6-Hydroxypyridine-3-Carbaldehyde

6-Hydroxypyridine-3-formaldehyde, which is a white-like to light yellow crystalline powder. Its melting point is between 173-175 ° C. This is an important physical characterization, which is related to the temperature limit of its phase transition.
In terms of solubility, it is slightly soluble in water. Water is the source of all things, and many substances show different solubility properties in it. 6-Hydroxypyridine-3-formaldehyde has limited solubility in this solvent, but it exhibits good solubility in organic solvents such as ethanol and dichloromethane. Ethanol, a common organic solvent, has a certain polarity, and there are specific interactions with 6-hydroxypyridine-3-formaldehyde molecules, such as hydrogen bonds, van der Waals forces, etc., to promote its dissolution; dichloromethane can also interact with 6-hydroxypyridine-3-formaldehyde by virtue of its molecular structure and properties, so that it can be dispersed.
Looking at its stability, under normal environmental conditions, 6-hydroxypyridine-3-formaldehyde can still maintain a relatively stable state. However, it should be noted that this substance is quite sensitive to air, light and humidity. In the air, oxygen and other components may undergo chemical reactions such as oxidation, causing their structure to change; under light, photon energy may trigger processes such as intramolecular electron transitions, destroying the original chemical structure; changes in humidity, water molecules may participate in its chemical reactions, or affect its crystalline form. Therefore, when storing, it is necessary to choose a dry, cool and dark place, and seal it properly to protect the stability of its chemical properties and protect its quality from external factors.

6-Hydroxypyridine-3-formaldehyde, the chemical properties of this substance are of great value for investigation. In its molecular structure, the specific position of the hydroxyl group and the aldehyde group coexist in the pyridine ring gives it unique chemical activity.
Hydroxyl group, nucleophilic. Under suitable reaction conditions, it is easy to react with electrophilic reagents. In case of acyl chloride, the oxygen atom of the hydroxyl group will nucleophilically attack the carbonyl carbon of the acyl chloride, and then form ester derivatives. This reaction is a common route for the construction of ester bonds in organic synthesis. And hydroxyl groups can participate in the formation of hydrogen bonds, which has a significant impact on the physical properties of the compound, such as melting point, boiling point and solubility. Due to the presence of hydrogen bonds, its melting point or analogs without such effects are higher, and its solubility in polar solvents is also good.
The aldehyde group is also an active functional group. Classical oxidation reactions can occur. In case of weak oxidants, such as tolan reagent, the aldehyde group will be oxidized to carboxyl groups to form 6-hydroxypyridine-3-carboxylic acid. In the reduction reaction, the aldehyde group can be reduced to alcohol. If treated with a reducing agent such as sodium borohydride, 6-hydroxy-3-hydroxymethylpyridine can be obtained. At the same time, aldehyde groups can react with compounds containing amino groups to form Schiff bases. This reaction is widely used in organic synthesis and biochemistry, and is often an important means to construct nitrogen-containing heterocycles or study the interactions between biomolecules.
Pyridine rings endow molecules with certain alkalinity. Due to the existence of nitrogen atoms, protons can be accepted. Although their alkalinity is weaker than that of aliphatic amines, they can exist in the form of protons in a specific acid-base environment, which affects the charge distribution and solubility of compounds. The electron cloud distribution characteristics of the pyridine ring make the substitution reactivity of different positions on the ring different. The substitution reaction of 6-hydroxypyridine-3-formaldehyde is affected by the positioning effect of hydroxyl and aldehyde groups, and the reaction check point and product selectivity have specific rules.

The synthesis of 6-hydroxypyridine-3-formaldehyde often begins with pyridine. Under appropriate reaction conditions, pyridine is introduced into a specific substituent through a specific chemical action to form a pyridine derivative containing the desired substituent.
For example, pyridine can be electrophilically substituted with a specific reagent at a suitable temperature, pressure and catalyst. Select the reagent with the appropriate activity and guide the substituent to fall precisely at the specific position of the pyridine ring, that is, the 6 position and the 3 position, in order to gradually build the structure of the target molecule.
Or, it can be started from a compound with a similar structure and transformed by a functional group. For example, using a compound containing a pyridine ring with convertible functional groups as raw materials, through many reactions such as oxidation, reduction, and condensation, the existing functional groups are gradually converted into hydroxyl and aldehyde groups to achieve the purpose of generating 6-hydroxypyridine-3-formaldehyde.
During the reaction process, the control of the reaction conditions is the key. The temperature can affect the reaction rate and product selectivity; the change of pressure may also have an effect on the reaction equilibrium and process; and the choice and amount of catalyst can significantly change the activation energy of the chemical reaction, which can affect the difficulty and efficiency of the reaction. At the same time, after each step of the reaction, purification methods such as distillation, extraction, and recrystallization are required to obtain high-purity target products 6-hydroxypyridine-3-formaldehyde, which can meet the needs of subsequent experiments or industrial applications.

6-Hydroxypyridine-3-formaldehyde is a unique organic compound that has considerable applications in many fields.
In the field of medicinal chemistry, it can be used as a key intermediate. The unique structure of geinpyridine with aldehyde and hydroxyl groups makes it have the potential to interact with biological macromolecules. Chemists may be able to create new drug molecules by chemically modifying it. If it is used as a starting material, through delicate reaction steps, it may be able to synthesize compounds with specific pharmacological activities, such as antibacterial and anti-inflammatory drugs, it is expected to contribute to human health and well-being.
In the field of materials science, 6-hydroxypyridine-3-formaldehyde has also emerged. Its aldehyde and hydroxyl groups can participate in a variety of chemical reactions to construct special polymer materials. If polymerized, it can form polymers with unique optical and electrical properties, which can be used in the field of optoelectronic materials, such as organic Light Emitting Diode (OLED), solar cells and other devices, contributing to the improvement of material properties.
Furthermore, in the field of coordination chemistry, this compound can be used as a ligand to complex with metal ions due to its ability to coordinate nitrogen and oxygen atoms. The formed metal-organic complexes often exhibit unique structures and properties, or they excel in the field of catalysis, which can efficiently catalyze many organic reactions, improve reaction efficiency and selectivity, or play a role in the field of gas adsorption and separation, achieving precise adsorption and separation of specific gases.

6-Hydroxypyridine-3-formaldehyde, the price of this product in the market is difficult to determine. The price of this product often varies due to various factors, such as the quality of the product, the amount of purchase, the supply and demand of the era, and the difficulty of preparation.
If you talk about quality, high-quality products, with high purity and few impurities, can be worth a high price; while those with lower quality, the price is slightly cheaper. Purchase quantity is also the key. If you buy in bulk, the merchant may give a discount to promote sales, and the unit price will drop. If you buy only a small amount for your own research, the price may be expensive.
The supply and demand of the era are particularly affected. If there are many people in the market who want it, but there are few suppliers, the price will rise; on the contrary, if the supply is abundant and the demand is small, the merchant will also reduce the price in order to sell the goods.
The difficulty of preparation also affects the price. If the preparation process is complicated, time-consuming and expensive, the cost is high, and the price is not low; if the preparation is easy and the cost is controllable, the price may be close to the people.
In the past, this product was rare in the city, and the price was very high. Only a few rich researchers could buy it. Later, the preparation method became better, and the supply increased slightly, but the price dropped. However, today is different from the past, the market conditions are changeable, and the price is also unstable. If you want to know the exact price, you can consult the merchant of chemical materials or explore a professional material trading platform to obtain the current price.