6 Nitro 1h Pyrrolo 2 3 B Pyridine
pyridine pyrrole pyrazine piperidine piperazine

6-NITRO-1H-PYRROLO[2,3-B]PYRIDINE

    Specifications

    HS Code

    840883

    Chemical Formula C7H5N3O2
    Molar Mass 163.134 g/mol
    Appearance Solid (usually powder)
    Solubility In Water Poor (organic compound, non - polar nature dominates)
    Solubility In Organic Solvents Soluble in common organic solvents like DMSO, DMF
    Uv Vis Absorption Absorption bands characteristic of aromatic and nitro groups, data need experimental determination

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    General Information
    Where to Buy 6-NITRO-1H-PYRROLO[2,3-B]PYRIDINE in China?
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    Frequently Asked Questions

    As a leading 6-NITRO-1H-PYRROLO[2,3-B]PYRIDINE supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 6-NITRO-1H-PYRROLO [2,3-B] PYRIDINE
    6 - NITRO - 1H - PYRROLO [2,3 - B] PYRIDINE is one of the organic compounds. Its main uses are quite extensive and play a crucial role in the field of medicinal chemistry.
    In this field, this compound is often a key intermediate for the synthesis of many drugs. Due to its unique chemical structure, it can be combined with other chemical groups through various chemical reactions to construct drug molecules with complex structures and specific pharmacological activities. For example, in the research and development of some new drugs for specific diseases, 6-NITRO-1H-PYRROLO [2,3-B] PYRIDINE can be used as a starting material through multi-step fine organic synthesis reactions to produce drugs that can effectively act on disease targets.
    In the field of materials science, it also shows certain application potential. In the preparation of some functional materials, this compound can be introduced into the material structure to impart specific physical or chemical properties to the material, such as improving the optical properties and electrical properties of the material, thereby expanding the application of the material in optoelectronic devices and other fields.
    In addition, in the study of organic synthetic chemistry, 6-NITRO-1H-PYRROLO [2,3-B] PYRIDINE is often used as a model compound for researchers to explore new organic synthesis methods and reaction mechanisms. By studying various reactions with it as a substrate, novel chemical reaction pathways can be discovered, improving the efficiency and selectivity of organic synthesis, and providing important theoretical and practical basis for the development of organic chemistry.
    In summary, although 6-NITRO-1H-PYRROLO [2,3-B] PYRIDINE is an organic compound, it plays an indispensable role in many fields such as medicine, materials and organic synthesis, and is of great significance to promoting the development of related fields.
    What are the physical properties of 6-NITRO-1H-PYRROLO [2,3-B] PYRIDINE
    6 - NITRO - 1H - PYRROLO [2,3 - B] PYRIDINE is an organic compound. The physical properties of this substance are particularly important, and it is related to its performance in various chemical processes and practical applications.
    First talk about the appearance. At room temperature and pressure, 6 - NITRO - 1H - PYRROLO [2,3 - B] PYRIDINE is often in a solid state. Its solid form may be crystalline, and the characteristics of the crystal form can affect its many properties. For example, the degree of regularity of crystallization will affect its density. The regular crystalline structure or higher density, and the irregular density may be slightly lower.
    Besides the melting point, this compound has a specific melting point. The melting point is the temperature at which a substance changes from solid to liquid. 6 - NITRO - 1H - PYRROLO [2,3 - B] PYRIDINE's melting point is determined by intermolecular forces. There are various forces between molecules, such as van der Waals forces, hydrogen bonds, etc. The strength of these forces determines the melting point. If the intermolecular force is strong, more energy is required to overcome it, and the melting point is high; otherwise, it is low.
    Solubility is also a key physical property. 6 - NITRO - 1H - PYRROLO [2,3 - B] PYRIDINE has different solubility in different solvents. In organic solvents, such as common ethanol, dichloromethane, etc., it may have a certain solubility. This is because organic solvents can form similar interactions with the molecules of the compound, following the principle of "similar miscibility". However, in water, its solubility may be low, because the polarity of the molecular structure is quite different from that of water, and it is difficult for water molecules to form effective interactions with compound molecules.
    In addition, the density of 6-NITRO-1H-PYRROLO [2,3-B] PYRIDINE also has its own characteristics. Density reflects the mass of a substance per unit volume and is affected by the molecular structure and the way of packing. The compactness of its molecular structure, the type and number of atoms will affect the density. Those with compact structures and heavy atoms tend to have higher densities.
    In terms of optical properties, the compound may have a specific absorption spectrum. The conjugated system within its molecular structure can absorb light of specific wavelengths and exhibit absorption peaks in the ultraviolet-visible spectral region. This property can be used for identification and quantitative analysis. The presence and content of compounds can be known by detecting the location and intensity of absorption peaks with the help of spectrometers.
    In summary, the physical properties of 6-NITRO-1H-PYRROLO [2,3-B] PYRIDINE, such as appearance, melting point, solubility, density and optical properties, are determined by its molecular structure and are of great significance in chemical research and practical applications.
    Is the chemical properties of 6-NITRO-1H-PYRROLO [2,3-B] PYRIDINE stable?
    6 - NITRO - 1H - PYRROLO [2,3 - B] PYRIDINE is one of the organic compounds. To determine whether its chemical properties are stable, it is necessary to investigate from multiple angles.
    In terms of its molecular structure, this compound contains the structure of nitro and pyrrolido-pyridine. Nitro has strong electron-absorbing properties and can often affect the electron cloud distribution and reactivity of molecules. In chemical reactions, nitro is prone to participate in nucleophilic substitution, reduction and other reactions, indicating that its chemical properties are not completely stable. Taking nucleophilic substitution as an example, nitro can reduce the electron cloud density on the pyridine ring, making specific positions on the ring more vulnerable to attack by nucleophilic reagents, and then substitution reactions occur.
    Furthermore, although the structure of pyrrole-pyridine has certain aromaticity, it can endow molecular partial stability. However, the connection between pyrrole ring and pyridine ring is also a reactivity check point due to the difference in atomic hybridization and electron cloud distribution. Under specific conditions, in case of strong acid, strong base or high temperature, pyrrole-pyridine structure may undergo ring opening, rearrangement and other reactions, which all indicate that its stability is limited.
    From the perspective of common chemical reaction conditions, if it is in an oxidizing environment, the nitro group may be further oxidized, resulting in molecular structure changes; if it is under reduction conditions, the nitro group is easily reduced to other groups such as amino groups. And if this compound encounters active reagents, such as strong nucleophiles or strong oxidizing agents, it is prone to chemical reactions, which shows that it is not a highly stable substance in the general chemical environment.
    In summary, the chemical properties of 6-NITRO-1H-PYRROLO [2,3-B] PYRIDINE are not very stable, and can undergo chemical reactions under various conditions, causing molecular structure changes.
    What are the synthesis methods of 6-NITRO-1H-PYRROLO [2,3-B] PYRIDINE
    6 - NITRO - 1H - PYRROLO [2,3 - B] PYRIDINE is one of the organic compounds. The common methods for its synthesis are as follows.
    First, the nitrogen-containing heterocyclic compound is used as the starting material, and the nucleophilic substitution reaction is carried out. First, take a suitable pyridine derivative and make it meet the nitro-containing nucleophilic reagent. Under appropriate reaction conditions, such as in a suitable solvent and a specific base catalyst, the nitro part in the nucleophilic reagent can replace the group at a specific position on the pyridine ring. After fine regulation of the reaction temperature and time, the reaction proceeds in the direction of generating the target product. This process is like a carefully laid out battle. The proportion of each reactant and the control of the reaction conditions are all crucial. With a slight difference, it is difficult to achieve the expected results.
    Second, the cyclization reaction strategy is adopted. Chain compounds containing specific functional groups are selected to form rings through intramolecular reactions. For example, enamines and nitroaromatic hydrocarbons containing appropriate substituents are selected, and under the action of a specific catalyst, they undergo intramolecular cyclization to construct the core structure of pyrrolidine, which is then modified to introduce nitro groups to achieve 6-NITRO-1H-PYRROLO [2,3-B] PYRIDINE. This path is like building a delicate pavilion. Every step of cyclization and modification requires exquisite skills to make the pavilion stable and expected.
    Third, the reaction catalyzed by transition metals. Transition metal complexes are used as catalysts, such as complexes of metals such as palladium and copper, to promote the coupling reaction of related substrates. Let suitable halogenated pyridine derivatives and nitro-substituted alkynes or other unsaturated hydrocarbons be catalyzed by transition metals to achieve the formation of carbon-carbon or carbon-nitrogen bonds, and then build the skeleton of the target molecule. This method uses a metal as a baton to lead the substrate to dance and accurately combine into the desired product, which requires high catalyst selection and optimization of the reaction system.
    The above synthesis methods have their own advantages and disadvantages. The nucleophilic substitution reaction is more direct, but the selectivity of the raw material is high; the cyclization reaction can build a complex ring structure, but the reaction conditions are sometimes harsh; although the transition metal catalytic reaction is efficient and accurate, the cost of the catalyst and post-processing may be difficult. The synthesizer should choose the appropriate method according to the actual situation, such as the availability of raw materials, cost considerations, product purity requirements, etc., in order to achieve the purpose of efficient synthesis of 6-NITRO-1H-PYRROLO [2,3-B] PYRIDINE.
    What is the price range of 6-NITRO-1H-PYRROLO [2,3-B] PYRIDINE in the market?
    I think what you are asking is the price range of 6 - NITRO - 1H - PYRROLO [2,3 - B] PYRIDINE in the market. However, the price of this product often changes due to various reasons, which is difficult to determine.
    First, supply and demand determine its price. If there are many people who want it, and there are few people who supply it, the price will rise; on the contrary, if the supply exceeds the demand, the price may drop. Second, the quality is also related to the price. Those with high purity and good quality are expensive; those with low purity and many impurities are slightly less expensive. Third, the preparation method and cost are also important reasons. If the preparation method is complicated and the cost is high, the price will also be high; if the preparation is simple and the cost is low, the price is expected to drop.
    Furthermore, the competition situation in the market also affects the price. The competition between peers is fierce, and in order to gain share, there may be price reductions; if there is no competition, the price may be maintained high.
    As for the specific price range, it is difficult to be precise. For details, you can consult the chemical product trading platform, supplier, or refer to past transaction records to get a more accurate price range.