6-Methoxy-3-pyridinecarboxaldehyde

6-Methoxy-3-pyridyl formaldehyde is an organic compound. It has unique physical properties and is of great significance to chemistry and related fields.
When it comes to appearance, this compound is mostly colorless to light yellow liquid or solid at room temperature. The color and morphology vary depending on the purity and environment. If the purity is good, or it is in the state of a colorless and transparent liquid, if it contains impurities, the color may be slightly darker.
Its melting point is one of the key physical properties. After many experiments, the melting point of 6-methoxy-3-pyridyl formaldehyde is about [X] ° C. The exact value of the melting point is essential for the identification and purification of this compound. By measuring the melting point, its purity can be judged. If the measured melting point is consistent with the literature value, it indicates high purity; if there is a deviation, it may contain impurities.
The boiling point is also an important characteristic. Under normal pressure conditions, its boiling point is roughly at [X] ° C. Boiling point information is of great significance for the separation and purification of the compound by distillation and other means. Knowing the boiling point, a suitable distillation temperature can be set to separate 6-methoxy-3-pyridine formaldehyde from other substances with different boiling points.
In terms of solubility, 6-methoxy-3-pyridine formaldehyde has good solubility in organic solvents, such as ethanol, ethyl ether, dichloromethane, etc. This property facilitates its application in organic synthesis reactions. It can often be used as a reaction solvent or a raw material to participate in the reaction. With its solubility characteristics in organic solvents, it can achieve uniform mixing with other reactants and promote the reaction. However, its solubility in water is poor, and this property needs special consideration in some reactions or separation processes involving aqueous phases.
The physical properties of 6-methoxy-3-pyridine formaldehyde, such as appearance, melting point, boiling point and solubility, have a profound impact on its application in chemical synthesis, analytical testing and other fields. Accurately grasping these properties is the basis for the effective use of this compound.

The synthesis method of 6-methoxy-3-pyridine formaldehyde, although the ancient book "Tiangong Kaiwu" does not directly describe this substance, it can be deduced from the synthesis of similar compounds.
First, pyridine is used as the starting material. The aldehyde group is introduced before the 3rd position of pyridine, and the Vilsmeier-Haack reaction can be used. Pyridine is co-heated with N, N-dimethylformamide and phosphorus oxychloride, and the formyl group is introduced at the 3rd position through electrophilic substitution to obtain 3-pyridine formaldehyde. Thereafter, methoxy is introduced at the 6th position. 3-Pyridine formaldehyde can be brominated first, bromine atoms are introduced at the 6th position, and then treated with sodium methoxide. After nucleophilic substitution, bromine is replaced by methoxy to obtain 6-methoxy-3-pyridine formaldehyde.
Second, 6-methoxy-pyridine is used as the starting material. First, it is made into the corresponding lithium salt or magnesium salt, and then reacted with N, N-dimethylformamide or other suitable formylating agents to directly introduce the aldehyde group at the 3rd position to obtain 6-methoxy-3-pyridine formaldehyde. This process requires attention to the control of reaction conditions, such as temperature, solvent selection, etc., to ensure the smooth progress of the reaction and the purity of the product.
Or from natural products containing methoxy and pyridine rings, the aldehyde group can be gradually introduced through chemical modification, but this approach is often limited by the source of raw materials and the complexity of the reaction. In short, there are many methods for synthesizing 6-methoxy-3-pyridine formaldehyde. It is necessary to consider the availability of raw materials, cost and difficulty of reaction according to the actual situation, and choose the appropriate one.

6-Methoxy-3-pyridyl formaldehyde, which has a wide range of uses, is a key intermediate in the synthesis of many drugs in the field of medicinal chemistry. For example, some heterocyclic compounds with specific biological activities, when building molecular structures, 6-methoxy-3-pyridyl formaldehyde is often the starting material. After multi-step reactions, it ingeniously builds a pharmaceutical activity skeleton, which helps to develop innovative drugs for treating specific diseases.
In the field of materials science, it also has its own influence. It can participate in the preparation of certain functional materials. With its unique chemical structure, it endows the materials with specific properties, such as adsorption to specific substances or photoelectric response characteristics, etc., providing the possibility for the creation of new functional materials.
Furthermore, in the field of organic synthetic chemistry, it is an extremely important synthetic building block. Organic chemists can synthesize complex and diverse organic compounds by ingenious transformation of their aldehyde groups and methoxy groups, expand the variety of organic compounds, and contribute to the development of organic synthetic chemistry. In short, 6-methoxy-3-pyridine formaldehyde plays an important role in many scientific fields and is of great significance to promote the development of related fields.

6-Methoxy-3-pyridyl formaldehyde, this is an organic compound. In the market, its price often varies depending on the purity, supply, and purchase quantity.
If purchased from ordinary chemical raw material suppliers, the price per gram may be in the tens of yuan if the quantity is small and the purity is about 95%. However, if the purchase quantity increases significantly, such as reaching the kilogram level, the unit price may be reduced to a few to ten yuan per gram due to economies of scale.
If high purity is required, if the purity is more than 98%, the price will rise significantly. The price of such high-purity products may exceed 100 yuan per gram.
Furthermore, prices vary in different regions due to differences in logistics costs and market supply and demand. Prosperous commercial ports, due to convenient logistics, fierce competition, or slightly lower prices; remote places, due to high transportation costs, prices may be slightly higher.
In short, if you want to know its accurate market price, you must consult chemical raw material suppliers in detail, or check and compare it on the chemical product trading platform to obtain the actual price.

6-Methoxy-3-pyridine formaldehyde is an organic compound. When storing and transporting, many things need to be paid attention to.
First safety protection. This compound may be toxic and irritating. When exposed, be sure to wear suitable protective equipment, such as gloves, goggles and gas masks, to prevent it from coming into contact with the skin, eyes, or inhaling into the body, causing damage to the human body.
The second is the storage environment. It should be stored in a cool, dry and well-ventilated place. Avoid direct sunlight, because light or chemical reactions cause it to occur, which affects the quality. At the same time, keep away from fire and heat sources, because it may be flammable, in case of open fire, hot topic or cause combustion danger.
Then there is the storage container. Suitable packaging materials and containers should be selected. Generally speaking, glass or plastic bottles with excellent sealing performance should be used to prevent leakage. And key information such as the name, specification, and production date of the compound should be clearly marked on the container for identification and management.
The transportation process should not be ignored. To follow relevant transportation regulations and standards. During transportation, ensure that the container is stable and avoid collision and vibration to prevent leakage due to damage to the container. For long-distance transportation, pay more attention to the temperature and humidity control of the transportation environment to ensure its stability.
In addition, it is also necessary to pay attention to its compatibility with other substances. During storage and transportation, do not mix or transport with oxidizing agents, acids, alkalis, and other substances to prevent violent chemical reactions from occurring and causing safety accidents.