6-Cyanopyridine-3-carboxylic acid

6-Cyanopyridine-3-carboxylic acid is also a chemical substance. Its use is very important, and it has outstanding efficacy in the way of synthesis.
In the field of material science, it also has its own application. It may be able to improve the performance of special materials, such as mechanical quality and qualitative quality, so that it can be used in many special situations.
In addition, in the field of research and development, it also has an indispensable role. It can be used as a raw material for high-efficiency and low-toxicity synthesis, protecting crops from disease invasion, protecting food harvest, and laying the foundation for people's livelihood.
Therefore, 6-cyanopyridine-3-carboxylic acid, with its diverse characteristics, plays an important role in manufacturing, materials, and manufacturing, promoting the development of all walks of life and benefiting the world.

6-Cyanopyridine-3-carboxylic acid is an organic compound. Its physical properties are as follows:
From the perspective of this substance, it usually shows a white to quasi-white solid state. This color state characteristic is common in many organic compounds and can provide a preliminary basis for identifying the substance.
When it comes to the melting point, its value is about 220-224 ° C. As an important physical constant of a substance, the melting point is of great significance for the determination of the purity and thermal stability of the compound. Under specific experimental conditions, the purity of the compound can be determined by accurately measuring the melting point. If impurities are mixed, the melting point is often shifted.
Furthermore, the solubility of the substance in water is quite low. This solubility characteristic is related to the cyanyl and carboxyl groups in its molecular structure. The cyanyl group is a strong electron-absorbing group. Although the carboxyl group has a certain hydrophilicity, the hydrophobicity of the whole molecule dominates, making it difficult to dissolve in water. However, in polar organic solvents such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF), it exhibits relatively good solubility. This property has far-reaching implications in the field of organic synthesis and drug development. Scientists can choose suitable reaction solvents according to this to promote the smooth progress of related chemical reactions.
In addition, 6-cyanopyridine-3-carboxylic acid is chemically stable at room temperature and pressure. However, it should be noted that it is more sensitive to humidity and may undergo certain chemical changes after being exposed to moisture. Therefore, during storage and use, attention should be paid to moisture-proof measures to ensure that the quality and performance of the substance are not affected.

The synthesis of 6-cyanopyridine-3-carboxylic acid has been investigated by many scholars in the past, but now it is Jun Chen's.
One method is to use 6-aminopyridine-3-carboxylic acid as the starting material. First, it reacts with sodium nitrite and acid at low temperature to form a diazonium salt. This diazonium salt is very active, and then the cyanide solution of cuprous cyanide is added, and the diazonium group is then replaced by the cyanide group to obtain 6-cyanopyridine-3-carboxylic acid. In this process, the control of low temperature and the ratio of reagents need to be carefully controlled. If there is a slight difference, the yield will be affected. < Br >
Another method is to use a suitable pyridine derivative as the starting material. First, a halogen atom is introduced at a specific position on the pyridine ring. Subsequently, under the action of cyanide reagents such as potassium cyanide or sodium cyanide, in the presence of suitable solvents and catalysts, the halogen atom undergoes a nucleophilic substitution reaction with the cyanyl group. The selected solvent needs to be able to dissolve the reactants without reacting violently with the reagents; the choice of catalyst is also related to the reaction rate and yield. After this reaction, the target product 6-cyanopyridine-3-carboxylic acid can be obtained.
Furthermore, pyridine-3,6-dicarboxylic acid can be used. First, one of its carboxyl groups is converted into a leaving group, such as acyl chloride. Then the derivative is reacted with a cyanide reagent, and the cyano group replaces the leaving group. After appropriate treatment, the other carboxyl group is retained, and finally 6-cyanopyridine-3-carboxylic acid can be obtained. In this process, the conditions of each step of the reaction, such as temperature, reaction time, and reagent dosage, are all critical, and careful regulation is required to make the reaction smooth and obtain a higher yield product.

The price range of 6-cyanopyridine-3-carboxylic acid in the market is difficult to determine. Due to the ever-changing market conditions, its price is affected by various factors.
First, the price of raw materials is the main factor. If the price of the starting material required for the synthesis of this acid fluctuates according to the origin, season, and supply and demand, the price of 6-cyanopyridine-3-carboxylic acid will also fluctuate. If the origin of the raw material is in a disaster, the output will drop sharply, and the price will rise, and the price of this acid will also rise.
Second, the preparation process is also affected. If a method can produce efficiently, with low energy consumption and low impurities, the cost will decrease and the price may be low. However, if the process is complicated, high-end equipment and multiple processes are required, the cost will increase and the price will be high.
Furthermore, the market supply and demand situation is the key. If many industries have strong demand for it, such as pharmaceuticals, materials science and other fields, and the supply is limited, the price will rise. On the contrary, if the demand is weak and the supply is abundant, the price will decrease.
Repeat, the scale of production is also related. Large-scale production, due to the scale effect, the unit cost may decrease, and the price may also be close to the people; small-scale production, the unit cost is high, and the price may not be low.
And different merchants have different pricing due to their business strategies, cost control, and brand reputation. Therefore, in order to know the exact price range, it is necessary to carefully observe the dynamics of the chemical market and consult suppliers to obtain a more accurate number. Or hovering in the range of tens to hundreds of yuan per kilogram, which is only speculation, and the truth depends on market conditions.

6-Cyanopyridine-3-carboxylic acid, this material is delicate, and it needs to be stored with caution. It should be placed in a cool and dry place, away from the heat and humidity. Due to high temperature, its properties can be changed, and moisture can also cause qualitative changes and damage its purity.
And avoid it from encountering fire sources and strong oxidants. Fire sources can cause it to explode, and strong oxidants may come into contact with it, which may cause violent reactions and endanger safety. The preservation device should be selected as a sealed bottle. The glass material is preferably made of glass, which can block the intrusion of external moisture and air.
When using it, handle it with care, and strictly abide by the operating procedures. Do not let it spill and leak. This is the essence of preserving 6-cyanopyridine-3-carboxylic acid, and it must not be neglected in order to ensure its quality as before for future use.