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What is the chemical structure of 6-ethoxypyridine-3-carboxylic acid?
6-Acetoxybenzo-3-carboxylic acid. The chemical structure of this compound is an important topic in organic chemistry. Its structure is based on a benzene ring, and the ring is connected to a specific functional group.
The benzene ring has six carbon atoms and is a hexagonal ring structure, which is the core structure of the compound and gives it unique chemical properties such as aromaticity.
On the benzene ring, the No. 6 position is connected with an acetoxy group. The structure of the acetoxy group is that the acetyl group ($CH_3CO - $) is connected to the oxygen atom and then to the benzene ring. In the acetyl group, the methyl group ($CH_3 - $) is connected to the carbonyl group ($C = O $), the carbon of the carbonyl group is electrophilic, and the oxygen atom has a certain electronegativity. This structure makes the acetoxy group affect the electron cloud distribution of the benzene ring, which in turn affects the reactivity of the compound. The position
3 is connected with a carboxyl group ($-COOH $). The carboxyl group is formed by connecting the carbonyl group to the hydroxyl group, and has some properties of the carbonyl group and the hydroxyl group. The oxygen-hydrogen bond in the hydroxyl group has a certain polarity, and the hydrogen atom can be dissociated, making the carboxyl group acidic and able to participate in acid-base reactions. At the same time, the carbon of the carbonyl group can also undergo
The overall structure of this compound exhibits unique physical and chemical properties due to the interaction of benzene ring, acetoxy group and carboxyl group. Its electron cloud interacts and conjugates between benzene ring and various functional groups, determining its stability and participating in various organic reactions. It is of great significance in many fields such as organic synthesis and medicinal chemistry.
What are the main uses of 6-ethoxypyridine-3-carboxylic acid?
6-Aminopyridine-3-carboxylic acid, also known as 6-aminonicotinic acid, is a class of organic compounds with a variety of important uses. Its main uses can be briefly described as follows:
In the field of medicine, 6-aminopyridine-3-carboxylic acid can be used as an intermediate in drug synthesis. Because of its unique chemical structure, it can participate in the construction of many drug molecules. For example, in the development of some drugs for specific diseases, such as cardiovascular diseases and neurological diseases, this compound can be used as a key starting material and converted into drug molecules with specific pharmacological activities through a series of chemical reactions. By modifying and modifying its structure, drugs with different curative effects and characteristics can be obtained, making great contributions to human health.
In the field of materials science, 6-aminopyridine-3-carboxylic acid also shows unique value. It can be used to prepare functional materials, such as some polymer materials with special optical and electrical properties. In the polymerization reaction, the compound can participate as a monomer or crosslinking agent, giving the material special physical and chemical properties. For example, the preparation of materials with fluorescent properties has potential applications in sensors, biological imaging and other fields; or the preparation of materials with good electrical conductivity for electronic devices.
In agriculture, 6-aminopyridine-3-carboxylic acid can be used as an intermediate for the synthesis of pesticides. With its chemical properties, pesticide products with high insecticidal, bactericidal or herbicidal properties can be synthesized. Compared with traditional pesticides, pesticides synthesized based on this compound may have lower toxicity, higher selectivity and better environmental compatibility, which is conducive to the sustainable development of agriculture, ensuring crop yield and quality while reducing the negative impact on the environment.
In addition, in the field of organic synthetic chemistry, 6-aminopyridine-3-carboxylic acid is an important synthetic building block, which is widely used in the construction of various complex organic molecules. Chemists use its active reaction check point and ingenious reaction design to synthesize a series of organic compounds with novel structures and unique functions, providing a rich material basis and research ideas for the development of organic synthetic chemistry.
What are the synthesis methods of 6-ethoxypyridine-3-carboxylic acid?
There are many methods for synthesizing 6-acetoxyacetophenone-3-carboxylic acid, each with its own advantages. The following is a detailed description of Jun.
First, acetophenone is used as the starting material, and the acetoxy group is introduced through the Fu-gram acylation reaction, and then the carboxyl group is introduced at a specific position in the benzene ring under specific conditions. The raw materials of this method are easy to obtain, but there are many reaction steps. The reaction conditions need to be precisely controlled to ensure the selectivity of each step of the reaction, otherwise it is easy to produce side reactions and reduce the purity of the product.
Second, the acetoxyphenol can be obtained by esterification from the corresponding phenolic compound, and then the acetyl group and carboxyl group are introduced through a series of steps such as halogenation and Grignard reaction. The route of this method is exquisitely designed and can better control the position of the substituent. However, some reaction conditions are harsh and the equipment requirements are quite high, and the reagents used may have certain toxicity. It is necessary to operate carefully, and take protective measures and treat the three wastes.
Third, the carbon-carbon bond is constructed by the coupling reaction catalyzed by palladium. The aromatic derivatives containing acetoxy groups and suitable leaving groups are used as substrates, and the nucleophiles containing carboxyl groups are coupled under the action of palladium catalysts. This method has relatively mild reaction conditions and high selectivity, which can efficiently synthesize the target product. However, the price of palladium catalysts is expensive, which increases production costs, and the separation and recovery of catalysts after the reaction is difficult, which limits its large-scale application to a certain extent.
Fourth, biosynthesis is used. Using specific microorganisms or enzymes to catalyze the conversion of specific substrates to 6-acetoxyacetophenone-3-carboxylic acid. This method is green and environmentally friendly, the reaction conditions are mild, and the selectivity is extremely high. However, the biological system is complex, the cost of cultivating microorganisms or preparing enzymes is high, and the reaction scale is limited. Large-scale industrial production still faces many challenges.
What are the physical properties of 6-ethoxypyridine-3-carboxylic acid?
6-Ethoxybenzoyl-3-pyridinic acid is an organic compound with specific physical properties. It is usually white to light yellow crystalline powder, and this appearance characteristic is easy to visually identify.
In terms of melting point, it is in a specific temperature range, because the exact value varies with purity and test conditions. Generally, at a certain temperature, the substance changes from solid to liquid. This melting point information is of great significance for its identification and purity judgment. In the chemical and pharmaceutical fields, it can be used as a key indicator for quality control.
In terms of solubility, it is slightly soluble in water. This is because the molecular structure contains a hydrophobic part, which affects the dispersion in water. However, it is soluble in some organic solvents, such as ethanol, dichloromethane, etc. This solubility provides a basis for the selection of suitable solvents in the synthesis and extraction process, which is conducive to related operations.
In addition, 6-ethoxybenzoyl-3-pyridyl acid is relatively stable chemically at room temperature and pressure, but under specific conditions, such as high temperature, strong acid and alkali environment, chemical reactions may occur. Understanding these physical properties is of great significance for its storage, transportation and use. When storing, appropriate conditions need to be selected according to its properties to ensure the quality and stability of the material, which is indispensable for industrial production and scientific research applications.
What is the price range of 6-ethoxypyridine-3-carboxylic acid in the market?
The price of 6-ethoxypyridine-3-carboxylic acid in the market depends on the change of quality and supply and demand. Looking at the state of the market, if the quality is excellent, the price may be slightly higher; if the quality is average, the price is also equal.
At present, the price of 6-ethoxypyridine-3-carboxylic acid in the market is about [X1] yuan to [X2] yuan per gram. If you buy it in batches, the greater the quantity, the better the price. The approximate amount exceeds 100 grams, and the price per gram may drop to about [X3] yuan.
However, this price is not constant. The supply and demand of the market may change from time to time. If the supply exceeds the demand, the merchant will sell the goods quickly, and the price may decline; if the demand exceeds the supply, the goods are thin and the demand is large, the price will rise. And the raw material price, labor cost, transportation cost, etc. of this product can make the price of 6-ethoxypyridine-3-carboxylic acid easy. If the price of raw materials increases, the labor cost and transportation cost increase, the price will also increase; otherwise, the price may decrease.
To know the exact price, it is essential to consult the chemical raw material suppliers or visit the chemical product trading platform to obtain real-time price information.