6 Hydroxy 2 Pyridinecarboxylicacid
pyridine pyrrole pyrazine piperidine piperazine

6-Hydroxy-2-PyridineCarboxylicAcid

    Specifications

    HS Code

    687153

    Name 6-Hydroxy-2-PyridineCarboxylicAcid
    Molecular Formula C6H5NO3
    Molar Mass 139.11 g/mol
    Appearance Solid
    Color White to off - white
    Solubility In Water Slightly soluble
    Melting Point 255 - 257 °C
    Pka 2.76 (estimated)
    Boiling Point Decomposes before boiling
    Odor Odorless

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    General Information
    Where to Buy 6-Hydroxy-2-PyridineCarboxylicAcid in China?
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    Frequently Asked Questions

    As a leading 6-Hydroxy-2-PyridineCarboxylicAcid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 6-hydroxy-2-pyridinecarboxylic acid?
    6-Carboxyl-2-aminobenzoic acid, its main uses are as follows:
    In the field of medicine, this compound can be used as an important intermediate for drug synthesis. Covering the way of medicine, it is related to human life. With excellent medicine, diseases can be cured. 6-Carboxyl-2-aminobenzoic acid can be used as a key cornerstone when synthesizing drugs with specific effects because of its unique chemical structure. For example, synthesizing drugs for the treatment of certain inflammation or chronic diseases, it can participate in the construction of a specific skeleton of drug molecules, so that the drug has precise pharmacological activity, so as to achieve the purpose of promoting justice, removing evil and healing diseases.
    In the dye industry, it also plays an important role. Dyes can also add color and add color to fabrics, leather and other materials. 6-Carboxyl-2-aminobenzoic acid can be chemically modified to introduce specific chromogenic groups to prepare dyes with bright colors and excellent fastness. Fabrics colored with this dye can maintain color for a long time under lighting, washing and other environments, meeting the world's demand for long-lasting color of clothing, decoration and other materials.
    In organic synthesis chemistry, it is often used as an important starting material or reaction intermediate. The delicacy of organic synthesis lies in the construction of complex organic molecules from simple raw materials through ingenious reaction steps. 6-Carboxyl-2-aminobenzoic acid contains carboxyl and amino groups, both of which are active reaction check points and can participate in many classic organic reactions, such as esterification and amidation reactions, etc., thereby deriving a wide variety of organic compounds, expanding the field of organic synthesis, and laying the foundation for the research and development of new materials and the preparation of fine chemicals.
    What are the physical properties of 6-hydroxy-2-pyridinecarboxylic acid?
    The carboxyl group is an extremely important functional group in organic chemistry, which is widely present in a variety of organic compounds. As far as the carboxyl group of aminopropionic acid is concerned, it has the following physical properties:
    - ** acidic **: The carboxyl group can be partially ionized in water, releasing hydrogen ions, showing acidity. Taking aminopropionic acid as an example, its carboxyl group can neutralize with bases, such as reacting with sodium hydroxide to form corresponding carboxylic salts and water. This acidity is derived from the strong electronegativity of the oxygen atom of the hydroxyl group in the carboxyl group, which makes the hydrogen-oxygen bond electron cloud biased towards the oxygen atom, causing the hydrogen atom to leave in the form of hydrogen ions.
    - ** Solubility **: Because the carboxyl group is polar, aminopropionic acid forms a hydrogen bond between the carboxyl group and the water molecule, so it has a certain solu However, its solubility is also affected by other parts of the molecule, such as the presence of amino and alkyl groups in aminopropionic acid, which also has an effect on solubility. Usually, small molecule carboxyl-containing compounds have a high solubility in water due to their strong ability to form hydrogen bonds with water; while as the hydrophobic group in the molecule increases, the solubility will gradually decrease.
    - ** Boiling Point and Melting Point **: Carboxyl groups can form hydrogen bonds between molecules, and aminopropionic acid molecules can form hydrogen bonds due to the action of carboxyl groups, resulting in increased intermolecular forces. Compared with similar compounds without carboxyl groups, its boiling point and melting point are relatively high. To transform aminopropionic acid from liquid to gas or from solid to liquid, more energy needs to be provided to overcome intermolecular hydrogen bonds and other forces.
    What are the chemical properties of 6-hydroxy-2-pyridinecarboxylic acid?
    6-Carboxyl-2-pyridinecarboxylic acid, this is an organic compound. Its chemical properties are unique and acidic. Because it contains carboxyl groups, hydrogen ions can be dissociated under suitable conditions, and it shows acidic characteristics in acid-base reactions.
    Its carboxyl group interacts with the pyridine ring, giving the substance unique reactivity. The pyridine ring has a certain electron cloud distribution and can participate in a variety of electrophilic substitution reactions. For example, under specific reagents and conditions, halogenation, nitration, sulfonation and other electrophilic substitutions can occur on the pyridine ring, and the substitution position is affected by the electronic effect and spatial effect of the pyridine ring.
    At the same time, the carboxyl group of 6-carboxyl-2-pyridinecarboxylic acid can carry out many typical car For example, it can be esterified with alcohols under acid catalysis to form corresponding ester compounds. It can also neutralize with bases to form carboxylic salts. In addition, carboxyl groups can also participate in condensation reactions, condensation with amino-containing compounds to form amide bonds.
    From the perspective of coordination chemistry, the nitrogen atom on the pyridine ring has lone pair electrons, which can be used as a ligand to coordinate with metal ions to form metal complexes. This property makes it potentially used in the fields of materials science and catalysis. Because it can bind to metal ions, or can be used to construct complex materials with specific structures and functions, it plays a unique role in catalytic reactions. In conclusion, 6-carboxyl-2-pyridinecarboxylic acid exhibits diverse chemical properties and potential application value due to its own structural characteristics.
    What are the preparation methods of 6-hydroxy-2-pyridinecarboxylic acid?
    The preparation method of 6-carboxyl-2-aminobenzoic acid has been known since ancient times. Many parties have applied wonderful methods and are good at winning the field. The following will be described in detail by you.
    First, with benzoic acid as the group, nitrobenzoic acid can be obtained through nitrification. This process requires a specific reaction environment, and a suitable reagent can be used to ingeniously introduce nitro into the specific position of benzoic acid. Then, by reducing the method, the nitro group is converted into an amino group. This step requires a suitable reducing agent to make the nitro group return to an amino group, and then 6-nitro-2-aminobenzoic acid is obtained. Finally, through the carboxylation reaction, the carboxyl group is introduced, and 6-carboxyl-2-aminobenzoic acid can be obtained. Although the steps are complicated, the principles of each step are clear, and the operation is proper, and a good product can be obtained. < Br >
    Second, phthalic anhydride is used as the starting material, and it is first reacted with ammonia to form phthalimide. Phthalimide can be converted into anthranilic acid under specific conditions through Hoffman degradation reaction. The anthranilic acid is then nitrified, nitro is introduced at a suitable position, and then the target can be obtained by reducing the nitro group and then carboxylation. This path takes a different approach and cleverly uses the characteristics of phthalic anhydride. The reaction steps are interlocking, and the reaction conditions need to be carefully controlled before it can be achieved smoothly.
    Third, using phenol as the starting material, the sulfonation reaction is first carried out to introduce the sulfonic acid group into the phenol molecule. After alkali fusion reaction, the sulfonic acid group is converted into a hydroxyl group, and molecular rearrangement occurs at the same time to form o-hydroxybenzoic acid. After nitrification of o-hydroxybenzoic acid, nitro groups are introduced at specific positions, and then nitro groups are reduced to amino groups. Finally, 6-carboxyl-2-aminobenzoic acid can also be prepared by carboxylation reaction. This approach uses phenol as a base and skillfully uses a variety of reactions to gradually construct the target molecular structure, which is a good method for preparation.
    All kinds of preparation methods have their own advantages, either focusing on the ease of purchase of raw materials, or emphasizing the convenience of reaction, or focusing on the purity of the product. The operator can choose the right one according to their own needs, the convenience of raw materials, and the skill to obtain the required 6-carboxyl-2-aminobenzoic acid.
    What is the price range of 6-hydroxy-2-pyridinecarboxylic acid in the market?
    Hearing you inquire about the price of tortoiseshell, tortoiseshell is a spiritual thing in the sea, and its armor can be made into a rare treasure. In the city, the price is wide and narrow, and it is quite related to various causes.
    The quality of tortoiseshell is pure, moist, beautiful and beautiful, and the price must be high; if it is miscellaneous, dark in color, and messy, the price will be low. Depending on the situation of supply and demand, when people still have their things, there are many people who want them, and the production is rare, the price will jump; if the supply exceeds the demand, the price will drop.
    In the past, tortoiseshell was in the city, or tens of gold to hundreds of gold. However, in this world, tortoiseshell is a rare and protected thing, and it is forbidden to capture and sell it. Although there may be hidden sellers in the market, their prices are not comparable to the right way, and they involve the risk of breaking the law.
    Therefore, it is difficult to know the price of tortoiseshell armor today. Even if there are dark market transactions, the price is also treacherous and changeable, and such acts are against the law and morality, and they are not done by the right way. The world should respect the law to protect students, and should not ask for illegal prices.