6-Phenylpyridine-2-carboxylic acid

6-Phenylpyridine-2-carboxylic acid, this is an organic compound. It has many unique chemical properties and is of great significance in the fields of organic synthesis and medicinal chemistry.
Looking at its structure, it contains phenyl and pyridine-2-carboxylic acid structural fragments. The phenyl group is an aromatic hydrocarbon group, which endows the compound with certain hydrophobicity and stability of the conjugate system; the pyridine ring is also an aromatic heterocycle, which is basic and can accept protons because of the solitary pair electrons of the nitrogen atom. The combination of the two makes the chemical activity and stability of the compound unique.
Acidity is one of the important chemical properties. Part of the carboxyl group of pyridine-2-carboxylic acid can ionize hydrogen ions and is aci In solution, depending on the pH value of the environment, it exists in the form of acid or carboxylate. The acidity is affected by the surrounding groups, and the phenyl electronic effect can change the acidity of the carboxyl group. When the phenyl group is powered, the acidity of the carboxyl group is slightly reduced; when the phenyl group absorbs electrons, the acidity of the carboxyl group is slightly increased.
In terms of nucleophilic substitution reaction, the nitrogen atom of the pyridine ring has a solitary pair of electrons, which shows a certain nucleophilicity and can react with the electrophilic reagent. Electrophilic substitution reactions can occur on the aromatic ring, such as halogenation, nitrification, sulfonation, etc. The conjugation system of phenyl and pyridine changes the density distribution of the aromatic ring electron cloud Usually, the electron cloud density on the pyridine ring is lower than that of the phenyl group, and the electrophilic substitution is more likely to occur at the higher electron cloud density position on the phenyl group.
In addition, it can participate in the esterification reaction. The carboxyl group and alcohol generate corresponding ester compounds under acid catalysis. This reaction is widely used in organic synthesis to prepare ester products with different functions. At the same time, due to the existence of a conjugate system, the compound has certain optical properties, such as fluorescence may be emitted under specific wavelength light irradiation, and may have potential applications in the field of optical materials.

6-Phenylpyridine-2-carboxylic acid, this is one of the organic compounds. Its physical properties are unique and of great value for investigation.
Looking at its appearance, it is mostly white to white solid powder under normal conditions, delicate and uniform, or visible in sunlight with a faint luster, as if hiding the mystery of nature.
When it comes to the melting point, it is about a specific range, and this value is of great significance for the identification and purification of this compound. When the temperature slowly rises to the vicinity of the melting point, its solid structure begins to quietly disintegrate, and the intermolecular forces are rearranged, gradually changing from solid to liquid, just like ice and snow melting under the warm sun, showing the wonderful process of material form transformation.
Solubility is also one of its important physical properties. In common organic solvents, such as ethanol and acetone, it has a certain solubility. In ethanol, with slight changes in temperature, the rate and degree of dissolution will vary. Moderate heating increases the movement of solvent molecules and collides with solute molecules more frequently, prompting more 6-phenylpyridine-2-carboxylic acid molecules to be uniformly dispersed in the ethanol system, forming a uniform and stable solution like stars merging into the vast night sky. However, the solubility in water is relatively limited, which is due to the influence of hydrophobic groups in its molecular structure. It is difficult to form effective interactions between water molecules and solute molecules, just like oil and water.
In addition, the density of this compound also has its specific value. Although it is not as significant as the density of metals, it is also an indispensable parameter for precise experimental operations and related theoretical research. Its density performance under different conditions reflects the changes in molecular stacking patterns and spacing, providing clues for in-depth understanding of its microstructure.
The physical properties of this compound are interrelated and together build up its unique physical properties, laying the foundation for subsequent chemical research, synthetic applications, etc. It is as important as a cornerstone for a tall building.

In the synthesis of 6-phenylpyridine-2-carboxylic acid, the following methods are commonly used.
One is to use pyridine-2-carboxylic acid as the starting material, through halogenation reaction, the halogen atom is introduced into the 6 position of the pyridine ring. Commonly used halogenating agents such as N-halogenated succinimide are carried out in the presence of suitable solvents and catalysts. The obtained halogenated pyridine-2-carboxylic acid is then coupled with phenylboronic acid through Suzuki reaction. Under the action of base and palladium catalyst, the reaction is heated in an organic solvent to obtain the target product 6-phenylpyridine-2-carboxylic acid. The steps of this path are relatively clear, the reaction conditions of each step are relatively easy to control, and the yields of halogenation and coupling reactions are usually considerable.
The second can be started from suitable pyridine derivatives, through the Fu-gram alkylation reaction, with phenyl halide or phenylation reagent, under the action of Lewis acid catalyst such as aluminum trichloride, the phenyl group is attached to a specific position of the pyridine ring, and then the side chain is converted into carboxyl group through oxidation step. However, the selectivity of the Fu-gram reaction region may be a challenge, and the substrate and reaction conditions need to be carefully selected to improve the selectivity of the target product.
In addition, acetophenone compounds and pyridine-2-formaldehyde are used as raw materials to form unsaturated intermediates through condensation reaction, and then a series of reactions such as oxidation and cyclization are used to construct pyridine rings and introduce carboxyl groups, and finally 6-phenylpyridine-2-carboxylic acid is obtained. Although this route is slightly complicated, the raw materials are widely sourced, and the reaction sequence and conditions are reasonably designed to achieve effective synthesis.
Each method has its own advantages and disadvantages. In actual synthesis, the choice needs to be weighed according to many factors such as raw material availability, cost, target product purity and yield.

6-Phenylpyridine-2-carboxylic acid, this compound has applications in many fields. In the field of medicinal chemistry, it can be used as a key intermediate to create drugs with specific biological activities. Due to its unique chemical structure, it can interact with specific targets in organisms or regulate physiological processes in organisms, promising to develop new drugs for specific diseases.
In the field of materials science, 6-phenylpyridine-2-carboxylic acid also has potential uses. It can be used to prepare materials with special properties, such as participating in the synthesis of coordination polymers. With its carboxyl group and pyridine ring, it can coordinate with metal ions to build a variety of coordination polymer materials. Such materials may have unique optical, electrical or adsorption properties, and may have applications in luminescent materials, sensor materials, etc.
Furthermore, in the field of organic synthetic chemistry, 6-phenylpyridine-2-carboxylic acid can be used as an important building block for organic synthesis. With its reactivity of phenyl, pyridine ring and carboxyl group, various organic reactions can be carried out to realize the construction of complex organic compounds, expand the structural diversity of organic compounds, and provide assistance for the development of organic synthetic chemistry.

6-Phenylpyridine-2-carboxylic acid, this is an organic compound. However, its market price is difficult to draw a conclusion. Due to many factors, its price is determined.
First, the cost of raw materials. The preparation of this compound requires specific raw materials. If the raw materials are scarce or difficult to obtain, the price must be high; conversely, if the raw materials are abundant, the price may be slightly reduced.
Second, the preparation process is simple. If the preparation requires exquisite and complex processes, the equipment and technology requirements are extremely high, the investment cost is also large, and the price is not cheap; if the process is relatively simple, the cost is reduced, and the price may be more accessible to the people.
Third, the market supply and demand. If the market demand for this compound is strong, but the supply is limited, according to the principle of supply and demand, the price will rise; if the demand is low and the supply is excessive, the price may decline.
Fourth, quality specifications. Different qualities and purity of 6-phenylpyridine-2-carboxylic acid, the price difference is also large. Those with high purity are mostly used in high-end fields, and the price is high; those with slightly lower purity have different uses and prices.
Looking at "Tiangong Kaiwu", although there is no price of this compound, it is related to the process, raw materials and production. Therefore, the price of 6-phenylpyridine-2-carboxylic acid does change due to the above numbers. To know the exact price, consult the chemical raw material supplier, or refer to the real-time quotation of the chemical product trading platform to get the accurate number.