6 Oxa 1 6 Dihydropyridine 2 5 Dicarboxylic Acid
pyridine pyrrole pyrazine piperidine piperazine

6-oxa-1,6-dihydropyridine-2,5-dicarboxylic acid

    Specifications

    HS Code

    855922

    Name 6-oxa-1,6-dihydropyridine-2,5-dicarboxylic acid
    Molecular Formula C6H5NO5
    Molecular Weight 171.11
    Appearance Solid (predicted)
    Boiling Point 483.3°C at 760 mmHg (predicted)
    Melting Point 232 - 234 °C (lit.)
    Flash Point 246.1°C (predicted)
    Density 1.663 g/cm³ (predicted)
    Solubility Soluble in DMSO (Slightly), Methanol (Slightly)
    Pka 1.78±0.10 (Predicted)
    Logp -1.13 (Predicted)

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    General Information
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    Frequently Asked Questions

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    What is the chemical structure of 6-oxa-1,6-dihydropyridine-2,5-dicarboxylic acid?
    6-Oxa-1,6-dihydropyridine-2,5-dicarboxylic acid, the analysis of its chemical structure is related to the category of organic chemistry. In this compound name, "6-oxa" indicates that the oxygen atom in its structure is at position 6 and participates in the construction of heterocyclic rings. "1,6-dihydropyridine" means that this is a derivative of dihydropyridine. The 1st and 6th positions of the pyridine ring are dihydro states, that is, the double bond at a specific position on the pyridine ring is hydrogenated. And "2,5-dicarboxylic acid" explicitly states that there are carboxyl (-COOH) groups at the 2nd and 5th positions of the pyridine ring, respectively.
    According to the ancient saying, the structure of this compound is like a delicate structure. The oxygen atom is like a mortise and tenon, embedded in the six-position position, participating in the construction of the ring. The dihydropyridine part is like a ring that has undergone changes, and the double bonds of the 1st and 6th positions are changed due to hydrogenation. As for the carboxyl groups at the 2nd and 5th positions, they are like two branches born on the ring, each with its unique chemical properties. Its overall structure shows unique properties in the study of organic chemistry, or in the aspects of reactivity, chemical synthesis and biological activity due to the acidity of carboxyl groups, the characteristics of pyridine rings and dihydro states, providing various possibilities for the research of organic synthesis and medicinal chemistry.
    What are the common synthesis methods of 6-oxa-1,6-dihydropyridine-2,5-dicarboxylic acid?
    6-Oxa-1,6-dihydropyridine-2,5-dicarboxylic acid is a kind of organic compound. There are many common methods for synthesizing this compound.
    One of them can be prepared by heterocyclization reaction. The condensation reaction is carried out under suitable reaction conditions with appropriate carbonyl-containing compounds and nitrogenous and oxygen-containing nucleophiles. In this process, the carbonyl group interacts with the nucleophilic reagent, and after a multi-step reaction, the skeleton of the pyridine ring is constructed, and oxygen atoms and carboxyl groups are introduced at the same time. During the reaction, the reaction temperature, reaction time and the ratio of reactants need to be precisely adjusted to ensure that the reaction proceeds in the direction of generating the target product. < Br >
    Second, the synthesis path of transition metal catalysis is adopted. Transition metal catalysts have unique activity and selectivity in organic synthesis. Suitable transition metal catalysts, such as palladium and copper, can be selected with corresponding ligands to promote the coupling reaction of substrate molecules. By ingeniously designing the structure of the substrate molecules, they are gradually connected to form the structure of 6-oxa-1,6-dihydropyridine-2,5-dicarboxylic acid under the action of transition metal catalysts. The key to this method is to screen suitable catalysts and ligand combinations, and optimize the reaction conditions to improve the yield and selectivity of the reaction.
    Third, the cyclization rearrangement reaction is used as a strategy. Some precursor compounds with specific structures can undergo intra-molecular cyclization and rearrangement under appropriate reaction conditions to generate the target product. This process requires careful design of the structure of the precursor compound, using specific reaction reagents and conditions to initiate the rearrangement reaction, and accurately construct the structure of the target compound.
    All the above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider the specific situation, such as the availability of raw materials, the cost of the reaction, and the purity requirements of the product, and choose the best one to use.
    Where is 6-oxa-1,6-dihydropyridine-2,5-dicarboxylic acid used?
    6-Oxa-1,6-dihydropyridine-2,5-dicarboxylic acid, that is, 6-oxa-1,6-dihydropyridine-2,5-dicarboxylic acid, is useful in various fields.
    In the field of medicine, this compound shows unique potential. Due to its special chemical structure, it may be used as a lead compound to develop new drugs. Or it can be helpful for the treatment of specific diseases, such as certain inflammatory diseases, through the interaction of its structure with biological targets in the body, or it can regulate related biological processes to achieve therapeutic purposes.
    In the field of materials science, 6-oxa-1,6-dihydropyridine-2,5-dicarboxylic acid can also be used. It can participate in the synthesis of specific materials and endow materials with special properties. Or it can be used to prepare materials with specific optical and electrical properties, which are used in optical devices, electronic components, etc., to meet the needs of different fields for special properties of materials.
    Furthermore, in the field of organic synthesis, this acid is often used as a key intermediate. With its carboxyl group and heterocyclic structure, it can be combined with other organic molecules through various chemical reactions to form more complex organic compounds, providing an important starting material for organic synthesis chemists to assist in the synthesis of various organic molecules with specific functions and structures, and promoting the development of organic synthesis chemistry.
    What are the physical properties of 6-oxa-1,6-dihydropyridine-2,5-dicarboxylic acid?
    6 - oxa - 1,6 - dihydropyridine - 2,5 - dicarboxylic acid is an organic compound. Its physical properties are unique and have the following numbers.
    Looking at its morphology, under room temperature and pressure, it is mostly in a solid state, because of the intermolecular force. In the molecular structure, the specific atomic arrangement and chemical bond characteristics make the intermolecular interaction strong, which prompts it to exist in a solid state.
    When it comes to solubility, this compound may have a certain solubility in polar solvents such as water. The molecule contains polar groups such as carboxyl groups, which can form hydrogen bonds with water molecules. However, the solubility is also affected by other molecular parts. In organic solvents, its solubility may vary depending on the polarity and molecular structure of the solvent. For example, in polar organic solvents such as methanol and ethanol, the solubility may be relatively high, and its polarity is in line with the polarity of the compound, and it can be miscible through intermolecular forces.
    Its melting point is also an important physical property. Due to the stability of the molecular structure and the strength of the intermolecular forces, it is endowed with a specific melting point. The determination of the precise melting point requires professional experimental equipment and is carried out under rigorous experimental conditions. The level of melting point reflects the degree of bonding between molecules, and is also one of the key indicators for identifying this compound.
    As for the boiling point, it is also related to the intermolecular forces and molecular structure. Higher intermolecular forces require more energy to overcome, causing its boiling point to rise. The data of boiling point is of great significance for its phase change under specific temperature conditions and for applications in chemical, pharmaceutical and other fields.
    In addition, the color state of this compound, when pure, may be white to off-white, but if it contains impurities, the color state may change. This color state characteristic can be an important reference for the preliminary identification and purity judgment of compounds.
    What are the chemical properties of 6-oxa-1,6-dihydropyridine-2,5-dicarboxylic acid?
    6-Oxa-1,6-dihydropyridine-2,5-dicarboxylic acid, this is an organic compound with considerable characteristics. In terms of physical properties, it may be a crystalline solid under normal conditions, because it contains polar carboxyl groups, it may have a certain solubility in water, and the melting point of the interaction between carboxyl groups is within a specific range.
    In terms of chemical properties, carboxyl groups are acidic and can neutralize with bases to form corresponding carboxylic salts. In the case of alcohols, under suitable catalysts and conditions, esterification reactions can occur, and ester compounds can be derived. The heterocyclic structure of 6-oxa-1,6-dihydropyridine endows it with unique electronic properties or participates in various electrophilic or nucleophilic substitution reactions. The hydrogen atoms on the heterocyclic ring have different activities due to the electronic effects of surrounding atoms and can be replaced by other groups. This compound is used in the field of organic synthesis, or is often used as a key intermediate. With its carboxyl and heterocyclic properties, it participates in the construction of more complex organic molecular structures, laying the foundation for the creation of new drugs, functional materials, etc.