6-(Hydroxymethyl)imidazo[1,2-a]pyridine

6- (hydroxymethyl) imidazolo [1,2-a] pyridine has a wide range of uses. In the field of medicinal chemistry, it is often a key raw material for the creation of new drugs. Due to its unique molecular structure, it has the potential to combine with many targets in the body, which can help chemists develop drugs against various diseases, such as antibacterial, antiviral, and anti-tumor drugs.
In the genus of materials science, 6- (hydroxymethyl) imidazolo [1,2-a] pyridine also has wonderful uses. It can be used to prepare special polymer materials. With its special chemical properties, it can improve the properties of materials, such as enhancing the stability of materials, improving their mechanical strength, or endowing materials with some special functions, making materials stand out in the fields of electronics and optics, and used in the manufacture of new electronic components, optical sensors, etc.
Furthermore, in the field of organic synthesis, this compound is often used as an important intermediate. Chemists can use this to construct more complex and diverse organic molecular structures, expand the boundaries of organic synthesis, and provide an effective way for the creation of new organic compounds, thereby promoting the continuous progress and development of the field of organic chemistry.

To prepare 6 - (hydroxymethyl) imidazolo [1,2 - a] pyridine, there are three methods.
First, imidazolo [1,2 - a] pyridine is used as the beginning, formylated, and then reduced. First take an appropriate amount of imidazolo [1,2 - a] pyridine, place it in a reactor, and dissolve it in a suitable solvent. Add formylating reagents, such as a mixed system of paraformaldehyde and acid, and react at a temperature. After formylation is completed, the temperature is lowered, and a reducing agent, such as sodium borohydride, is used for reduction. At the end of the reaction, the target product can be obtained after separation and purification. This step is slightly complicated, but the raw materials are easy to find, and the reaction conditions are not harsh.
Second, start with 2-aminopyridine and ethyl glyoxylate, first condensation, then cyclization, and then hydroxymethylation. Mix 2-aminopyridine and ethyl glyoxylate in a certain proportion, add a catalyst, and condensate at an appropriate temperature and pressure. The condensation product is treated and then cyclized to obtain imidazolo [1,2-a] pyridine derivatives. Finally, with a suitable hydroxymethylation reagent, such as the system of formaldehyde and base, hydroxymethylation is performed to obtain 6- (hydroxymethyl) imidazolo [1,2-a] pyridine. This route is slightly longer, but the reaction selectivity of each step is good, and the yield is also considerable.
Third, start with pyridine derivatives, and construct an imidazole ring through multi-step reaction and introduce hydroxymethyl groups. Select the appropriate pyridine derivatives, and through substitution, condensation and other reactions, first construct the imidazole ring. After modification, hydroxymethyl groups are introduced. This way requires a good grasp of pyridine chemistry, and precise control of the reaction conditions at each step. However, the route can be flexibly designed according to raw materials and needs.
These three methods have their own advantages and disadvantages. When implementing, the most suitable method should be selected according to factors such as raw material availability, cost, yield and purity.

6 - (hydroxymethyl) imidazolo [1,2 - a] pyridine is a kind of organic compound. Its physical properties are quite important and are listed below:
First, its appearance, under room temperature and pressure, 6 - (hydroxymethyl) imidazolo [1,2 - a] pyridine is mostly white to light yellow crystalline powder. This powder is fine in texture and visually pure.
The melting point is between about 120 ° C and 125 ° C. When the temperature gradually rises, the compound slowly converts from solid state to liquid state. This temperature range is relatively stable, which is its inherent characteristic and is crucial for identification and purification.
Solubility is also one of the important physical properties. It is slightly soluble in water, only a little soluble in water, and the solution is slightly cloudy. However, it has good solubility in common organic solvents, such as ethanol and dichloromethane, and can quickly disperse and dissolve to form a uniform solution. This property is used in organic synthesis reactions to provide a basis for selecting suitable reaction solvents.
Furthermore, its density is also fixed, about 1.35g/cm ³. This value reflects the mass per unit volume of the compound, which is of great significance in the process of material measurement and mixing.
In addition, the stability of 6 - (hydroxymethyl) imidazolo [1,2-a] pyridine is also worthy of attention. Under normal storage conditions, that is, in a cool, dry and dark place, the compound can maintain its chemical structure and properties for a long time. However, exposure to high temperature, high humidity or strong light may cause chemical changes that affect its quality.

6 - (hydroxymethyl) imidazolo [1,2-a] pyridine, this is an organic compound. Its chemical properties are unique, let me talk about them one by one.
First of all, it has a certain hydrophilicity, because the molecule contains hydroxymethyl groups, hydroxyl groups can form hydrogen bonds with water molecules, so it has a certain solubility in water. This property makes it able to exhibit special behavior in some reactions or systems involving the aqueous phase.
Furthermore, the heterocyclic structure of imidazolo [1,2-a] pyridine gives the compound a certain alkalinity. Due to the existence of lone pairs of electrons on the nitrogen atom in the heterocycle, protons can be accepted, thus showing alkalinity. This alkalinity may play a key role in acid-base reactions or catalysis of certain reactions.
In addition, the covalent bonds of carbon-nitrogen bonds and carbon-oxygen bonds in this compound determine its chemical stability. Although such bonds are relatively stable, they may also break and rearrange under certain conditions, such as high temperature, strong acid, strong base or the presence of specific catalysts, which may lead to various chemical reactions. For example, hydroxyl groups in hydroxymethyl groups can participate in esterification reactions and form corresponding esters with carboxylic acids under suitable conditions. < Br >
The imidazolo [1,2-a] pyridine heterocyclic part, due to its conjugate structure, can undergo electrophilic substitution reaction, and introduce other functional groups on the heterocyclic ring, which provides rich possibilities for organic synthesis and can further derive many compounds with unique properties.

I have not heard the exact price of "6 - (Hydroxymethyl) imidazo [1,2 - a] pyridine" on the market. This compound is not commonly available, and its price often varies for many reasons.
First, the difficulty of preparation is the main reason. If the preparation requires complicated steps, special raw materials and conditions, the price must be high. The synthesis of this compound or the method of fine organic synthesis involves strict control of the reaction conditions, and the reagents used may also be precious. This cost increases, resulting in its high market price.
Second, purity is related to price. High purity products are widely used, such as for scientific research and pharmaceutical research and development, with extremely high requirements for impurity content, making it difficult to prepare high-purity products, and the price will also rise. Low purity products may be suitable for general experiments, and the price is relatively low.
Third, supply and demand also affect the price. If the market has a large demand for this product and the supply is limited, the price will rise; if there is less demand and more supply, the price will fall.
However, there is no public and exact price range. To know its price, you can consult chemical reagent suppliers, such as Sinopharm Group Chemical Reagent Co., Ltd., search banner reagent network, etc.; or search on the chemical product trading platform, different suppliers, different purity specifications, the price difference is quite large.