6 Fluoro 3 Hydroxymethyl 2 Methylpyridine
pyridine pyrrole pyrazine piperidine piperazine

6-Fluoro-3-(hydroxymethyl)-2-methylpyridine

    Specifications

    HS Code

    656168

    Chemical Formula C7H8FNO
    Molecular Weight 141.143
    Appearance Solid

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    General Information
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    Frequently Asked Questions

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    What are the physical properties of 6-Fluoro-3- (hydroxymethyl) -2-methylpyridine?
    6-Fluoro-3- (hydroxymethyl) -2-methylpyridine is one of the organic compounds. Its physical properties are unique and are described in detail as follows:
    First appearance, at room temperature and pressure, it is mostly colorless to pale yellow liquid, clear and has a specific visual appearance. The formation of this state is due to the interaction and arrangement of molecules, which makes it exhibit such appearance characteristics under these conditions.
    On the melting point, the melting point is within a specific range due to the mutual restraint of atoms and groups in the structure. However, the exact value varies depending on the purity of the preparation and the testing environment, and is roughly in a certain range. This melting point range determines the phase transition at different temperatures, which is related to its state under specific process and storage conditions.
    Boiling point is an important indicator to measure its volatility. At standard atmospheric pressure, the boiling point is also around a certain value. At this temperature, the molecule obtains enough energy to overcome the intermolecular force and convert from liquid to gaseous state. This boiling point reflects the strength of the intermolecular force and is closely related to the molecular structure.
    In terms of solubility, the substance has good solubility in organic solvents, such as common ethanol, ether, etc. This is because the polar and non-polar parts of the molecular structure are compatible with the organic solvent, and follow the principle of similar dissolution. In water, the solubility is relatively weak because the polarity of water has limited effect on the partial structure of the compound.
    Density is also an important physical property. At a specific temperature, its density is stable at a certain value. This value reflects the mass of the substance in a unit volume, and is related to the size and arrangement of the molecules. It is of great significance to the calculation of material quantity and process design in practical applications.
    The refractive index also cannot be ignored, which reflects the degree of refraction of light when passing through the substance. The specific value of the refractive index is determined by the molecular structure of the substance and the distribution of the electron cloud. It is often used to identify the purity and concentration of the substance, and is of great value in the field of analysis and detection.
    The above physical properties are all derived from the unique molecular structure of 6-fluoro-3- (hydroxymethyl) -2-methylpyridine, and each property is interrelated, which affects its application in many fields such as chemical industry and medicine.
    What are the chemical properties of 6-Fluoro-3- (hydroxymethyl) -2-methylpyridine
    6-Fluoro-3- (hydroxymethyl) -2-methylpyridine is one of the organic compounds. It has unique chemical properties and has important uses in many fields.
    This compound is endowed with special properties because it contains fluorine atoms. Fluorine atoms have high electronegativity, which can enhance molecular stability and affect their physical and chemical behavior. Fluorinated organic compounds often have high lipid solubility and can improve biological activities, so they have attracted much attention in the fields of medicine and pesticide research and development. 6-fluoro-3- (hydroxymethyl) -2-methylpyridine may be used as a key intermediate to synthesize molecules with specific biological activities, such as antibacterial and antiviral drugs.
    The hydroxymethyl group in its molecule is a hydrophilic group and can participate in many chemical reactions. Hydroxymethyl groups can undergo esterification and etherification reactions, whereby different functional groups can be introduced to expand the structural diversity of compounds, and then regulate their physicochemical properties and biological activities. For example, esterification reactions with acids produce corresponding ester derivatives, or change their solubility, stability and bioavailability.
    Furthermore, although the 2-position methyl group has a simple structure, it has a significant impact on molecular properties. Methyl group is a power supply group, which can change the electron cloud density of the pyridine ring, affecting its reactivity and selectivity. At the same time, the steric hindrance effect of methyl groups also affects the interaction between molecules and other substances, and plays an important role in molecular recognition, drug-target binding and other processes.
    The chemical properties of 6-fluoro-3- (hydroxymethyl) -2-methylpyridine make it an important research object in the fields of organic synthesis, pharmaceutical chemistry and other fields, laying the foundation for the development of new drugs and materials.
    What are the common uses of 6-Fluoro-3- (hydroxymethyl) -2-methylpyridine?
    6-Fluoro-3- (hydroxymethyl) -2-methylpyridine, which is one of the organic compounds. In the field of chemical synthesis, its common uses are quite extensive.
    First, in the field of pharmaceutical chemistry, it is often used as a key intermediate. The preparation of many drugs depends on its participation. By modifying and reacting its structure, compounds with specific pharmacological activities can be constructed. For example, in the development of some antibacterial and antiviral drugs, this compound can be converted into drug molecules with better efficacy and stronger targeting through clever reaction steps.
    Second, in the field of materials science, it also has important uses. It can be used as a starting material for the synthesis of special functional materials. By carefully designing chemical reactions to polymerize or react with other compounds, materials with unique electrical, optical or mechanical properties are formed. Such as the synthesis of organic materials with special electrical conductivity properties for use in electronic devices.
    Third, in the process of organic synthetic chemistry, 6-fluoro-3- (hydroxymethyl) -2-methyl pyridine can participate in many types of organic reactions due to its unique structure. Like nucleophilic substitution reactions, oxidation-reduction reactions, etc., to construct more complex and diverse organic molecular structures provide rich possibilities for the development of organic synthetic chemistry, helping scientists to explore the synthesis paths and properties of more novel compounds.
    What are the synthesis methods of 6-Fluoro-3- (hydroxymethyl) -2-methylpyridine
    The synthesis method of 6-fluoro-3- (hydroxymethyl) -2-methylpyridine is of great interest in the field of chemical synthesis. Although this substance is not directly mentioned in Tiangong Kaiwu, the relevant ideas can be found from the ancient chemical synthesis concepts and methods.
    First, it can be started from compounds containing pyridine rings. The ancient chemical synthesis often involves the transformation of natural materials into the desired substance through multiple steps. First, find suitable pyridine derivatives, such as specific substituted pyridine, and introduce fluorine atoms through halogenation reaction. This halogenation process is analogous to the ancient use of halides to interact with materials. It is necessary to find appropriate halogenation reagents and reaction conditions to precisely replace fluorine atoms in the sixth position of the pyridine ring.
    Second, the introduction of hydroxymethyl and methyl. In ancient chemical synthesis, the introduction group often relies on materials with corresponding functional groups. To introduce hydroxymethyl, you can find a reagent containing hydroxymethyl, and through a suitable reaction, such as nucleophilic substitution reaction, the hydroxymethyl group is connected to the 3 position of the pyridine ring. The introduction of methyl is based on the 2 position, or the methylation reaction can be achieved under appropriate conditions by methylation reagents. The control of these reaction conditions, the control of the temperature and the proportion of materials in Jugu's alchemy, pottery and other processes, needs to be repeatedly tried and fine-tuned to achieve the desired reaction effect and improve the yield and purity of the target product. During the synthesis process, each step of the reaction needs to be carefully handled and the reaction process monitored to ensure the smooth synthesis path, resulting in 6-fluoro-3- (hydroxymethyl) -2-methylpyridine.
    What should be paid attention to when storing 6-Fluoro-3- (hydroxymethyl) -2-methylpyridine?
    6-Fluoro-3- (hydroxymethyl) -2-methylpyridine is also an organic compound. When storing this substance, many matters need to be paid attention to.
    The first choice of environment. It should be stored in a cool place, away from heat sources and open flames. The cover can easily cause chemical reactions due to heat, or cause dangers, such as combustion and explosion. Therefore, the warehouse temperature should be controlled within a specific range, and should not be too high.
    Times and humidity. Too high humidity may cause the compound to absorb moisture, affecting its purity and stability. Therefore, it should be stored in a dry place, and a desiccant can be placed next to it to keep the environment dry.
    Furthermore, the choice of container is also important. A well-sealed container is required to prevent contact with air. This compound may react with oxygen, water vapor and other components in the air, causing it to deteriorate. The material of the container used also needs to be adapted, and no chemical reaction should occur with it.
    In addition, the storage place should be well ventilated. If the ventilation is not good, once the compound leaks, its volatile gases will accumulate, which will not only increase the danger but also damage the environment. And do not mix with oxidants, acids, alkalis and other substances. Because of its active chemical properties, contact with them is prone to violent reactions.
    In conclusion, proper storage of 6-fluoro-3- (hydroxymethyl) -2-methylpyridine requires attention to ambient temperature and humidity, container sealing and ventilation, and avoidance of co-storage with incompatible substances, so as to ensure its quality and safety.