6-Isopropoxypyridine-3-boronic acid

Potassium 6-isopropoxybenzene-3-carboxylate is an important intermediate in organic synthesis and has key uses in many fields.
First, it plays an indispensable role in the field of medicinal chemistry. It is often used as the starting material or key structural fragment for the construction of many drug molecules. Because of its specific chemical structure, it can participate in a variety of chemical reactions to precisely build a drug molecular skeleton with specific pharmacological activities. By modifying and modifying its structure, a series of drugs for the treatment of different diseases can be developed, such as the development of related drugs for cardiovascular diseases and neurological diseases.
Second, in the field of materials science, potassium 6-isopropoxybenzene-3-carboxylate also plays an important role. It can be used as a key component in the synthesis of specific functional materials, such as for the preparation of polymer materials with special optical and electrical properties. The materials formed by its participation in the reaction may have good conductivity, fluorescence, etc., and show potential application value in electronic devices, optical sensors, etc.
Furthermore, in the field of fine chemicals, this compound is often used in the synthesis of various fine chemicals. Preparation of high-performance coatings, fragrances, additives, etc. Adding compounds containing this structure to coatings may improve the adhesion and corrosion resistance of coatings; in the synthesis of fragrances, its unique structure may impart special aroma characteristics to fragrances; as an additive, it can enhance the specific properties of products and meet the needs of different industrial production.
In short, 6-isopropoxybenzene-3-carboxylate potassium, with its unique chemical structure and reactivity, is an important basic raw material in many fields such as pharmaceutical chemistry, materials science, and fine chemicals, promoting technological development and product innovation in various fields.

The synthesis method of 6-isobutoxyphenyl-3-carbonyl acid is covered by the following numbers.
First, the halogenated hydrocarbon and phenol salt are used as the beginning, and the ether bond can be obtained through the Williamson Ether Synthesis reaction. First, take the halogenated isobutane, and the phenolic compound in an alkaline environment, such as potassium carbonate as the base, in a suitable solvent, such as acetone, heat and stir, and the halogenated isobutane is replaced by the oxygen anion of the phenolic hydroxyl group to form the isobutoxybenzene intermediate. Subsequently, the carbonyl group is introduced into the intermediate. With Friedel-Crafts acylation, acetyl chloride or acetic anhydride can be used as acylation reagents. Under the catalysis of Lewis acids such as anhydrous aluminum trichloride, acetyl groups can be introduced into the benzene ring, and then oxidized and converted into carbonyl acids.
Second, start from the carboxylic acid containing the benzene ring. If the benzoic acid derivative is used as the starting material, the carboxyl group on the benzene ring is properly protected to prevent subsequent reaction interference. The carboxyl group is protected by a protective group such as tert-butyl dimethylsilyl (TBDMS). After that, the halogen atom is introduced at a specific position in the benzene ring through halogenation reaction, such as under the action of light or initiator, and reacts with halogen elemental substance. Then isobutanol is used as the nucleophilic reagent. Under basic conditions, it undergoes nucleophilic substitution with halobenzene to form the isobutoxylbenzene structure. Finally, the carboxyl protecting group is removed, and the carboxyl group is modified according to the needs to achieve the synthesis of carbonyl acid.
Third, with the help of Grignard reagent. First, phenyl Grignard reagent is prepared from halobenzene, such as bromobenzene and magnesium chips are reacted in anhydrous ethyl ether to obtain phenyl magnesium bromide. At the same time, carbonyl compounds containing isobutoxyl groups, such as isobutoxy acetaldehyde, are prepared. The phenyl Grignard reagent is reacted with the carbonyl compound to form an alcohol intermediate. After oxidation step, such as oxidation with Jones reagent, the target 6-isobutoxy phenyl-3-carbonyl acid can be obtained. This number method has its own advantages and disadvantages. The actual synthesis needs to be selected according to the availability of raw materials and the ease of control of the reaction conditions.

6-Isobutoxy phenyl-3-carbonyl butyric acid, its physical and chemical properties are as follows.
The morphology of this compound is mostly solid at room temperature, but depending on its purity and surrounding environmental conditions, it may be semi-solid or even viscous liquid. Looking at its color, when it is pure, it is usually colorless or slightly yellowish. If it contains impurities, the color may change.
When it comes to solubility, it has good solubility in organic solvents, such as ethanol, ether, chloroform, etc. Due to the molecular structure of the compound, it has certain pro-organic solvent properties and can form suitable interactions with the molecules of organic solvents, so it can be soluble. However, in water, its solubility is very small, and it is difficult to form an effective interaction with water molecules due to the large proportion of hydrophobic parts in the molecule.
Its melting point is also one of the important physical properties. After experimental determination, the melting point of the substance is in a specific temperature range, which is an important indicator for its various chemical reactions and practical applications. The value of the melting point can help to identify the purity of the compound. If the purity is high, the melting point range is narrow and approaches the theoretical value; if it contains impurities, the melting point is reduced and the range is wider.
In terms of chemical properties, the carbonyl group and other functional groups in the molecule of 6-isobutoxy phenyl-3-carbonyl butyric acid give it a certain reactivity. Carbonyl groups can undergo reactions such as nucleophilic addition reactions. When encountering nucleophilic reagents, the nucleophilic part of the reagent is easy to attack the carbon atom of the carbonyl group, which in turn triggers a series of chemical reactions. And its carboxyl group part, which is acidic, can neutralize with bases to form corresponding carboxylic salts. And under suitable reaction conditions, carboxyl groups can also participate in esterification reactions and react with alcohols to form ester compounds.
All these physical and chemical properties are key considerations in the synthesis, separation, purification and application of the compound in the fields of medicine, chemical industry, etc.

6-Isopropoxyacetophenone-3-sulfonic acid in storage and transportation, many precautions need to be paid attention to.
When storing, the first environment is dry. If this substance encounters water vapor, it is prone to deliquescence, causing its quality to be damaged. In the warehouse, the humidity should be controlled in a specific range, and moisture should not be intruded. And it should be placed in a cool place to avoid heat sources and open flames. Because it is quite sensitive to temperature, under high temperature, it may cause chemical reactions, causing changes in properties, and even safety risks. Furthermore, it should be stored in isolation from oxidants, acids, bases, etc. Contact with these substances, or react violently, is very harmful.
During transportation, the packaging must be solid. Appropriate packaging materials are required to ensure that it is not affected by vibration and collision during transportation, and will not be damaged and leaked. The transportation vehicle should also be clean, dry, and equipped with corresponding fire and explosion-proof facilities. During driving, drivers should drive slowly to avoid sudden braking and sharp turns to prevent damage to the packaging. Transportation personnel must also be familiar with the characteristics of this substance and emergency treatment methods. In case of leakage and other situations, it can be handled quickly and properly to minimize harm. During loading and unloading, special care should be taken, and it is strictly forbidden to throw, heavy pressure, and keep the packaging intact. In this way, it is necessary to ensure that 6-isopropoxyacetophenone-3-sulfonic acid is safe during storage and transportation.

Today there are 6-isopropoxypyridine-3-boronic acid, what is the market price?
I heard that the price of things in the market often varies depending on the quality, quantity, time and place. 6-isopropoxypyridine-3-boronic acid is no exception.
If its quality is high and pure, and meets all standards, it is a good product, and the price may be slightly higher; if the quality is sub-heterogeneous and does not match the requirements, the price should be lower.
In addition, if the purchase quantity is large, the merchant may give a discount to reduce the unit price in order to promote the sale; if the quantity is small, the price may be as usual. < Br >
The passage of time can also make the price change. Or the price rises and falls due to the increase or decrease of production and the prosperity of demand. If the production is prosperous and the demand is weak, the price will tend to fall; if the production is thin and the demand is prosperous, the price will tend to rise.
As for the distance of the land and the state of supply and demand, it also affects its price. If the production is nearby and the supply is sufficient, the price may be easy; if the supply is short in the distance, the price may increase. < Br >
Therefore, in order to know the exact price of 6-isopropoxypyridine-3-boronic acid, it is difficult to answer it with a blanket price.