6 Chloro 5 Trifluoromethyl 3 Pyridinemethanol
pyridine pyrrole pyrazine piperidine piperazine

6-chloro-5-(trifluoromethyl)-3-Pyridinemethanol

    Specifications

    HS Code

    589836

    Chemical Formula C7H5ClF3NO
    Molecular Weight 211.57
    Appearance Solid (Typical)

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    General Information
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    Frequently Asked Questions

    As a leading 6-chloro-5-(trifluoromethyl)-3-Pyridinemethanol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of 6-chloro-5- (trifluoromethyl) -3-Pyridinemethanol
    6-Chloro-5- (trifluoromethyl) -3-pyridyl methanol, this is one of the organic compounds. Looking at its structure, the pyridine ring is its core skeleton, the chlorine atom and the trifluoromethyl are respectively connected to the specific position of the pyridine ring, and the methanol group is also connected to the pyridine ring.
    Its chemical properties are unique. Because the pyridine ring is aromatic, this compound has certain stability. The chlorine atom is highly active and can participate in a variety of nucleophilic substitution reactions. For example, when reacting with nucleophiles such as sodium alcohol and amines, the chlorine atom can be replaced by the corresponding group to form a series of derivatives, which is an important way to construct new pyridine compounds.
    Trifluoromethyl is a strong electron-absorbing group. Due to its existence, the electron cloud density of the pyridine ring decreases, which increases the difficulty of electrophilic substitution reaction on the ring. However, under specific conditions, electrophilic substitution can also occur, and the reaction check point is mostly affected by the positioning effect of trifluoromethyl and chlorine atoms.
    Methanol groups can undergo a variety of reactions. Under the action of appropriate oxidants, they can be oxidized to aldehyde groups or carboxyl groups. In case of dehydrating agents, intramolecular or intermolecular dehydration reactions can also occur to form ether or olefin compounds.
    In addition, this compound has a wide range of uses in the field of organic synthesis. Due to its unique structure, it is often used as a key intermediate to synthesize important compounds in many fields such as medicine, pesticides and functional materials. In pharmaceutical research and development, its structure may be modified to obtain molecules with specific biological activities, which are expected to become potential drugs for treating specific diseases.
    What are the preparation methods of 6-chloro-5- (trifluoromethyl) -3-Pyridinemethanol
    There are many methods for preparing 6-chloro-5- (trifluoromethyl) -3-pyridyl methanol. According to the ancient books, there are three methods.
    First, 6-chloro-5- (trifluoromethyl) -3-pyridyl carboxylate is used as the starting material. In an alcohol solvent, such as methanol or ethanol, add an appropriate amount of strong reducing agent, such as sodium borohydride or lithium aluminum hydride. Mix the two, heat them slowly, and maintain a certain temperature, about 40 to 60 degrees Celsius, during which a reduction reaction occurs. In this process, the formate group is reduced to methanol group. After several hours or even tens of hours of reaction, when the reaction is complete, pure 6-chloro-5- (trifluoromethyl) -3-pyridyl methanol can be obtained by conventional separation methods, such as extraction, distillation, recrystallization, etc.
    Second, 6-chloro-5- (trifluoromethyl) -3-pyridyl formaldehyde is used as raw material. In a suitable reaction vessel, add an appropriate amount of formaldehyde and an alkaline catalyst, such as a dilute solution of sodium hydroxide or potassium hydroxide. Control the reaction temperature at 20 to 30 degrees Celsius, this is the beginning of the hydroxyaldehyde condensation reaction. Then, the reaction product is reduced by a suitable reducing agent, such as the Clemmensen reduction system composed of zinc amalgam and concentrated hydrochloric acid, which can convert the aldehyde group into methanol group. After the reaction is completed, the target product can also be obtained after separation and purification.
    Third, 6-chloro-5- (trifluoromethyl) -3-halopyridine is used as the starting material. In an organic solvent, such as N, N-dimethylformamide, an appropriate amount of metallic magnesium is added to prepare a Grignard reagent. Then, slowly add the ether solution of formaldehyde dropwise and react at low temperature, about -10 to 0 degrees Celsius. After the reaction is complete, hydrolyze with dilute acid to convert the Grignard reagent intermediate into 6-chloro-5- (trifluoromethyl) -3-pyridyl methanol. Subsequent steps such as extraction, drying, distillation, etc., the final pure product is obtained.
    These three preparation methods have their own advantages and disadvantages, and they need to be followed according to the actual situation, such as the availability of raw materials, cost considerations, and product purity requirements.
    In which fields is 6-chloro-5- (trifluoromethyl) -3-Pyridinemethanol used?
    6-Chloro-5- (trifluoromethyl) -3-pyridyl methanol is useful in many fields.
    In the field of pharmaceutical research and development, it has great potential value. Because pyridyl methanol compounds often have unique biological activities, or can be used as lead compounds, it helps medical scientists to explore new drug molecules. Through the study of its structure modification and activity, it is expected to develop innovative drugs for specific diseases, such as antibacterial and antiviral drugs, to help human health and well-being.
    In the field of organic synthesis, it is an important intermediate. With the characteristics of its own chlorine atom, trifluoromethyl group and methanol group, it can participate in a variety of chemical reactions, such as nucleophilic substitution, esterification, oxidation, etc. Chemists use this to construct complex organic molecular structures, laying the foundation for the synthesis of functional materials, total synthesis of natural products, etc., and expanding the boundaries of organic synthesis.
    In the field of materials science, it may also have applications. Compounds containing trifluoromethyl group often have unique physical and chemical properties, such as good thermal stability, chemical stability and low surface energy. 6-Chloro-5- (trifluoromethyl) -3-pyridyl methanol may be introduced into the material structure through specific reactions to improve material properties, such as the preparation of high-performance polymer materials, used in aerospace, electronic devices and other fields that require strict material properties.
    This compound has shown broad application prospects in the fields of medicine, organic synthesis, materials science, etc. With the deepening of scientific research, its potential value may be further explored and utilized.
    What is the market outlook for 6-chloro-5- (trifluoromethyl) -3-Pyridinemethanol?
    6-Chloro-5- (trifluoromethyl) -3-pyridyl methanol, this substance is often a key intermediate in the creation of new specific drugs in the field of medicine and chemical industry. Looking at today's market, its prospects are shining, and the demand is on the rise.
    From the perspective of pharmaceutical research and development, with the unremitting exploration of difficult diseases, the research and development process of innovative drugs with this structure has accelerated. Many scientific research teams focus on its unique chemical properties, hoping to use it to construct high-efficiency, low-toxicity, and highly specific drug molecules. This is because its chlorine atom and specific groups such as trifluoromethyl can significantly adjust the physicochemical properties and biological activities of drugs, and help to accurately combine drugs with targets. Therefore, pharmaceutical companies are increasingly demanding it, and strive to ensure the supply of raw materials for R & D and production.
    From the perspective of the chemical industry, it has a wide range of uses in the field of fine chemicals. It can not only be used as an important raw material for the synthesis of special functional materials, but also has great potential in the creation of new pesticides. With the concept of green environmental protection deeply rooted in the hearts of the people, the research and development of high-efficiency, low-toxicity and environmentally friendly pesticides has become a trend. 6-chloro-5- (trifluoromethyl) -3-pyridyl methanol is in line with this development demand due to its structural advantages. Chemical companies have increased their attention and use of it.
    However, there are also challenges in the market. First, the synthesis process is complex and the cost remains high, limiting large-scale application; second, the environmental protection requirements are becoming stricter, and the production process needs to strictly follow standards, increasing production costs and technical difficulties. But overall, with technological progress and process optimization, 6-chloro-5- (trifluoromethyl) -3-pyridyl methanol, with its excellent performance, still has broad prospects in the pharmaceutical and chemical markets, and will play an increasingly critical role in promoting the innovation and development of related industries.
    What are the storage conditions for 6-chloro-5- (trifluoromethyl) -3-Pyridinemethanol?
    6-Chloro-5- (trifluoromethyl) -3-pyridyl methanol is an important organic compound in the field of fine chemicals. Its storage conditions need to be treated with caution to ensure the quality and stability of this substance.
    The first to bear the brunt is to store it in a cool place. Because the temperature is too high, it is very easy to trigger chemical reactions of the compound, causing it to deteriorate. Imagine that under the hot sun, everything is easily changed by baking, and this compound is no exception. High temperature may change its molecular structure, which in turn affects its chemical properties. Therefore, choosing a cool place can effectively slow down the rate of reaction that may occur.
    Secondly, a dry environment is indispensable. Water is the medium for many chemical reactions. If the environment is humid, moisture can easily interact with the compound. Or initiate a hydrolysis reaction and destroy its original structure. Like water drops through rocks, although water seems weak, it can change the form of matter under long-term action. For this compound, the humid environment may also gradually erode its chemical structure, reducing its purity.
    Furthermore, it should be placed in a well-ventilated place. If the storage space is poorly ventilated, the volatile gas of the compound may accumulate. Once a certain concentration is reached, it may not only affect the properties of the compound itself, but also pose a safety hazard, such as an open flame, or cause danger. Good ventilation can disperse volatile gas in time and maintain the safety of the storage environment.
    In addition, it needs to be stored separately from oxidizing agents, acids, bases and other substances. The chemical properties of this compound determine that it is easy to react with these substances. Oxidizing agents have strong oxidizing properties, or capture electrons in the compound and change its chemical composition; acids and bases may react with acids and bases to destroy their molecular structure. Just like people of different personalities, if they don't get along well, they are prone to conflict. The same is true for these chemicals. < Br >
    Store 6-chloro-5- (trifluoromethyl) -3-pyridyl methanol in a cool, dry, well-ventilated place, and avoid contact with incompatible substances, so as to ensure its quality and stability during storage, for subsequent production, research and other needs.