6 Trifluoromethylpyridine 2 Carboxylic Acid
pyridine pyrrole pyrazine piperidine piperazine

6-Trifluoromethylpyridine-2-carboxylic acid

    Specifications

    HS Code

    470501

    Chemical Formula C7H4F3NO2
    Molar Mass 191.107 g/mol
    Appearance White to off - white solid
    Melting Point 163 - 165 °C
    Solubility In Water Slightly soluble
    Solubility In Organic Solvents Soluble in some polar organic solvents like DMSO, DMF
    Pka Around 2.8 (approximate value for the carboxylic acid group)
    Odor Odorless or very faint odor

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    General Information
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    Frequently Asked Questions

    As a leading 6-Trifluoromethylpyridine-2-carboxylic acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of 6-trifluoromethylpyridine-2-carboxylic acid?
    The chemical properties of triethylaminopropyltrimethoxysilane-2-carboxylic acid are particularly important and are related to many chemical and material applications.
    This compound has amphoteric characteristics. As far as its acidic end is concerned, it is acidic because it contains a carboxyl group (-COOH). The oxygen atom in the carboxyl group is very electronegative, which makes the hydrogen atom easily dissociated, thus showing acidity. It can neutralize with bases, such as when it encounters sodium hydroxide (NaOH), the hydrogen of the carboxyl group binds to the hydroxide group to form water, and the carboxyl group becomes a carboxylate. The equation for this reaction is as follows: R - COOH + NaOH → R - COONa + H2O O (R stands for triethylaminopropyl trimethoxysilane group).
    Its basic end has triethylamino (-N (CH ² CH). Nitrogen atoms have solitary pairs of electrons, can accept protons, and are basic. In aqueous solution, it can combine with hydrogen ions in water to form positive-charged ammonium ions. In the case of hydrochloric acid (HCl), triethylamino will bind to hydrogen ions, and the reaction formula is: R-N (CH ² CH 😉) 😉 + HCl → [R-NH (CH ³ CH 😉) 😉] 🥰 Cl.
    In addition, trimethoxysilyl (-Si (OCH 😉) 😉) is active. Hydrolysis is prone to occur in contact with water, and methoxy (-OCH 😉) is gradually replaced by hydroxyl (-OH) to form silanol (-Si (OH) 😉), and then a condensation and polymerization reaction can occur between the siloxanes to form a siloxane (-Si-O-Si-) network structure. This property makes the compound very useful in surface modification of materials and preparation of organic-inorganic hybrid materials. The hydrolysis reaction can be depicted as follows: R-Si (OCH) < unk > + 3H ² O → R-Si (OH) < unk > + 3CH < unk > OH, and the polycondensation reaction is: 2R - Si (OH) < unk > → R - Si - O - Si - R + 2H ² O. In this way, this compound has significant application value in many fields due to its unique chemical properties.
    What are the main uses of 6-trifluoromethylpyridine-2-carboxylic acid?
    Trimethoxybenzyl-2-carboxylic acid has a wide range of uses.
    This compound is quite useful in the field of medicine. First, it can be used as a key intermediate for drug synthesis. The creation of many drugs depends on its participation. With its unique chemical structure, it can introduce specific functional groups to assist in the construction of drug active ingredients. For example, some anti-cancer drugs with specific targeting properties need to be used as the basic raw material in the synthesis process. After a series of chemical reactions, the drug can be given the ability to precisely attack cancer cells, and can reduce damage to normal cells, improving drug efficacy and safety.
    In the field of materials science, it also has extraordinary performance. Can be used to prepare polymer materials with special properties. Using it as a monomer to participate in the polymerization reaction can make the obtained polymer material have unique optical and electrical properties. For example, the preparation of materials with special photoelectric conversion properties can be used in new solar cells to improve the photoelectric conversion efficiency of batteries and contribute to the development of the energy field.
    In the field of agriculture, it also has a place. It can be used as a raw material for the synthesis of new pesticides. After rational design and synthesis, the obtained pesticides have an efficient killing effect on specific pests, and compared with traditional pesticides, it has less pollution to the environment and better biodegradability. It can ensure the harvest of crops while maintaining the balance of the ecological environment.
    In the fragrance industry, triolemethoxyphenyl-2-carboxylic acid can also play a role. It can be used as an important component of synthesizing unique aromas and fragrances, adding a unique flavor to fragrances, enriching the types of fragrances, and satisfying people's pursuit of different fragrances.
    What are the synthesis methods of 6-trifluoromethylpyridine-2-carboxylic acid?
    To prepare 6-triethylaminohexyl-2-enoic acid, there are various methods. This is described in the text of "Tiangong Kaiwu".
    First, adipic anhydride and triethylamine are used as starting materials. First, the adipic anhydride is placed in the kettle, slowly heated to melt, and then the triethylamine is injected dropwise by dropwise method. During this process, the intermolecular interaction, the anhydride group and the amino group gradually form new bonds to obtain the desired enoic acid. After the reaction is completed, the product is purified by distillation, extraction, etc. to remove its impurities, and a relatively pure 6-triethylaminohexyl-2-enoic acid can be obtained.
    Second, 6-halogenated hexanoic acid and triethylamine can be used as raw materials. First take 6-halogenated hexanoic acid and dissolve it in a suitable solvent, such as ethanol or acetone. Then add triethylamine slowly. The halogen atom of halogenated hexanoic acid interacts with the nitrogen atom of triethylamine, and the halogen atom leaves to form a carbon-nitrogen bond, gradually forming 6-triethylaminohexanoic acid. However, at this time, the product may not be pure and needs to be refined During recrystallization, an appropriate solvent is selected to dissolve the product, and then the temperature is lowered to allow the crystallization to precipitate out, and the impurities are left in the mother liquor to obtain a pure product. Column chromatography uses silica gel as a filler to separate the products and impurities by using the difference in distribution coefficients between the stationary phase and the mobile phase.
    Third, it can also be prepared by ester exchange reaction between hexenoate and triethylamine. Place hexenoate and triethylamine in a reactor, add an appropriate amount of catalyst, such as an organotin compound. Heat and stir to make the two fully contact and react. The ester group is exchanged with triethylamine to form 6-triethylaminohexyl-2-enoic acid. At the end of the reaction, in addition to the catalyst, the unreacted raw materials and by-products are distilled under reduced pressure to obtain the target product. This method has its own advantages and disadvantages, and needs to be used according to actual needs.
    What is the price of 6-trifluoromethylpyridine-2-carboxylic acid in the market?
    Since modern times, the market has been in circulation, and the price of goods has changed from time to time. As for the price of triethylbenzyl ammonium chloride-2-carboxylate in the market, it also rises and falls with various factors.
    This salt has a wide range of uses and is used in the chemical and pharmaceutical industries. Its price is determined primarily by the situation of supply and demand. If various industries are booming, and there are many people who use it, and the demand exceeds the supply, the price will rise; if the market is sluggish, the demand is few, and the supply exceeds the demand, the price will be depressed.
    Furthermore, its price is also related to the price of raw materials. The preparation of triethylbenzyl ammonium chloride-2-carboxylate depends on various raw materials. If the price of raw materials is high, the cost of the system will also be high, and the price of the market will naturally rise; if the price of raw materials falls, the cost will decrease, and the price may also decline.
    The difficulty of the process is also a major reason. If the technique of making this salt is difficult, requires exquisite craftsmanship and financial resources, the price will be high; if the process is simple and easy to prepare, the price may be close to the people.
    The competition in the re-existence of the market also affects its price. If the merchants who produce this salt compete for profit, they are the ones who occupy the market share, or have to reduce the price in order to sell; if the producers are few and almost monopolized, the price may be high.
    As for the present, the price varies from city to city, depending on time and place. In bustling commercial ports, logistics is convenient, supply and demand can often be balanced, and the price may be stable; in remote places, transshipment is difficult, or the price may vary. If you want to know the exact price, you must consult the merchants of the cities and the brokers of the industry before you can get it.
    What are the manufacturers of 6-trifluoromethylpyridine-2-carboxylic acid?
    There are various manufacturers of 6-Sanxiang methyl pyridine-2-carboxylic acid, among which the well-known one is Hunan Jianhongda Chemical Co., Ltd. This company has been immersed in the field of chemical synthesis for many years and has a profound background. It has a complete and mature process for the production of Sanxiang methyl pyridine-2-carboxylic acid. From the selection of raw materials, to the control of synthesis steps, to the quality inspection of finished products, it is rigorous and orderly, and strives to produce high-quality products.
    Furthermore, Jiangsu Yonghua Fine Chemicals Co., Ltd. is also a leader in the industry. Its company pays attention to technological research and development and innovation, and continuously improves the production process to improve product quality. In the manufacture of Sanxiang methyl pyridine-2-carboxylic acid, with advanced equipment and exquisite skills, the product has high purity and stable performance, and is favored by many customers in the market.
    Shandong Jincheng Pharmaceutical Group joint stock company cannot be ignored. It has made a lot of achievements in the field of medicine and fine chemicals. In the production of Sanxiang methyl pyridine-2-carboxylic acid, relying on strong R & D strength and production scale advantages, the products produced are not only supplied to the domestic market, but also exported to overseas places, and also occupy a place in the international market.
    In addition, Zhejiang Yangfan New Materials joint stock company also has unique features in the production of Sanxiang methyl pyridine-2-carboxylic acid. The company takes green environmental protection as the concept, optimizes the production process, and pays attention to environmental protection when ensuring product quality. The products produced are of high quality and meet environmental protection requirements, and have unique advantages in market competition. These companies are all important manufacturers of Sanxiang methyl pyridine-2-carboxylic acid and play a key role in the development of the industry.