6-Chloro-5-methylpyridine-3-boronic acid

6-Chloro-5-methylpyridine-3-boronic acid, this is an organic compound. Its molecules contain chlorine atoms, methyl groups, pyridine rings and boric acid groups, and have a unique structure.
From the perspective of physical properties, it is mostly white to white solid. Stable at room temperature and pressure, but sensitive to humidity, easy to absorb moisture, and need to pay attention to moisture when storing.
In terms of chemical properties, boric acid groups are active and can participate in many reactions. First, they can be esterified with alcohols, and under appropriate catalyst and reaction conditions, borate esters are formed. This reaction is often used in organic synthesis to protect hydroxyl groups or to construct specific structural compounds. Second, Suzuki-Miyaura coupling reaction can be carried out to form carbon-carbon bonds with halogenated aromatics or halogenated olefins in the presence of palladium catalysts and bases, which is of great significance in the construction of complex organic molecules, drug synthesis and materials science. Third, due to the weak acidity of boric acid groups, they can neutralize with bases to generate corresponding borates. This property may be used in adjusting the pH of the reaction system and the separation and purification of products.
Furthermore, the chlorine atoms in the molecule also have certain reactivity, and can be replaced by nucleophiles under specific conditions to achieve functional group transformation, enrich the structure and properties of compounds, and provide various possibilities for organic synthesis.

6-Chloro-5-methylpyridine-3-boronic acid has a wide range of uses. It is often a key intermediate in the field of organic synthesis. First, when building the structure of complex pyridine compounds, with its boric acid group characteristics, it can be coupled with many halides to efficiently generate carbon-carbon bonds or carbon-heteroatomic bonds, which can help to synthesize pyridine derivatives with diverse structures. Such derivatives are of great significance in the field of medicinal chemistry. In the research and development of many new drugs, pyridine-like structural compounds often exhibit unique biological activities, or have antibacterial, anti-inflammatory, and anti-tumor effects. 6-chloro-5-methylpyridine-3-boronic acid is the cornerstone for the synthesis of such potentially active drug molecules.
Furthermore, in the field of materials science, materials with specific photoelectric properties can be prepared through the chemical reactions they participate in. By rationally designing the reaction path and introducing it into polymers or other material systems, the electronic transport and luminescence properties of materials can be regulated, providing new opportunities for the development of organic optoelectronic materials. For example, it is expected to be applied to devices such as Light Organic Emitting Diode (OLED) and solar cells to improve their performance and efficiency.
In addition, in chemical biology research, probe molecules synthesized from this substance, or due to the synergistic effect of pyridine structure and boric acid groups, exhibit high selectivity in recognizing specific biomolecules, which is conducive to in-depth exploration of complex physiological processes and molecular mechanisms in vivo, and provides new strategies and methods for disease diagnosis and treatment.

The synthesis method of 6-chloro-5-methylpyridine-3-boronic acid has been known in ancient times, and is described in detail today.
First, halogenated pyridine is used as the starting material. Choose the appropriate halogenated pyridine, such as 6-chloro-5-methylpyridine-3-halide, and react carefully with organometallic reagents, such as alkyl lithium reagents, in a suitable organic solvent, such as anhydrous tetrahydrofuran, in a low temperature environment. This step requires strict temperature control to ensure a smooth reaction. The resulting lithiated intermediate is added to the reaction system in a timely manner with borate esters, such as trimethoxy borate, and after hydrolysis treatment, 6-chloro-5-methylpyridine-3-boronic acid can be obtained.
Second, by the method of catalytic coupling of transition metals. The reaction is heated with 6-chloro-5-methylpyridine-3-halide and boron sources, such as pinacol borane, with the assistance of transition metal catalysts, such as palladium catalysts, and ligands, in a suitable solvent, such as toluene. During this process, the ratio of catalyst to ligand, the reaction temperature and time must be precisely controlled. After the reaction is completed, the target product can also be obtained through the steps of separation and purification.
Third, pyridine derivatives are used as substrates and converted in multiple steps. First, specific substitution reactions are carried out on pyridine derivatives, suitable substituents are introduced, and then a series of reactions such as oxidation and boronation are carried out to gradually construct the target molecular structure. Each step of the reaction needs to select suitable reaction conditions and reagents according to the reaction mechanism, so as to achieve the purpose of efficient synthesis.
Synthesis of 6-chloro-5-methylpyridine-3-boronic acid requires a variety of methods, depending on factors such as raw material availability, ease of control of reaction conditions and cost.

For 6-chloro-5-methylpyridine-3-boronic acid, many matters need to be paid more attention during storage and transportation. The nature of this compound may be unstable, so the first storage environment. Choose a cool, dry and well-ventilated place, away from direct sunlight, due to the heat and radiation of sunlight, or cause it to deteriorate. Humidity is also critical, and a high-humidity environment may cause it to deliquescence, which will damage the quality.
The choice of storage container should not be underestimated. It is advisable to use a container with good sealing performance to prevent contact with air. Due to the oxygen and water vapor in the air, it can chemically react with it. If it is stored in a glass container, it is necessary to check whether it is damaged, and the plastic container should consider whether the material is compatible with it to prevent interaction.
When transporting, be sure to ensure that the packaging is stable. This item may be dangerous. If the packaging is not solid, it will be bumpy and collided during transportation, which will easily cause leakage and endanger the safety of transporters and the environment. And the means of transportation must also be kept dry and cool. Temperature control devices may be necessary, especially for long-distance transportation. If the temperature fluctuates too much or causes it to decompose, etc.
Furthermore, people who operate and come into contact with this item need to take protective measures. If you wear appropriate protective gloves, goggles, and protective clothing, it will endanger your health due to direct contact or irritation of the skin, eyes, inhalation or ingestion. During storage and transportation, all relevant safety procedures and operating guidelines should be strictly followed, and no negligence should be allowed to ensure personnel safety and material quality.

6-Chloro-5-methylpyridine-3-boronic acid, its market price range is often changed due to a variety of factors. Looking at the state of the chemical market in the past, the price of this compound is affected by various factors such as the difficulty of obtaining raw materials, the complexity of the synthesis process, and the amount of market demand.
If the raw materials are abundant and easy to obtain, the synthesis method is simple and exquisite, and the market demand does not show a drastic change, the price may stabilize. However, the raw materials are scarce, it is difficult to find, and the synthesis process is complicated, requiring exquisite methods and high costs, or the market demand surges, and the supply exceeds the demand, the price will rise.
Based on past market conditions, the price of this product may fluctuate between tens of yuan and hundreds of yuan per gram. When demand is low and supply is sufficient, its price may fall to tens of yuan per gram; and when demand is strong, supply is tight, and the process is difficult, its price can reach hundreds of yuan per gram.
However, the chemical market is changing, like waves in the ocean, and prices are often changing rapidly due to current situations, policies, emergencies, etc. Therefore, in order to know its accurate market price, it is necessary to constantly check the news of the chemical trading platform and consult the merchants in the industry to obtain the current realistic price range, so as not to delay business.