6-Fluoro-2-methylpyridine-3-boronic acid

6-Fluoro-2-methylpyridine-3-boronic acid is an important intermediate in organic synthesis and is widely used in many fields such as medicine, pesticides, and materials science. Its chemical properties are unique and of great research value.
In terms of structure, this compound contains boron atoms. The special outer electronic structure of boron atoms makes it electron-deficient, which makes it easy to react with electron-rich groups and can participate in a variety of organic reactions, such as Suzuki-Miyaura coupling reaction. In this reaction, 6-fluoro-2-methylpyridine-3-boronic acid can form carbon-carbon bonds with halogenated aromatics under the action of palladium catalysts and bases, and construct complex organic molecular structures, which is of great significance for the synthesis of organic compounds with specific structures and functions.
Furthermore, the compound contains fluorine atoms and methyl groups. Fluorine atoms have strong electronegativity. When introduced into molecules, they can significantly change the distribution of molecular electron clouds and affect their physical and chemical properties. For example, enhancing the lipophilicity of molecules has an impact on their absorption, distribution, and metabolism in living organisms, which is particularly critical in drug development and can improve the pharmacokinetic properties of drugs. The methyl group is relatively small and has a certain electron supply effect, which can affect the density and spatial structure of the molecular electron cloud, and change the acidity, alkalinity and reactivity of the molecule.
In addition, the pyridine ring of 6-fluoro-2-methylpyridine-3-boronic acid is aromatic and has good stability, and the pyridine nitrogen atom can provide lone pair electrons to coordinate with metal ions, or participate in nucleophilic and electrophilic reactions, further enriching its chemical reactivity. Under appropriate conditions, the pyridine ring can be modified, and other functional groups can be introduced to expand its application in organic synthesis. In conclusion, 6-fluoro-2-methylpyridine-3-boronic acid plays an important role in the field of organic synthesis due to its unique structure and diverse chemical properties.

The common synthesis methods of 6-fluoro-2-methylpyridine-3-boronic acid are as follows.
One is the halogenated pyridine method. First, 6-fluoro-2-methyl-3-halogenated pyridine is used as the starting material and reacts with organometallic reagents, such as n-butyllithium, at low temperature and under severe conditions without water and oxygen, to form a lithiated intermediate. Then, this intermediate interacts with borate esters, such as trimethoxyborate, and through a hydrolysis step, the target product 6-fluoro-2-methylpyridine-3-boronic acid can be obtained. Although the reaction conditions of this method are relatively harsh, the steps are relatively clear, and it is quite common in synthesis.
The second is the pyridyl borate method. Select a suitable pyridyl borate derivative, and introduce fluorine atoms and methyl groups through a specific substitution reaction. This requires precise selection of reaction reagents and conditions. Common reagents such as fluorine-containing reagents and methylating reagents, with the help of catalysts, realize the substitution process, and finally obtain 6-fluoro-2-methylpyridyl-3-boronic acid. This method requires high control of reaction conditions and selection of reagents, but it can provide a different synthesis path.
The third is the transition metal catalysis method. With the help of transition metal catalysts, such as palladium catalysts, suitable pyridine derivatives are coupled to boron sources. The suitable halogenated pyridine derivatives and boron reagents are used as raw materials, and the reaction is heated in a suitable solvent in the presence of palladium catalysts and ligands. In this process, the activity of the catalyst and the choice of ligands have a great influence on the reaction. Precise regulation can effectively improve the yield and purity of the product. It is also an important method for the synthesis of 6-fluoro-2-methylpyridine-3-boronic acid.

6-Fluoro-2-methylpyridine-3-boronic acid is an important chemical reagent in the field of organic synthesis. In the field of pharmaceutical research and development, its role is significant. It is often used as a key intermediate in the construction of many drug molecules. Due to its special structure, it can participate in many reactions and help synthesize compounds with specific biological activities, such as new drugs targeting certain disease targets.
In the field of materials science, it also has outstanding performance. It can be used to prepare functional materials, such as optoelectronic materials. By reacting with other substances, it can endow materials with unique optical or electrical properties, which can be used in the manufacture of organic Light Emitting Diodes (OLEDs) and other devices to improve the performance of devices.
In the field of agricultural chemistry, it also plays a certain role. It may participate in the synthesis of compounds with insecticidal, bactericidal or herbicidal activities, providing key raw materials for the development of new pesticides, helping to improve the yield and quality of crops, and ensuring the sustainable development of agriculture.
In terms of scientific research and exploration, as organoboron compounds, they provide an important tool for basic research in organic chemistry. By studying their reaction characteristics, scientists expand their understanding of organic reaction mechanisms, promote the progress of organic synthesis methodologies, and lay the foundation for the synthesis of more complex and innovative compounds.

The market price of 6-fluoro-2-methylpyridine-3-boronic acid varies according to market conditions, quality, quantity and supplier. Looking at the method of "Tiangong Kaiwu" in the past, although the price of this product is not directly stated, it can be learned from commercial reasons.
The price of commercial goods in the past depends on supply and demand. If there are many people who want this product, and there are few people who supply it, the price will be high; on the contrary, if the supply exceeds the demand, the price will decrease. And the difficulty of its preparation is also related to the price. If the preparation requires exquisite craftsmanship and rare materials, the cost will be high, and the price will follow. < Br >
Also, the quality is divided into price. High-quality products, few impurities, high purity, or several times the price. The amount is also key. Block trade, or due to the benefit of scale, the price of the unit can be reduced; small purchases, the price may be high.
Based on current market conditions, the price per gram may be between tens of yuan and hundreds of yuan. If the purchase quantity is small, such as only a few grams, or due to processing and packaging costs, the price per gram may be nearly 100 yuan, or even higher. However, if you buy in bulk, such as kilograms, with economies of scale, the price per gram may be reduced to tens of yuan.
It should be noted that different suppliers have different pricing. Well-known large factories have slightly higher prices due to good quality control and after-sales service; emerging small factories are competing for the market, and the prices may be cheaper. For accurate prices, it is advisable to consult suppliers and compare their quotations to obtain accurate figures.

6-Fluoro-2-methylpyridine-3-boronic acid is an important reagent commonly used in organic synthesis. Its storage conditions are crucial and related to the stability and quality of the substance.
This compound should be stored in a cool and dry place. In a cool environment, it can relieve the danger of accelerating chemical reactions due to excessive temperature. If it is exposed to high temperature, or the molecular activity is enhanced, it will cause adverse reactions such as decomposition and polymerization. It is indispensable for drying. Due to its boric acid group, it is easy to react with water, deliquescent and deteriorate, lose its inherent chemical properties, and reduce its effectiveness in synthetic reactions.
Furthermore, coexistence with oxidants should be avoided. Due to its chemical structure, it is prone to violent reactions when exposed to oxidants, or the risk of combustion or explosion. When storing, it should be stored separately and packed with suitable packaging materials. Containers made of glass or specific plastic materials are commonly used to ensure good sealing and prevent air and moisture from invading.
During the use process, caution is also required. The operating environment should be clean, dry, and well ventilated to prevent dust formation and reduce fire and health risks. Seal the container after use and return it to the original storage place to ensure its long-term and stable quality, and play its due role in subsequent organic synthesis experiments and production.