6-methoxypyridine-2-carboxamide

6-Methoxypyridine-2-formamide, this material has unique chemical properties. Its appearance is often white to off-white crystalline powder, which is easy to identify and is an important characteristic in chemical experiments and industrial production observation operations.
In terms of solubility, it has a certain solubility in organic solvents such as ethanol and dichloromethane. This property can be skillfully used in organic synthesis for separation and purification steps. For example, by taking advantage of the difference in solubility in different solvents, high-purity products are obtained by extraction, recrystallization, etc.
When it comes to chemical activity, in 6-methoxypyridine-2-formamide, methoxy and amide groups are both key activity checking points. Methoxy groups have a electron cloud effect, which can affect the electron cloud density of the pyridine ring, making the pyridine ring more prone to electrophilic substitution at specific positions. The properties of amide groups are relatively stable, but under specific conditions, such as strong acid or strong base environment, they can be hydrolyzed to form corresponding acids and amines. This hydrolysis reaction is of great significance in organic synthesis and drug metabolism research.
In addition, the molecular structure of 6-methoxypyridine-2-formamide endows it with certain stability and reaction selectivity. Under suitable catalysts and reaction conditions, it can participate in a variety of organic reactions, such as the substitution reaction with halogenated hydrocarbons, to construct more complex organic molecular structures, which has shown broad application prospects in the fields of medicinal chemistry and materials science.

6-Methoxypyridine-2-formamide, this substance has a wide range of uses. In the field of medicine, it is a key intermediate. The structure of Geinpyridine and formamide is crucial in many drug molecules, and 6-methoxypyridine-2-formamide can be converted into pharmaceutical components with specific biological activities by means of chemical synthesis. For example, some drugs used to treat cardiovascular diseases use it as a starting material in the synthesis process. Through multi-step reactions, complex and pharmacologically active molecular structures are constructed to achieve the purpose of regulating cardiovascular physiological functions.
In the field of pesticides, it also has important functions. It can be used as an important intermediate for the synthesis of new pesticides. Pyridine compounds have significant biological activity against many pests. 6-methoxypyridine-2-formamide can be chemically modified to develop pesticide products with high efficiency in killing or repelling pests. For example, for some pests that suck plant sap, the synthesized pesticides can interfere with the nervous system or physiological and metabolic processes of pests, thereby protecting crops from insect infestation and improving crop yield and quality.
In the field of materials science, 6-methoxypyridine-2-formamide also shows potential application value. Due to its specific chemical structure, it can participate in the synthesis of polymer materials. For example, in the preparation of certain functional polymers, they are introduced into the polymer backbone or side chain, imparting special optical, electrical or thermal properties to the polymer, providing the possibility for the development of new high-performance materials, which may be used in electronic devices, optical instruments, and other fields.

The synthesis method of 6-methoxypyridine-2-formamide is not detailed in the ancient book "Tiangong Kaiwu", but there are various ways to deduce it based on today's chemical theory.
First, using 6-methoxypyridine-2-formic acid as the starting material, co-heating with dichlorosulfoxide, the carboxyl group of formic acid is converted into acyl chloride, which is an active intermediate. After interacting with ammonia gas or ammonia alcohol solution, the nucleophilic substitution of acyl chloride and ammonia occurs, and 6-methoxypyridine-2-formamide can be obtained. During the reaction, the temperature needs to be properly controlled to prevent side reactions. The amount of dichlorosulfoxide, when slightly more than formic acid, to promote the reaction to complete.
Second, 6-methoxy-pyridine-2-formic acid interacts with oxalyl chloride to form an acid chloride. This process is relatively mild, oxalyl chloride can be slightly excessive. Then, the acid chloride is reacted with concentrated ammonia water or ammonia gas at low temperature, and careful operation can be used to obtain the target product. The low temperature is set to prevent the disturbance of hydrolysis of acid chloride and side reactions.
In addition, 6-methoxy-2-cyanopyridine is used as a raw material for hydrolysis and amidation. Under basic or acidic conditions, the cyano group is gradually hydrolyzed to an amide group. If alkaline conditions, such as sodium hydroxide solution, are used for heating and refluxing, the reaction process needs to be monitored in a timely manner to prevent excessive hydrolysis into carboxylic acids. Under acidic conditions, strong acids such as sulfuric acid are commonly used, and temperature control and reaction time are also required to ensure that cyanyl groups are properly hydrolyzed into amides to obtain 6-methoxypyridine-2-formamide.
All synthesis methods have advantages and disadvantages, and need to be carefully selected according to factors such as the availability of raw materials, cost considerations, difficulty of reaction, and purity of the product.

6-Methoxypyridine-2-formamide is on the market, and its price range is difficult to determine. The price of this substance often changes for many reasons.
First, it is related to the production method. If it is obtained by a simple and low-cost method, its price may be slightly lower; however, if the production method is complicated, and rare raw materials, fine steps, and exquisite skills are required, the price will be high.
Second, the price of raw materials is also heavy. If raw materials are easy to purchase and affordable, the price of finished products may also be close to the people; if raw materials are rare and difficult to purchase, their price will rise.
Third, the supply and demand of the market is essential. If there are many applicants, there are few suppliers, and rare goods are more expensive, the price will rise; if the supply exceeds the demand, the merchant will sell the goods or reduce the price.
Fourth, the place of production and the cost of transportation are also involved. The origin is close to the city, the freight is provincial, and the price may be favorable; if it travels far and wide, the freight will be voluminous, and the price will also increase.
Furthermore, the difference in quality also affects the price. High-quality products have few impurities and high purity. They are favored in places with strict quality requirements such as medicine and scientific research, and the price is high; those with inferior quality have low prices.
Therefore, in order to know the exact price of 6-methoxypyridine-2-formamide, various factors must be carefully considered. However, roughly speaking, in the chemical raw material market, the price may range from tens to hundreds of yuan per kilogram, which is only a guess. The actual price should be subject to real-time market conditions.

6-Methoxypyridine-2-formamide is an important organic compound that is widely used in the fields of medicine, pesticides, etc. However, finding its manufacturer is like exploring a treasure hidden in the world, which needs to be carefully studied.
In today's world, many chemical companies are involved in the production of such compounds. If there are large-scale fine chemical enterprises in China, they have a large scale in the production of this product by virtue of advanced production technology and strict quality control. Such enterprises often have complete R & D and production systems, which can ensure high product quality and stable supply.
There are also some companies specializing in the production of pharmaceutical intermediates, and they also produce 6-methoxypyridine-2-formamide. They pay attention to the purity and quality of the products to meet the stringent requirements of the pharmaceutical industry.
There are also many manufacturers of this compound overseas. Some European and American chemical companies, with their deep technical accumulation and advanced equipment, produce 6-methoxypyridine-2-formamide with a good reputation in the international market. Its production process may be unique, and the product quality is also of high quality.
However, in order to know the details of the manufacturer, it is necessary to obtain accurate and detailed information through chemical product catalogs, industry exhibitions, professional chemical websites, etc., and to find suitable product sources for those who need them.