of the product. When the product is refined, if the impurities are not removed, it will also pose a threat to the safety of subsequent use.
In conclusion, the safety of 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthidine-3-carboxylate ethyl ester requires comprehensive consideration from various aspects such as chemical structure, reaction characteristics, environmental behavior and production process, and careful treatment to ensure that it does not cause safety problems during application.