6-PHENYLPYRIDINE-3-BORONIC ACID

6-Phenylpyridine-3-boronic acid, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to its unique chemical structure and reactivity, it can form a reaction with boron-carbon bonds to couple with halogenated aromatics or olefins under the catalysis of transition metals, such as Suzuki coupling reaction. This reaction is extremely important in the construction of carbon-carbon bonds, helping to synthesize a variety of complex organic molecular structures. In the field of medicinal chemistry, it can be used to create new drug molecules. Compounds with specific activities and properties can be obtained by precisely linking different structural fragments.
In the field of materials science, 6-phenylpyridine-3-boronic acid is also used. With the help of its participation in the reaction, organic materials with specific photoelectric properties can be synthesized, such as the luminescent materials used in the preparation of Light Emitting Diodes (LEDs). Through clever design and reaction, the materials are endowed with unique photophysical properties to meet the needs of luminous efficiency and color in different scenarios.
In addition, in the process of research and development of new functional materials, 6-phenylpyridine-3-boronic acid uses its own characteristics or participates in the construction of polymers or supramolecular systems with special structures and functions, opening up new directions for the development of materials science and promoting progress in the field of high-tech.

6-Phenylpyridine-3-boronic acid, which is white to off-white solid. Its melting point is usually in a specific range, about 190-195 ° C. This melting point characteristic is of great significance for material identification and purity determination.
In terms of solubility, it has a certain solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide. In dichloromethane, by virtue of the interaction between its molecules and dichloromethane molecules, it can be partially dissolved, but the solubility is not very high; in N, N-dimethylformamide, due to the strong polarity of the solvent, it can form a relatively stable intermolecular force with 6-phenylpyridine-3-boronic acid, so the solubility is relatively better.
In water, because of its boric acid group, it can form hydrogen bonds with water molecules and has a certain water solubility, but due to the hydrophobicity of phenyl and pyridine groups, the overall water solubility is not very high.
In terms of stability, under normal environmental conditions, if properly stored, placed in a dry, cool and dark environment, it can maintain relatively stable. However, when encountering strong acids and bases, boric acid groups are prone to react, resulting in changes in molecular structure. When encountering strong oxidizing agents, because the molecules contain carbon-boron bonds and other oxidizable check points, they may be oxidized and the stability will be destroyed.
In addition, it has a certain coordination ability. Because boric acid groups can act as electron pair receptors, they can coordinate with ligands or metal ions containing power supply atoms such as nitrogen and oxygen. This property may have potential applications in the fields of materials science and catalysis.

To prepare 6-phenylpyridine-3-boronic acid, the method of organic synthesis is often followed. The method is multi-terminal, and a common method is given today.
The starting material is 6-bromophenylpyridine. This is a commonly used substance in organic synthesis and can be obtained in organic reagents. First, 6-bromophenylpyridine and magnesium chips are co-placed in an anhydrous ether reactor. This step requires extremely pure anhydrous ether, because if it contains impurities, it will disturb the reaction process. Fill the kettle with nitrogen to drain the air to prevent the raw material and magnesium chips from being oxidized by oxygen. Then, slowly raise the temperature to an appropriate temperature, so that the magnesium chips react with 6-bromophenylpyridine to form a Grignard reagent. This Grignard reagent is extremely active and decomposes in contact with water, so the operation must be cautious.
After obtaining the Grignard reagent, it is slowly dripped into the ether solution of trimethyl borate. The speed of this dropwise addition needs to be strictly controlled. If it is too fast, the reaction will be excessive and it will be difficult to control it. If it is too slow, it will take too much time and damage the efficiency. After the dropwise addition, maintain a certain temperature to make the two fully react. After this reaction, the intermediate product of borate esters is formed.
Then, the intermediate product is treated with an appropriate amount of dilute acid. The concentration and dosage of dilute acid are all related to the purity and yield of the product. After the action of dilute acid, borate ester is hydrolyzed to obtain 6-phenylpyridine-3-boronic acid. However, the product still contains impurities and needs to be further purified. The purification method of
can be used by column chromatography. Silica gel is used as the stationary phase, and an appropriate eluent is selected, such as the mixture of petroleum ether and ethyl acetate. According to the difference in polarity between the two, the ratio is controlled to separate the product from the impurities. After column chromatography separation, the eluent containing the pure product is collected, and the solvent is evaporated to obtain pure 6-phenylpyridine-3-boronic acid. During the entire synthesis process, each step requires fine operation, and strict control of reaction conditions such as temperature, time, and material ratio is required to obtain products with higher yield and purity.

6-Phenylpyridine-3-boronic acid is a commonly used reagent in organic synthesis. When storing and transporting, pay attention to many matters to ensure its quality.
First words storage. This product should be placed in a dry and cool place. The cover is quite sensitive to humidity. If it is in a humid place or in contact with water vapor, it is easy to cause hydrolysis, damage its chemical structure, and then lose its activity. And the cool environment can slow down the natural degradation that may occur. Due to high temperature, it often accelerates chemical reactions and causes them to deteriorate. The storage place should also be protected from direct light, light irradiation or photochemical reactions to change the properties of the compound.
Furthermore, it needs to be sealed and stored. The first seal can prevent moisture from entering, and the second can prevent contact with oxygen in the air. Oxygen may cause oxidation, which affects its purity and reactivity.
As for transportation, there are also many details. Appropriate packaging materials must be selected. Those with good moisture and shock resistance are preferred. The packaging is sturdy to avoid damage to the container due to bumps and collisions during transportation, resulting in drug leakage.
The transportation temperature also needs to be strictly controlled. According to its characteristics, it may need to be transported in the cold chain, or in a normal temperature but stable temperature zone. Do not make the temperature fluctuation range too large to prevent affecting the quality.
When transporting, pay attention to the isolation from other chemicals. 6-Phenylpyridine-3-boronic acid may have adverse reactions with certain substances, such as strong oxidants, strong bases, etc. Therefore, mixed packaging should be avoided during transportation to ensure transportation safety and drug quality.

I look at your question, but I am inquiring about the market price range of 6-phenylpyridine-3-boronic acid. Sadly, there is no record of this chemical in Tiangong Kaiwu, so it is difficult to answer according to its format. In today's world, the price of chemicals often changes for a variety of reasons, such as the price of raw materials, production methods, supply and demand conditions, differences in quality, and the amount of purchase.
Generally speaking, in the chemical reagent market, small quantities are purchased. If it is of ordinary purity, the price per gram may be between tens of yuan and hundreds of yuan. However, if the purchase quantity is very large, such as the kilogram level, due to the scale effect, the unit price may drop significantly, or fall to within tens of yuan per gram. If the purity requirements are extremely high, used for high-end scientific research or special industrial purposes, the price will also rise sharply, or more than 1,000 yuan per gram.
And different suppliers have different pricing. Imported brand reagents may be higher than domestic brands due to factors such as brand and quality control. If you want to know the exact price, you should consult the chemical reagent supplier, or check the relevant chemical product trading platform, in order to get the accurate price.