6-(propan-2-yloxy)pyridine-3-carboxylic acid

6 - (isobutoxy) alkyl-3 -carboxylate, its chemical structure is as follows:
In this compound, the number 6 position is connected with an alkyl group connected by an isobutoxy group. In the case of isobutoxy, it is a structure in which an oxygen group is connected to an isobutyl group. The structure of isobutyl is that a carbon atom is connected to three methyl groups and a methylene group. This methylene group is then connected to the oxygen group to form an isobutoxy group, which is connected to the 6 position of the whole molecule.
The carboxylate connected to the 3 position is formed by a carbonyl group connected to a hydroxyl group, that is, the -COOH structure. The carboxylate is the structure obtained after the hydrogen atom of the carboxyl group is replaced by a metal ion or other cation. The carboxylate structure is attached to the No. 3 position of the molecule, which has a great impact on the properties of the whole compound, such as solubility and chemical reactivity.
In the overall structure of this compound, the alkyl part provides a certain hydrophobicity, while the presence of the isobutoxy group may affect the spatial resistance and electron cloud distribution of the molecule, and the carboxylate part endows the molecule with certain hydrophilicity and reactivity. The interaction of each part jointly determines the physical and chemical properties of the compound and its performance in various chemical reactions and application scenarios. Compounds with this structure may have specific uses and research value in many fields such as organic synthesis, materials science, and medicinal chemistry.

6 - (propoxy) alkyl - 3 - acid, its physical properties are special.
This compound is often in the form of liquid or low-melt solid. Its melt boiling is due to the short alkyl group in the molecule and the branching situation. The alkyl group increases, the molecular force increases, and the melt boiling rises. The branching increases, the molecular distance is large, the force is weak, and the melting boiling decreases.
In terms of solubility, 6- (propoxy) alkyl - 3 - acid has a certain solubility in the solubility of alcohol and ketone. Because the alkyl group can be soluble, it forms a solution, and the propoxy group is also slightly soluble, which helps it to dissolve in this solution. However, in non-soluble solutions such as alkane, the solubility is low, and the molecular integrity is limited.
In terms of density, water is usually slightly smaller. This is due to the fact that the proportion of carbon components in the molecule is larger, and the density of carbon phase is smaller than that of water.
The outer layer is often colored to light color and transparent. Its viscosity is also the molecular phase. The viscosity increases, the branching is less, and the viscosity tends to increase, all due to the increase of molecular interactions.
In addition, this compound has certain properties, especially when added or often, small molecules are more likely to be damaged. This property needs to be paid attention to in the process of chemical reaction and fractionation. Therefore, the physicality of 6 - (propoxy) alkyl - 3 - acid is determined by its specific molecule, which is of great significance in the field of chemistry.

The main use of 6- (propoxy) to its 3-carboxyl group is in the field of research, chemical synthesis and materials science.
In the field of research, this compound is often used in the synthesis of molecules with specific physiological activities. Its properties can improve the bioavailability, targeting and efficacy of the compound. For example, in the research and synthesis of certain cardiovascular diseases, 6- (propoxy) to its 3-carboxyl group can be refined and modified, which can be used to produce specific receptors with high levels of strength. It is effective for the purpose of treating physiological properties.
For chemical synthesis, this is an important module for the synthesis of chemical molecules. Because of the carboxyl group and propoxy group it contains, it can be enriched and reversed, such as esterification and acetylation. With this method, it can be connected to different molecular frameworks to build a multi-component and complex compound system, which can be used for new materials and specialization.
In terms of material science, 6- (propoxy) to its 3-carboxyl group is also important. The specific space resistance of carboxyl groups and propoxy groups makes it possible to modify the surface of materials. For example, the introduction of this material into the polymer material can improve the surface properties of the material, such as surface properties and adsorption properties, and improve the performance of the material in the materials, adhesives, and other applications.

To prepare 6 - (isobutoxy) -3 - pyridinecarboxylic acid, the method of synthesis is as follows:
First, 3 - pyridinecarboxylic acid is used as the starting material. Shilling 3 - pyridinecarboxylic acid is combined with a suitable halogenating agent, such as thionyl chloride, to convert the carboxyl group into an acyl chloride group to obtain 3 - pyridinecarboxylic chloride. This reaction needs to be carried out under mild heating conditions in a suitable solvent, such as dichloromethane, to promote the reaction. Then, 3 - pyridinecarboxylic acid chloride is reacted with isobutanol in an alkaline environment. Triethylamine can be selected for basic reagents. When stirred at low temperature, the nucleophilic substitution reaction of acid chloride and alcohol occurs to generate 6- (isobutoxy) -3 -pyridinecarboxylate. Finally, the obtained ester is hydrolyzed under acid or base catalysis. If it is catalyzed by base, it is appropriate to use aqueous sodium hydroxide solution. When heated for reflux number, the ester group is broken. After acidification treatment, the target product 6- (isobutoxy) -3 -pyridinecarboxylic acid can be obtained.
Second, start from 3-hydroxypyridine. 3-hydroxypyridine reacts with isobutyl halides, such as isobutyl bromide, first under alkaline conditions. The base can be selected from potassium carbonate, heated in a suitable solvent, such as acetone, and refluxed. The hydroxyl group undergoes a nucleophilic substitution reaction with the halogenated hydrocarbon to generate 6- (isobutoxy) pyridine. Subsequently, with a suitable oxidant, such as potassium permanganate, under appropriate reaction conditions, the methyl group on the pyridine ring is oxidized to convert it into a carboxyl group, thereby obtaining 6- (isobutoxy) -3 -pyridine carboxylic acid. This process requires attention to control the reaction temperature and the amount of oxidant to prevent excessive oxidation of the pyridine ring.
Third, it can also be synthesized by the construction of pyridine derivatives. The pyridine ring is constructed by a multi-step reaction with a suitable nitrogen-containing heterocyclic precursor and a compound containing isobutoxy and carboxyl latent functional groups. If a 1,3-dicarbonyl compound is reacted with an ammonia source under appropriate conditions to form a pyridine ring skeleton, and isobutoxy and carboxyl-related groups are introduced at the same time. After appropriate functional group conversion and modification, 6- (isobutoxy) -3-pyridine carboxylic acid can also be obtained. This approach is complicated and requires precise control of the reaction in each step to improve the yield and purity.

When storing and transporting 6 - (isobutoxy) alkyl-3 -carboxylic acid, many people should pay attention to it.
Although this agent is relatively stable, it is still necessary to avoid hot topics and open flames. Under high temperature, it may cause chemical reactions, or even the risk of explosion, so it is important to store it in a cool and ventilated warehouse, and the temperature and humidity should be controlled.
And because it may be corrosive, contact with the skin and eyes can cause injury. When storing and transporting, be sure to use a corrosion-resistant container, the packaging is tightly closed to prevent leakage. If there is any leakage, clean it up quickly, and dispose of the waste according to regulations to avoid polluting the environment.
When handling, also be careful. Pack light and unload lightly to avoid damage to the container. Operators wear protective clothing, protective gloves and goggles, and prepare emergency treatment equipment.
Furthermore, it should not be mixed with oxidants, alkalis and other substances. When the two meet, it is easy to react and lead to safety hazards. Different chemicals are classified and transported according to their nature to ensure safe storage and transportation.
In the storage and transportation records, it should not be sparse. Write down the warehousing time, quantity, batch, etc. in detail, so as to trace the source. If there is a problem, it can be quickly investigated and dealt with, and the whole process of 6 - (isobutoxy) alkyl - 3 - carboxylic acid storage and transportation is safe and secure.