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What is the chemical structure of 6- (Phenylmethyl) -5H-pyrrolo [3,4-b] pyridine-5,7 (6H) -dione?
6- (phenylmethyl) -5H-pyrrolido [3,4-b] pyridine-5,7 (6H) -dione, an organic compound. Its chemical structure is quite complex, composed of several atoms bonded in a specific way.
First look at its core structure, which is the skeleton of pyrrolido [3,4-b] pyridine. The pyrrole ring is cleverly fused with the pyridine ring to form a unique ring system. The pyrrole ring contains one nitrogen atom and four carbon atoms, which are aromatic. The delocalization of its π electron cloud gives the structure a certain stability. The pyridine ring also contains one nitrogen atom and five carbon atoms, which are also aromatic. The fused two rings make the electron cloud distribution of the whole system more special, which affects the physical and chemical properties of the compound.
On the basis of this core structure, there is a (phenylmethyl) group connected at 6 positions. The phenyl group is composed of six carbon atoms and consists of a benzene ring. It has a highly conjugated system. It has a planar structure and is electron-rich. It can interact with other molecules such as π-π stacking. The methyl group is connected to the phenyl group and then connected to the 6 position of the core skeleton. The introduction of this substituent changes the spatial configuration of the molecule and the electron cloud density distribution. < Br >
5,7 (6H) -dione moiety, that is, there is a carbonyl group (C = O) at the 5th and 7th positions. The carbonyl group has strong polarity, the oxygen atom in the carbon-oxygen double bond has high electronegativity, and the ability to attract electrons is strong, which makes the carbonyl carbon partially positively charged and vulnerable to nucleophilic attack, thus endowing the compound with rich chemical reactivity.
The structural characteristics of this compound make it potentially valuable in organic synthesis, medicinal chemistry and other fields. Due to its unique electronic structure and spatial configuration, it can be used as a lead compound to develop drugs with specific biological activities through structural modification and optimization, or to design novel organic synthesis intermediates to build more complex organic molecules.
What are the physical properties of 6- (Phenylmethyl) -5H-pyrrolo [3,4-b] pyridine-5,7 (6H) -dione
6 - (benzyl) -5H - pyrrolido [3,4 - b] pyridine-5,7 (6H) -dione, this is an organic compound. Its physical properties are unique, let me tell you one by one.
Looking at its appearance, under normal circumstances, it is mostly in a solid state. As for the color, it may be white to light yellow powder, delicate and uniform, just like the light snow that falls at the beginning of winter, and the fine sand that rises at the end of autumn.
Talking about the melting point, it is about a certain temperature range. This temperature range is slightly different due to slight differences in purity, but it is roughly around a certain value. It is just like the operation of a star. Although it fluctuates, it does not deviate from its orbit. This melting point property is of great significance in the identification and purification of this compound.
In terms of solubility, it also has characteristics in organic solvents. In organic solvents such as dichloromethane, N, N-dimethylformamide, it shows a certain solubility, as if fish enter water and can partially melt; in water, the solubility is poor, just like oil floating in water, immiscible. This difference in solubility provides an important basis for experimenters in the separation of compounds and the selection of reaction environments.
Furthermore, its density is also a key physical property. Although the specific value needs to be accurately measured, it can be determined that its density has a significant impact on the distribution and behavior of the compound in a specific system, just like boulders and light feathers, which settle and float differently in water.
In addition, the stability of the compound is also worthy of attention. Under normal temperature and humidity conditions, it can still maintain a relatively stable state; however, in case of extreme conditions such as high temperature, strong acid, and strong alkali, or in case of wind and rain, the structure may change and the properties will also change.
The above physical properties are all key elements for in-depth understanding of 6- (phenylmethyl) -5H-pyrrolido [3,4-b] pyridine-5,7 (6H) -dione, and lay the foundation for the exploration and application in many fields such as scientific research and production.
What is the main use of 6- (Phenylmethyl) -5H-pyrrolo [3,4-b] pyridine-5,7 (6H) -dione
6- (phenylmethyl) -5H-pyrrolido [3,4-b] pyridine-5,7 (6H) -dione, which is mostly used in the field of medicinal chemistry in today's world and is a key intermediate for the development of new drugs.
Guanfu Medicine is related to the health of all people, and this compound is quite useful in it. In the process of drug creation, it is often used as the basis for building complex drug molecules. Its unique structure can interact with many targets in the body, like a delicate key, which can unlock the lock of specific physiological mechanisms.
For example, in the field of anti-tumor drug research and development, scientists hope to obtain new anti-cancer drugs with high activity and low toxicity by modifying and modifying their structures. Because it can precisely act on specific targets of tumor cells, inhibit tumor cell proliferation and induce apoptosis, it is like a magic weapon, hitting the key of the disease.
For example, in the field of drug exploration for neurological diseases, 6- (phenylmethyl) -5H-pyrrolido [3,4-b] pyridine-5,7 (6H) -dione has also emerged. Or it can regulate the transmission of neurotransmitters, improve the function of nerve cells, and bring light to the treatment of stubborn diseases such as Parkinson's disease and Alzheimer's disease, just like a lamp of hope in the dark.
Furthermore, in the field of anti-infective drug research and development, this compound also has potential. Or it can interfere with the metabolic process of pathogens, block their growth and reproduction paths, and become a solid barrier against the invasion of pathogens.
What are the synthesis methods of 6- (Phenylmethyl) -5H-pyrrolo [3,4-b] pyridine-5,7 (6H) -dione
There are many approaches to the synthesis of 6- (phenyl) -5H-pyrrolido [3,4-b] pyridine-5,7 (6H) -dione.
First, this structure can be constructed through a multi-step organic reaction. The starting material or the pyridine derivative and pyrrole derivative with suitable substituents are selected. First, the pyridine derivative is reacted with appropriate reagents under specific reaction conditions, and a specific functional group is introduced on the pyridine ring to lay the foundation for subsequent reactions with pyrrole derivatives. For example, the nucleophilic substitution reaction of the pyridine derivative with the halogenated hydrocarbon is catalyzed by a base, and the benzyl group is introduced. Subsequently, the pyrrole derivative and the modified pyridine derivative undergo a condensation reaction under the action of a condensation agent to form the basic skeleton of pyrrole-pyridine. This process requires strict control of the reaction temperature, time and the proportion of reactants in order to improve the yield and purity.
Second, the synthesis strategy of transition metal catalysis can also be used. Complexes of transition metals such as palladium and copper are used as catalysts to promote the coupling reaction between different functional groups. For example, suitable halogenated pyridine derivatives and benzylboronic acid derivatives are selected, and Suzuki-Miyaura coupling reaction is carried out in the presence of palladium catalysts and ligands to efficiently introduce benzyl groups. After subsequent oxidation, cyclization and other reaction steps, the 5,7-dione structure was constructed. This method has the advantages of mild reaction conditions and high selectivity, but the catalyst cost is high, and the reaction conditions need to be carefully selected and optimized to reduce costs.
Third, you can also try to use natural products as starting materials for semi-synthesis. Some natural products containing pyridine or pyrrole structures in nature may be chemically modified to be converted into this target compound. First, the natural products are extracted and isolated to obtain high-purity starting materials. Then, according to the structural characteristics of the natural products, targeted modification routes are designed. For example, through selective oxidation, reduction, substitution and other reactions, the required functional groups are gradually introduced to finally synthesize 6- (phenyl) -5H-pyrrolido [3,4-b] pyridine-5,7 (6H) -dione. The advantage of this method is that the raw materials have a biological activity basis, or the final product has a unique biological activity, but the source of natural products is limited, and the separation and purification process is complicated.
6- (Phenylmethyl) -5H-pyrrolo [3,4-b] pyridine-5,7 (6H) -dione What are the precautions when storing and using
6 - (phenylmethyl) -5H - pyrrolido [3,4 - b] pyridine-5,7 (6H) -dione, this is a special organic compound. When storing and using, pay attention to many key matters.
First storage environment. It should be placed in a cool, dry and well-ventilated place. Because it may be sensitive to humidity and temperature, moisture can easily cause chemical reactions such as hydrolysis, which can damage the quality. Excessive temperature may also cause decomposition and other conditions, so it is necessary to ensure that the temperature and humidity of the storage are suitable.
Furthermore, it concerns its packaging. Packaging materials with good sealing performance should be used to prevent excessive contact with air. Due to the fact that certain chemical groups may be easily oxidized, sealed packaging can reduce contact with oxygen, thus prolonging its shelf life.
When using, it must be handled with caution. Because of its toxicity or irritation, it is necessary to take protective measures. When operating, wear appropriate protective equipment, such as gloves, protective glasses and masks, to prevent the substance from coming into contact with the skin, eyes or being inhaled into the body, causing harm to the human body.
And during use, follow strict operating procedures. Before and after use, the utensils used should be properly cleaned to prevent the residual substance from affecting subsequent experiments or production. At the same time, the waste generated during use must also be properly disposed of in accordance with relevant regulations, and must not be discarded at will to avoid pollution to the environment.
Only by paying attention to the above matters when storing and using this compound can we ensure that its quality is not damaged, and at the same time ensure the safety of users and the safety of the environment.