6 Trifluoromethyl Pyridine 3 Yl Methanol
pyridine pyrrole pyrazine piperidine piperazine

6-(trifluoromethyl)pyridine-3-yl methanol

    Specifications

    HS Code

    273879

    Chemical Formula C7H6F3NO
    Appearance Typically a colorless to light - yellow liquid or solid
    Solubility In Water Low solubility, organic - soluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, ethyl acetate
    Flash Point Estimated to be around 70 - 90°C
    Density Approximately 1.3 - 1.4 g/cm³
    Stability Stable under normal conditions, but may react with strong oxidizing agents

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    Frequently Asked Questions

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    What are the physical properties of 6- (trifluoromethyl) pyridine-3-ylmethanol?
    The physical properties of (Sanxiang methyl) alkane and 3-methyl ether are as follows:
    (Sanxiang methyl) alkane, which is a colorless liquid at room temperature and has a specific odor. Its boiling point is moderate, about [X] degrees Celsius, due to the force between molecules. The density is smaller than that of water, so it floats on the water surface. In terms of solubility, it is miscible in organic solvents such as ethanol and ether, but insoluble in water, which is caused by the difference between the polarity of its molecules and the polarity of water molecules.
    3-methyl ether, also a colorless liquid, has a slightly lighter odor than (Sanxiang methyl) alkane. The boiling point is about [Y] degrees Celsius, which is lower than that of (Sanxiang methyl) alkane, due to the difference in molecular structure and intermolecular forces. The density is also lower than that of water, and the solubility is similar to that of (Sanxiang methyl) alkane. It has good solubility in organic solvents, but is insoluble in water. Both are flammable. When burning, the flame is bright, and the combustion products are carbon dioxide and water due to the presence of carbon and hydrogen. And because it is an organic compound, it has active chemical properties and can participate in a variety of organic reactions, such as substitution reactions, addition reactions, etc., which are quite useful in the field of organic synthesis.
    What are the chemical properties of 6- (trifluoromethyl) pyridine-3-ylmethanol?
    The chemical properties of (Sanxiangmeidiyne) alkyne and (trimethylamine) are as follows:
    Sanxiangmeidiyne, which is unsaturated. There is a carbon-carbon triple bond in its molecule, which is active, so it can often perform addition reactions. It can be added with hydrogen, halogen, hydrogen halide, etc. When added with hydrogen, if an appropriate amount of hydrogen and a suitable catalyst are used, it can be gradually added to alkenes, and then added to alkanes; when it meets with halogens such as bromine water, the reddish brown of bromine water fades, and addition occurs to form bromine-containing derivatives; when added with hydrogen halide, according to the Markov rule, hydrogen is mostly attached to carbon containing more hydrogen to form halogenated hydrocarbons.
    Furthermore, Sanxiangmeidiyne is weakly acidic. Because of its triple bond carbon is sp hybridization, strong electronegativity makes alkynyl hydrogen acidic to a certain extent. It can react with strong bases such as sodium amide, and alkynyl hydrogen is replaced to form alkynides.
    And trimethylamine is an organic base. Because there are lone pairs of electrons on the nitrogen atom and can accept protons, it is basic. It can react with acids to form salts, such as with hydrochloric acid, to form trimethylamine hydrochloride. And trimethylamine can participate in nucleophilic substitution reactions, and the lone pairs of electrons of its nitrogen atom can attack electrophilic reagents such as halogenated hydrocarbons. The alkyl groups on nitrogen increase to form quaternary ammonium salts. Trimethylamine also has a special smell and is widely used in organic synthesis and chemical industry.
    These two have their own chemical properties and are of great significance in the reaction and synthesis of organic chemistry.
    What are the main uses of 6- (trifluoromethyl) pyridine-3-ylmethanol?
    6 - (Sanxiang methyl) to its - 3 - methyl ether, its main use covers many fields such as medicine and chemical industry.
    In the field of medicine, these substances are often the key intermediates for the synthesis of many special drugs. Doctors and pharmacists know that the synthesis of drugs is like a craftsman carving beautiful jade, and every step needs to be accurate. 6 - (Sanxiang methyl) to its - 3 - methyl ether can take advantage of its unique chemical properties to participate in complex reaction processes, paving the way for the creation of new drugs for the treatment of difficult diseases. Or in the synthesis of anti-cancer drugs, with its special structure, it helps to build key active parts, so that the drug can accurately target cancer cells, inhibit their growth and spread, and bring hope to patients.
    In the chemical industry, it is also an important raw material. The chemical industry, such as the grand loom, weaves colorful industrial scrolls with various raw materials. 6 - (Sanxiang methyl) to its - 3 - methyl ether can be used to synthesize polymer materials with excellent performance. These materials may have excellent heat resistance and corrosion resistance, and can be widely used in high-end fields such as aerospace and automobile manufacturing. For example, in an aerospace vehicle, components need to withstand extreme environments, and the components made of this material can ensure that the aircraft can soar safely in the sky.
    Or in the preparation of fine chemical products, 6- (Sanxiang methyl) to its -3-methyl ether can give unique properties to fragrances, coatings and other products. In the preparation of fragrances, it can add a different aroma level, making the fragrance more attractive and long-lasting; in the manufacture of paints, it can improve the adhesion and durability of paints, giving objects a strong and beautiful protective clothing. In a word, 6- (Sanxiang methyl) -3-methyl ether plays an indispensable role in many aspects such as medicine and chemical industry due to its unique chemical properties.
    What are the synthesis methods of 6- (trifluoromethyl) pyridine-3-ylmethanol?
    To prepare 6- (triethylamino) hexyl-3-enylaldehyde, the following methods can be used:
    First, 6-halogenated hexyl-3-enylaldehyde and triethylamine are used as raw materials, according to the principle of nucleophilic substitution. The halogen atom of halogenated hydrocarbons has good activity, and the nitrogen atom in triethylamine is rich in electrons and has nucleophilicity. When the two meet, the nitrogen atom attacks the α-carbon of halogenated hydrocarbons, and the halogen ion leaves to form the target product. For example, 6-bromohexyl-3-enylaldehyde and triethylamine, in an appropriate solvent (such as acetonitrile), add a base such as potassium carbonate to promote the reaction, and when the temperature is controlled and refluxed for a number of times, the product can be purified by extraction, column chromatography, etc.
    Second, by allylation reaction. With 3-enylaldehyde and allyl halide, accompanied by transition metal catalysts such as palladium and nickel, with the help of bases, carbon-carbon bonds can be formed. Such as 3-pentylenaldehyde and allyl bromide, tetrakis (triphenylphosphine) palladium as catalyst, cesium carbonate as base, in toluene solvent, heating reaction. After separation and purification, the allyl-containing product is obtained, and then condensed with ethylamine. After appropriate steps, 6- (triethylamino) hexyl-3-enylaldehyde can be prepared.
    Third, starting from the aldehyde and amine, it is constructed by Mannich reaction. Using 3-enylaldehyde, formaldehyde and diethylamine as raw materials, under acid catalysis, the α-hydrogen of aldehyde is activated and condensed with formaldehyde and diethylamine. For example, under acetic acid catalysis, the three react in ethanol solvent to obtain Mannich base intermediate, which is then converted into the target 6- (triethylamino) hexyl-3-enylaldehyde through elimination and rearrangement. This process requires fine regulation of reaction conditions to achieve ideal yield and purity.
    What are the precautions for 6- (trifluoromethyl) pyridine-3-ylmethanol in storage and transportation?
    The presence of trimethylheptyl ether, trimethylheptyl ether, is a chemical substance, and it is necessary to pay attention to the general situation when it is stored.
    The first priority is safety. These two are mostly flammable, so if it is not stored, it must be the source of ignition and the source of ignition, and the communication should be good. If it is dense in the air, it will gather together, and in case of an open flame, it may cause deflagration. And its evaporation and air mixing can form an explosive mixture. In operation, there must be no source of ignition.
    Furthermore, the container should be stored with caution. It is advisable to use corrosion-resistant materials, because the two or some materials will cause the reaction, rot the container, and cause leakage. Container density is also very important to prevent external pollution, pollution, and personal danger.
    In the process of transportation, it is necessary to prepare the appropriate fire-fighting equipment and emergency management of leakage. If a person is detained, he must be trained by the experts, and he must be familiar with the nature, hazards and emergency management methods of the object. On the way, avoid emergency and strong shocks to prevent the container from breaking.
    In addition, these two may have a certain toxicity. If it is not stored in the environment, it will keep the workers from being poisoned. If it is accidentally leaked, it will quickly isolate the pollution, restrict the entry and exit of people, and the emergency manager should wear protective equipment. Collect and clean up the leaks according to the correct method, and do not let them disperse wantonly.
    Therefore, trimethyltrimethylheptyl ether is required for safety in storage, container management, and environmental control to human prevention and emergency management, and all matters are carefully handled to ensure safety.