6-fluoro-pyridine-2-carboxylic acid amide

6-Fluoropyridine-2-carboxylic acid amide, this is an organic compound. Its physical properties are mostly solid at room temperature, with a white color and a powder-like shape, and a weak odor. The melting point is about [X] ° C, and it has certain solubility in specific organic solvents, such as dichloromethane, N, N-dimethylformamide, but it has poor solubility in water.
In terms of chemical properties, the fluorine atom in this compound has strong electronegativity, causing the electron cloud density of its ortho-pyridine ring to change, making the pyridine ring more prone to nucleophilic substitution reactions. The nitrogen atom of the pyridine ring has lone pairs of electrons, which can act as an electron donor and complex with metal ions to form coordination compounds.
Its amide group also has unique chemical activity. The carbonyl group in the amide group is electrophilic, which can react with nucleophiles, such as amines and alcohols, to derive many different compounds. At the same time, the hydrogen atom on the amide nitrogen atom is weakly acidic, and can participate in acid-base reactions under specific conditions.
This compound is widely used in the field of organic synthesis due to the above chemical properties. It can be used as a key intermediate for the preparation of various drugs, pesticides and functional materials. For example, it is converted into fluoropyridine-containing drugs through a series of reactions, showing biological activities such as antibacterial and anti-tumor. Or in the field of materials science, it is connected to the polymer backbone through chemical reactions, giving materials special properties.

6-Fluoropyridine-2-carboxylic acid amide is one of the organic compounds. It has a wide range of uses in the field of medicinal chemistry and is often a key intermediate for the creation of new drugs. In the current medical research theory, the development of therapeutic drugs for many diseases depends on such compounds. Due to the unique chemical and physical properties of fluorine atoms and amide groups, such as better biological activity and membrane permeability, it can participate in many drug synthesis reactions and help to form compounds with specific pharmacological activities.
In the field of pesticide chemistry, it also has important functions. After proper modification and synthesis, it can be made into pesticides, fungicides and other pesticide products. Due to the characteristics of fluorine atoms, such pesticides are often highly efficient, low toxic and environmentally friendly, and play a key role in the control of crop diseases and pests. They can not only effectively eliminate pests and bacteria, but also reduce the negative impact on the environment and ensure the quality and safety of agricultural products.
Furthermore, in the field of materials science, 6-fluoropyridine-2-carboxylic acid amide has also emerged. It can be used as a raw material for the preparation of special functional materials. After polymerization or other reactions, polymer materials with specific properties can be generated. For example, some materials with excellent electrical and optical properties are used in electronic devices, optical instruments and other industries to promote technological progress and development in related fields.
In conclusion, 6-fluoropyridine-2-carboxylic acid amides have significant uses in many fields such as medicine, pesticides, and materials science, and are of great significance to the development of various fields.

The method of preparing 6-fluoropyridine-2-carboxylic acid amide can be started from 6-fluoropyridine-2-carboxylic acid. First, the 6-fluoropyridine-2-carboxylic acid is co-heated with sulfuryl chloride, and this step aims to convert the carboxyl group into an acid chloride. Sulfuryl chloride is a commonly used chlorination reagent. When the two react, the chlorine atom in the sulfuryl chloride replaces the hydroxyl group in the carboxyl group and escapes sulfur dioxide and hydrogen chloride gas to obtain 6-fluoropyridine-2-formyl chloride.
Then, 6-fluoropyridine-2-formyl chloride is reacted with ammonia gas or ammonia alcohol solution at low temperature. The lone pair electron on the nitrogen atom in the ammonia molecule attacks the carbonyl carbon of the acyl chloride, and the chloride ion leaves. After nucleophilic substitution, 6-fluoropyridine-2-carboxylic acid amide is finally formed. This low temperature condition can effectively avoid the occurrence of side reactions and improve the purity of the product.
There are other ways. First, 6-fluoropyridine-2-carboxylic acid can be esterified with an appropriate alcohol, such as methanol, catalyzed by concentrated sulfuric acid to generate 6-fluoropyridine-2-carboxylic acid methyl ester. Concentrated sulfuric acid is used as a catalyst to accelerate the reaction process. After that, an alcohol solution of ammonia is reacted with 6-fluoropyridine-2-carboxylic acid methyl ester, and ammonia molecules replace methoxy groups to obtain 6-fluoropyridine-2-carboxylic acid amides.
During operation, the dosage of various reagents, reaction temperature and time need to be precisely controlled. If the amount of sulfinyl chloride is insufficient, the carboxyl group cannot be completely converted into acid chloride; if the reaction temperature is too high, it is easy to cause side reactions, which affects the yield and purity of the product. The preparation process must be carried out in a well-ventilated environment, because the gas produced by the reaction is irritating and endangers the health of the operator.

6-Fluoropyridine-2-carboxylic acid amide, is a kind of organic compound. During storage and transportation, many matters need to be paid attention to.
When storing, the first environment. It should be placed in a cool, dry and well-ventilated place, and must not be exposed to direct sunlight. Due to the heat and radiation of sunlight, or the chemical reaction of the compound may occur, which will damage its quality. If the environment is humid, water vapor or interaction with the compound will cause adverse reactions such as hydrolysis. Temperature must also be properly controlled. Excessive temperature can accelerate its decomposition, and too low temperature may cause it to crystallize and solidify, which will affect the use.
Packaging is also key. It must be kept in a well-sealed container to prevent contact with the air. Oxygen, carbon dioxide and other components in the air may react with the compound. And the packaging material is also exquisite. Those with stable chemical properties and no interaction with the compound should be selected to prevent the packaging material from dissolving impurities and contaminating the compound.
During transportation, shock protection and collision prevention are the top priority. The compound may be damaged by violent vibration or collision, and then leak. Once leaked, not only the compound itself is damaged, but also it may pose a threat to the surrounding environment and personal safety. Inside the transportation vehicle, the environment should also be maintained stable, and the temperature and humidity should be controlled as required during storage.
In addition, transportation and storage personnel should be familiar with the characteristics and safety precautions of the compound. In case of emergency, such as leakage, fire, etc., it must be able to be dealt with quickly according to the established emergency plan to reduce the hazard. In this way, the safety and quality of 6-fluoropyridine-2-carboxylamide during storage and transportation must be ensured.

6-Fluoropyridine-2-carboxylic acid amide, the market price range of this product is difficult to determine. The price often varies due to a variety of factors.
First of all, if the preparation process is complicated, rare or expensive raw materials are required, and the production process is tortuous, and the equipment and technology requirements are strict, the cost will be high, and the price will rise accordingly. On the contrary, if the process is simple, the raw materials are easy to obtain and cheap, and the production scale can be produced in batches, the price may be slightly lower.
Look at the state of market supply and demand again. If many industries, such as pharmaceutical research and development, chemical synthesis, etc. have strong demand for it, but the supply is limited, the supply is in short supply, and the price will rise; if the demand is weak, but the output is quite large, and the supply is oversupplied, the price will decline.
In addition, regional differences also have an impact. Different places have different prices due to different transportation costs, tax policies, and market competition. In places with convenient transportation, agglomeration of the chemical industry, and intense competition, the price may be relatively low; in remote areas, inconvenient logistics, and small market competition, the price may be high.
According to past market conditions, the price per kilogram may range from hundreds to thousands of yuan. However, this is only a rough guess. To know the exact price range, it is necessary to carefully examine the current market dynamics and consult professionals such as chemical raw material suppliers and traders, or to obtain a more accurate estimate.